Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CACNA1D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CACNA1D |
| Chromosome | 3p21.1 |
| Protein Family | Voltage-gated calcium channel (Cav1) family |
| Function | CACNA1D encodes the α1D subunit of voltage-dependent L-type calcium channels, also known as Cav1.3 |
| Primary Expression | neurons, cardiac pacemaker cells, and endocrine cells |
| Subcellular Localization | Cell membrane, dendritic shafts, presynaptic terminals |
| Molecular Weight | 245 kDa |
| UniProt ID | [Q01658](https://www.uniprot.org/uniprot/Q01658) |
| GeneCards | CACNA1D |
| Human Protein Atlas | CACNA1D |
| α1 Subunit (CACNA1D) | Forms the transmembrane pore |
| β Subunit | Auxiliary subunit affecting trafficking and kinetics |
| α2δ Subunit | Auxiliary subunit increasing surface expression |
| γ Subunit | Modulatory subunit (in some tissues) |
| Low-Voltage Activation | Activates at potentials as negative as -50 mV (vs. -30 mV for Cav1.2) |
| Associated Diseases | neurodegeneration |
| Interactions | CACNA2D2, CACNA1I, CACNA2D1, CACNA1E, CACNA1H, CACNA1G |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CACNA1D["<b>CACNA1D</b>"]
CACNA1G["CACNA1G"]
CACNA1D -->|"associated with"| CACNA1G
CCS["CCS"]
CACNA1D -->|"contributes to"| CCS
CACNA2D2["CACNA2D2"]
CACNA1D -->|"associated with"| CACNA2D2
CACNA1C["CACNA1C"]
CACNA1D -->|"associated with"| CACNA1C
CACNA1I["CACNA1I"]
CACNA1D -->|"associated with"| CACNA1I
CACNA1A["CACNA1A"]
CACNA1A -->|"associated with"| CACNA1D
CCS["CCS"]
CCS -->|"contributes to"| CACNA1D
CACNA1C["CACNA1C"]
CACNA1C -->|"associated with"| CACNA1D
CACNA2D2["CACNA2D2"]
CACNA2D2 -->|"associated with"| CACNA1D
CACNA1F["CACNA1F"]
CACNA1F -->|"associated with"| CACNA1D
CACNA1I["CACNA1I"]
CACNA1I -->|"associated with"| CACNA1D
CACNA2D1["CACNA2D1"]
CACNA2D1 -->|"associated with"| CACNA1D
CACNA1E["CACNA1E"]
CACNA1E -->|"associated with"| CACNA1D
CACNA1H["CACNA1H"]
CACNA1H -->|"associated with"| CACNA1D
GENES["GENES"]
GENES -->|"associated with"| CACNA1D
CACNA1G["CACNA1G"]
CACNA1G -->|"associated with"| CACNA1D
GAIN["GAIN"]
GAIN -->|"contributes to"| CACNA1D
AND["AND"]
AND -->|"associated with"| CACNA1D
CACNA2D2["CACNA2D2"]
CACNA1D -->|"interacts with"| CACNA2D2
CACNA1I["CACNA1I"]
CACNA1D -->|"interacts with"| CACNA1I
CACNA2D1["CACNA2D1"]
CACNA1D -->|"interacts with"| CACNA2D1
CACNA1E["CACNA1E"]
CACNA1D -->|"interacts with"| CACNA1E
CACNA1H["CACNA1H"]
CACNA1D -->|"interacts with"| CACNA1H
CACNA1G["CACNA1G"]
CACNA1D -->|"interacts with"| CACNA1G
CACNA1A["CACNA1A"]
CACNA1D -->|"interacts with"| CACNA1A
CACNA1C["CACNA1C"]
CACNA1D -->|"interacts with"| CACNA1C
Genes["Genes"]
CACNA1D -->|"interacts with"| Genes
cacna1f["cacna1f"]
cacna1f -->|"interacts with"| CACNA1D
neurodegeneration["neurodegeneration"]
CACNA1D -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| CACNA1G | associated_with | gene | 0.60 |
| CCS | contributes_to | gene | 0.60 |
| CACNA2D2 | associated_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| CACNA1I | associated_with | gene | 0.60 |
| CACNA2D1 | associated_with | gene | 0.60 |
| CACNA1A | associated_with | gene | 0.60 |
| CACNA1F | interacts_with | gene | 0.60 |
| CACNA2D2 | interacts_with | gene | 0.50 |
| CACNA1I | interacts_with | gene | 0.50 |
| CACNA2D1 | interacts_with | gene | 0.50 |
| CACNA1E | interacts_with | protein | 0.50 |
| CACNA1H | interacts_with | protein | 0.50 |
| CACNA1G | interacts_with | protein | 0.50 |
| CACNA1A | interacts_with | gene | 0.50 |
| CACNA1C | interacts_with | gene | 0.50 |
| CACNA1E | co_expressed_with | protein | 0.50 |
| CACNA1G | co_expressed_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CACNA1A | associated_with | gene | 0.60 |
| CCS | contributes_to | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| CACNA2D2 | associated_with | gene | 0.60 |
| CACNA1F | associated_with | gene | 0.60 |
| CACNA1I | associated_with | gene | 0.60 |
| CACNA2D1 | associated_with | gene | 0.60 |
| CACNA1E | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| CACNA1G | associated_with | gene | 0.60 |
| GAIN | contributes_to | gene | 0.60 |
| CACNA1A | interacts_with | gene | 0.60 |
| CACNA1C | interacts_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| CACNA1A | co_expressed_with | gene | 0.50 |
| CACNA1C | co_expressed_with | gene | 0.50 |
| cacna1f | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||