gene

CACNA1D

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA1D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections
0Hypotheses
0Analyses
18Outgoing
18Incoming
0Experiments

Summary

Page for CACNA1D Gene

View on Wiki →

🧬 Gene Info
Gene SymbolCACNA1D
Chromosome3p21.1
Protein FamilyVoltage-gated calcium channel (Cav1) family
FunctionCACNA1D encodes the α1D subunit of voltage-dependent L-type calcium channels, also known as Cav1.3
Primary Expressionneurons, cardiac pacemaker cells, and endocrine cells
Subcellular LocalizationCell membrane, dendritic shafts, presynaptic terminals
Molecular Weight245 kDa
UniProt ID[Q01658](https://www.uniprot.org/uniprot/Q01658)
GeneCardsCACNA1D
Human Protein AtlasCACNA1D
α1 Subunit (CACNA1D)Forms the transmembrane pore
β SubunitAuxiliary subunit affecting trafficking and kinetics
α2δ SubunitAuxiliary subunit increasing surface expression
γ SubunitModulatory subunit (in some tissues)
Low-Voltage ActivationActivates at potentials as negative as -50 mV (vs. -30 mV for Cav1.2)
Associated Diseasesneurodegeneration
InteractionsCACNA2D2, CACNA1I, CACNA2D1, CACNA1E, CACNA1H, CACNA1G
KG Connections36 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CACNA1D Gene

gene · 1070 words

Ion Channel Dysfunction in Huntington's Disease

mechanism · 3782 words

Calcium Signaling Dysregulation in Neurodegeneration

mechanism · 3676 words

Ion Channel Dysfunction in Parkinson's Disease

mechanism · 3382 words

Ion Channel Dysfunction in Alzheimer's Disease

mechanism · 3308 words

ion-channel-dysfunction-disease-comparison

mechanism · 3208 words

Pathway Diagram

graph TD
    CACNA1D["<b>CACNA1D</b>"]
    CACNA1G["CACNA1G"]
    CACNA1D -->|"associated with"| CACNA1G
    CCS["CCS"]
    CACNA1D -->|"contributes to"| CCS
    CACNA2D2["CACNA2D2"]
    CACNA1D -->|"associated with"| CACNA2D2
    CACNA1C["CACNA1C"]
    CACNA1D -->|"associated with"| CACNA1C
    CACNA1I["CACNA1I"]
    CACNA1D -->|"associated with"| CACNA1I
    CACNA1A["CACNA1A"]
    CACNA1A -->|"associated with"| CACNA1D
    CCS["CCS"]
    CCS -->|"contributes to"| CACNA1D
    CACNA1C["CACNA1C"]
    CACNA1C -->|"associated with"| CACNA1D
    CACNA2D2["CACNA2D2"]
    CACNA2D2 -->|"associated with"| CACNA1D
    CACNA1F["CACNA1F"]
    CACNA1F -->|"associated with"| CACNA1D
    CACNA1I["CACNA1I"]
    CACNA1I -->|"associated with"| CACNA1D
    CACNA2D1["CACNA2D1"]
    CACNA2D1 -->|"associated with"| CACNA1D
    CACNA1E["CACNA1E"]
    CACNA1E -->|"associated with"| CACNA1D
    CACNA1H["CACNA1H"]
    CACNA1H -->|"associated with"| CACNA1D
    GENES["GENES"]
    GENES -->|"associated with"| CACNA1D
    CACNA1G["CACNA1G"]
    CACNA1G -->|"associated with"| CACNA1D
    GAIN["GAIN"]
    GAIN -->|"contributes to"| CACNA1D
    AND["AND"]
    AND -->|"associated with"| CACNA1D
    CACNA2D2["CACNA2D2"]
    CACNA1D -->|"interacts with"| CACNA2D2
    CACNA1I["CACNA1I"]
    CACNA1D -->|"interacts with"| CACNA1I
    CACNA2D1["CACNA2D1"]
    CACNA1D -->|"interacts with"| CACNA2D1
    CACNA1E["CACNA1E"]
    CACNA1D -->|"interacts with"| CACNA1E
    CACNA1H["CACNA1H"]
    CACNA1D -->|"interacts with"| CACNA1H
    CACNA1G["CACNA1G"]
    CACNA1D -->|"interacts with"| CACNA1G
    CACNA1A["CACNA1A"]
    CACNA1D -->|"interacts with"| CACNA1A
    CACNA1C["CACNA1C"]
    CACNA1D -->|"interacts with"| CACNA1C
    Genes["Genes"]
    CACNA1D -->|"interacts with"| Genes
    cacna1f["cacna1f"]
    cacna1f -->|"interacts with"| CACNA1D
    neurodegeneration["neurodegeneration"]
    CACNA1D -->|"implicated in"| neurodegeneration

Outgoing (18)

TargetRelationTypeStr
CACNA1Gassociated_withgene0.60
CCScontributes_togene0.60
CACNA2D2associated_withgene0.60
CACNA1Cassociated_withgene0.60
CACNA1Iassociated_withgene0.60

Incoming (18)

SourceRelationTypeStr
CACNA1Aassociated_withgene0.60
CCScontributes_togene0.60
CACNA1Cassociated_withgene0.60
CACNA2D2associated_withgene0.60
CACNA1Fassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found