gene

WDR45

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WDR45: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

256Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

WDR45 is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, activates. Associated with Als, Amyotrophic Lateral Sclerosis, BPAN. Connected to 126 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WDR45
Full Name	WD Repeat Domain 45
Aliases	Page for WDR45, WIPR1
Chromosome	Xp11.23<br/>
Function	WDR45 (also called WIPR1) participates in autophagy
Primary Expression	neuronal tissues:
Molecular Weight	39 kDa
Pathways	mTOR, mtor
UniProt ID	Q9Y5X9
NCBI Gene ID	11152
Ensembl ID	ENSG00000196998
GeneCards	WDR45
Human Protein Atlas	WDR45
Associated Diseases	ALS, Amyotrophic Lateral Sclerosis, BPAN, Cancer, Cardiovascular
Known Drugs/Compounds	rapamycin
Interactions	G3BP1, ATG2A, PIK3C3, ESR2, HDAC6, SOX9
KG Connections	256 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: WDR45 — AlphaFold Q9Y5X9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    WDR45["WDR45"]
    WDR45 -->|"binds"| Caprin_1["Caprin-1"]
    WDR45 -->|"participates in"| autophagy["autophagy"]
    WDR45 -->|"causes"| ER_stress["ER stress"]
    WDR45 -->|"causes"| neuronal_apoptosis["neuronal apoptosis"]
    WDR45 -->|"causes"| neurodegeneration["neurodegeneration"]
    WDR45 -->|"causes"| brain_iron_accumulation["brain iron accumulation"]
    WDR45 -->|"causes"| intellectual_disability["intellectual disability"]
    WDR45 -->|"encodes"| WIPI4["WIPI4"]
    WDR45 -->|"regulates"| Cancer["Cancer"]
    WDR45 -->|"regulates"| Cardiovascular["Cardiovascular"]
    biotin["biotin"] -->|"upregulates"| WDR45
    MTOR["MTOR"] -->|"regulates"| WDR45
    ATG["ATG"] -->|"regulates"| WDR45

Outgoing (131)

Target	Relation	Type	Str
BPAN	causes	disease	0.95
Caprin-1	binds	protein	0.90
Macroautophagy	regulates	process	0.90
ER Homeostasis	regulates	process	0.85
ER stress	causes	biological_process	0.80
neuronal apoptosis	causes	biological_process	0.80
neurodegeneration	causes	disease	0.80
brain iron accumulation	causes	phenotype	0.80
intellectual disability	causes	disease	0.80
Neurodegeneration	associated_with	disease	0.75
WIPI4	encodes	protein	0.70
BPAN	associated_with	disease	0.70
oxidative stress response	participates_in	pathway	0.70
Cancer	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Dystonia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	implicated_in	disease	0.65
Neurodegeneration	causes	disease	0.65
BECN1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
APP	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
VDAC2	associated_with	gene	0.60
ESR2	associated_with	gene	0.60
AMBRA1	associated_with	gene	0.60
COASY	associated_with	gene	0.60
DCAF17	associated_with	gene	0.60
FA2H	associated_with	gene	0.60
C19ORF12	associated_with	gene	0.60
PANK2	associated_with	gene	0.60
PLA2G6	associated_with	gene	0.60
G3BP1	activates	gene	0.60
SOX9	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
FYCO1	associated_with	gene	0.60

Incoming (125)

Source	Relation	Type	Str
biotin	upregulates	chemical	0.80
NEURODEGENERATION	associated_with	gene	0.70
ULK1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
FYCO1	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
SOX9	associated_with	gene	0.60
FTL	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
AMBRA1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
VDAC2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
ESR2	associated_with	gene	0.60
APP	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
WIPI4	associated_with	gene	0.60
SQSTM1	implicated_in	gene	0.60
P62	implicated_in	gene	0.60
UBIQUITIN	implicated_in	gene	0.60
WIPI4	regulates	gene	0.60
ATG2A	causes	gene	0.60
WIPI4	causes	gene	0.60
AMBRA1	activates	entity	0.60
APP	activates	entity	0.60
BCL2L1	activates	entity	0.60
BECN1	activates	entity	0.60
CTSD	activates	entity	0.60
ESR1	activates	entity	0.60
ESR2	activates	entity	0.60
FYCO1	activates	entity	0.60
GABARAP	activates	entity	0.60
GLA	activates	entity	0.60
HDAC6	activates	entity	0.60
LAMP2	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MTOR	activates	entity	0.60
PIK3C3	activates	entity	0.60
PSEN1	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

WDR45

Understanding Entity Pages

Summary

Wiki Pages (21)

WDR45 - WD Repeat Domain 45

Neuroferritinopathy

PKAN Mechanistic Pathway

AAV Gene Therapy Vectors for Neurodegeneration

C19orf12 Gene - Chromosome 19 Open Reading Frame 12

Pantothenate Kinase-Associated Neurodegeneration (PKAN)

Globus Pallidus

Disease Classification & Relationships

Protein Phase Separation in Neurodegeneration

Globus Pallidus Pkan

Pantothenate Kinase-Associated Neurodegeneration (PKAN)

SEC22B Gene

Beta-Propeller Protein-Associated Neurodegeneration (BPAN)

Metal Homeostasis in Neurodegeneration

Neurodegeneration with Brain Iron Accumulation (NBIA)

IREB2 — Iron Responsive Element Binding Protein 2

Dystonia

WIPI2 Protein

aceruloplasminemia