gene

CACNA2D1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA2D1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections
0Hypotheses
0Analyses
19Outgoing
23Incoming

Summary

CACNA2D1 encodes the alpha2 delta-1 subunit of voltage-gated calcium channels, essential for synaptic transmission and muscle function.

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🧬 Gene Info
Gene SymbolCACNA2D1
Full NameCalcium Channel Voltage-Dependent Subunit Alpha2 Delta 1
AliasesCaB1, CACNA2, α2δ1
Chromosome7q21.11
Protein TypeChannel
Functionis a critical component of L-type and N-type calcium channels, modulating channel trafficking, gating, and synaptic localization.
Primary ExpressionHigh in brain, skeletal muscle, heart
Amino Acids1256 aa
UniProt IDQ13926
NCBI Gene ID781
Ensembl IDENSG00000153991
OMIM114204
GeneCardsCACNA2D1
Human Protein AtlasCACNA2D1
Protein ClassCalcium channel auxiliary subunit
Associated Diseasesneurodegeneration
InteractionsCACNA1E, CACNA1H, CACNA1G, CACNA1A, CACNA1C, CACNA2D2
KG Connections42 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CACNA2D1 — AlphaFold Q13926 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

CACNA2D1 Gene - Calcium Channel Voltage-Dependent Subunit Alpha2 Delta 1

gene · 1037 words

PTBP2 - Polypyrimidine Tract Binding Protein 2

gene · 3381 words

L-type Calcium Channel

protein · 2039 words

CACNA2D2 Gene

gene · 1895 words

RBM25 (RNA Binding Motif 25)

gene · 1728 words

CACNG1 Gene - Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 1

gene · 1590 words

Pathway Diagram

graph TD
    CACNA2D1["<b>CACNA2D1</b>"]
    CACNA1E["CACNA1E"]
    CACNA2D1 -->|"associated with"| CACNA1E
    CACNA1H["CACNA1H"]
    CACNA2D1 -->|"associated with"| CACNA1H
    CACNA1D["CACNA1D"]
    CACNA2D1 -->|"associated with"| CACNA1D
    CACNA1G["CACNA1G"]
    CACNA2D1 -->|"associated with"| CACNA1G
    GAIN["GAIN"]
    CACNA2D1 -->|"contributes to"| GAIN
    CACNA1F["CACNA1F"]
    CACNA2D1 -->|"associated with"| CACNA1F
    CACNA1A["CACNA1A"]
    CACNA2D1 -->|"associated with"| CACNA1A
    AND["AND"]
    CACNA2D1 -->|"associated with"| AND
    CCS["CCS"]
    CACNA2D1 -->|"contributes to"| CCS
    CACNA2D2["CACNA2D2"]
    CACNA2D1 -->|"associated with"| CACNA2D2
    CACNA1C["CACNA1C"]
    CACNA2D1 -->|"associated with"| CACNA1C
    CACNA1I["CACNA1I"]
    CACNA2D1 -->|"associated with"| CACNA1I
    CACNA1A["CACNA1A"]
    CACNA1A -->|"associated with"| CACNA2D1
    CCS["CCS"]
    CCS -->|"contributes to"| CACNA2D1
    CACNA1C["CACNA1C"]
    CACNA1C -->|"associated with"| CACNA2D1
    CACNA2D2["CACNA2D2"]
    CACNA2D2 -->|"associated with"| CACNA2D1
    CACNA1F["CACNA1F"]
    CACNA1F -->|"associated with"| CACNA2D1
    CACNA1I["CACNA1I"]
    CACNA1I -->|"associated with"| CACNA2D1
    GENES["GENES"]
    GENES -->|"associated with"| CACNA2D1
    CACNA1G["CACNA1G"]
    CACNA1G -->|"associated with"| CACNA2D1
    CACNA1E["CACNA1E"]
    CACNA1E -->|"associated with"| CACNA2D1
    neurodegeneration["neurodegeneration"]
    CACNA2D1 -->|"implicated in"| neurodegeneration

Outgoing (19)

TargetRelationTypeStr
CACNA1Eassociated_withgene0.60
CACNA1Hassociated_withgene0.60
CACNA1Dassociated_withgene0.60
CACNA1Gassociated_withgene0.60
GAINcontributes_togene0.60

Incoming (23)

SourceRelationTypeStr
CACNA1Aassociated_withgene0.60
CCScontributes_togene0.60
CACNA1Cassociated_withgene0.60
CACNA2D2associated_withgene0.60
CACNA1Fassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found