Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CACNA2D1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CACNA2D1 encodes the alpha2 delta-1 subunit of voltage-gated calcium channels, essential for synaptic transmission and muscle function.
| Gene Symbol | CACNA2D1 |
| Full Name | Calcium Channel Voltage-Dependent Subunit Alpha2 Delta 1 |
| Aliases | CaB1, CACNA2, α2δ1 |
| Chromosome | 7q21.11 |
| Protein Type | Channel |
| Function | is a critical component of L-type and N-type calcium channels, modulating channel trafficking, gating, and synaptic localization. |
| Primary Expression | High in brain, skeletal muscle, heart |
| Amino Acids | 1256 aa |
| UniProt ID | Q13926 |
| NCBI Gene ID | 781 |
| Ensembl ID | ENSG00000153991 |
| OMIM | 114204 |
| GeneCards | CACNA2D1 |
| Human Protein Atlas | CACNA2D1 |
| Protein Class | Calcium channel auxiliary subunit |
| Associated Diseases | neurodegeneration |
| Interactions | CACNA1E, CACNA1H, CACNA1G, CACNA1A, CACNA1C, CACNA2D2 |
| KG Connections | 42 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CACNA2D1["<b>CACNA2D1</b>"]
CACNA1E["CACNA1E"]
CACNA2D1 -->|"associated with"| CACNA1E
CACNA1H["CACNA1H"]
CACNA2D1 -->|"associated with"| CACNA1H
CACNA1D["CACNA1D"]
CACNA2D1 -->|"associated with"| CACNA1D
CACNA1G["CACNA1G"]
CACNA2D1 -->|"associated with"| CACNA1G
GAIN["GAIN"]
CACNA2D1 -->|"contributes to"| GAIN
CACNA1F["CACNA1F"]
CACNA2D1 -->|"associated with"| CACNA1F
CACNA1A["CACNA1A"]
CACNA2D1 -->|"associated with"| CACNA1A
AND["AND"]
CACNA2D1 -->|"associated with"| AND
CCS["CCS"]
CACNA2D1 -->|"contributes to"| CCS
CACNA2D2["CACNA2D2"]
CACNA2D1 -->|"associated with"| CACNA2D2
CACNA1C["CACNA1C"]
CACNA2D1 -->|"associated with"| CACNA1C
CACNA1I["CACNA1I"]
CACNA2D1 -->|"associated with"| CACNA1I
CACNA1A["CACNA1A"]
CACNA1A -->|"associated with"| CACNA2D1
CCS["CCS"]
CCS -->|"contributes to"| CACNA2D1
CACNA1C["CACNA1C"]
CACNA1C -->|"associated with"| CACNA2D1
CACNA2D2["CACNA2D2"]
CACNA2D2 -->|"associated with"| CACNA2D1
CACNA1F["CACNA1F"]
CACNA1F -->|"associated with"| CACNA2D1
CACNA1I["CACNA1I"]
CACNA1I -->|"associated with"| CACNA2D1
GENES["GENES"]
GENES -->|"associated with"| CACNA2D1
CACNA1G["CACNA1G"]
CACNA1G -->|"associated with"| CACNA2D1
CACNA1E["CACNA1E"]
CACNA1E -->|"associated with"| CACNA2D1
neurodegeneration["neurodegeneration"]
CACNA2D1 -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| CACNA1E | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| CACNA1D | associated_with | gene | 0.60 |
| CACNA1G | associated_with | gene | 0.60 |
| GAIN | contributes_to | gene | 0.60 |
| CACNA1F | associated_with | gene | 0.60 |
| CACNA1A | associated_with | gene | 0.60 |
| CCS | contributes_to | gene | 0.60 |
| CACNA2D2 | associated_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| CACNA1I | associated_with | gene | 0.60 |
| CACNA2D2 | interacts_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| CACNA1E | interacts_with | protein | 0.50 |
| CACNA1H | interacts_with | protein | 0.50 |
| CACNA1G | interacts_with | protein | 0.50 |
| CACNA1A | interacts_with | gene | 0.50 |
| CACNA1C | interacts_with | gene | 0.50 |
| CACNA2D2 | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CACNA1A | associated_with | gene | 0.60 |
| CCS | contributes_to | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| CACNA2D2 | associated_with | gene | 0.60 |
| CACNA1F | associated_with | gene | 0.60 |
| CACNA1I | associated_with | gene | 0.60 |
| CACNA1G | associated_with | gene | 0.60 |
| CACNA1E | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| CACNA1D | associated_with | gene | 0.60 |
| CACNA1A | interacts_with | gene | 0.60 |
| CACNA1C | interacts_with | gene | 0.60 |
| CACNA1E | interacts_with | gene | 0.60 |
| CACNA1F | interacts_with | gene | 0.60 |
| CACNA1G | interacts_with | gene | 0.60 |
| CACNA1H | interacts_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| CACNA1D | interacts_with | gene | 0.50 |
| CACNA2D2 | interacts_with | gene | 0.50 |
| CACNA1I | interacts_with | gene | 0.50 |
| CACNA1H | co_expressed_with | protein | 0.50 |
| CACNA1I | co_expressed_with | gene | 0.50 |
| cacna1f | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||