gene

CACNA2D2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA2D2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

28Outgoing

32Incoming

Summary

Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2 gene involved in calcium channel function, implicated in epilepsy, ataxia, and neurodegenerative diseases including AD and PD

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🧬 Gene Info

Gene Symbol	CACNA2D2
Full Name	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2
Aliases	Alpha2delta-2 Subunit
Chromosome	3p21.31
Function	encodes a large precursor protein that undergoes post-translational processing to generate the mature alpha2 and delta subunits, which remain linked by disulfide bonds.
Primary Expression	Brain (cerebellum, hippocampus, cortex), heart, spinal cord
Molecular Weight	~130 kDa
Amino Acids	1116 aa
Exons	39
UniProt ID	Q9YXG3
NCBI Gene ID	9254
Ensembl ID	ENSG00000107438
OMIM	607117
GeneCards	CACNA2D2
Human Protein Atlas	CACNA2D2
Associated Diseases	Alzheimer's Disease, Breast Cancer, Cerebellar Atrophy, Epileptic Encephalopathy, Frontotemporal Dementia with Tau Pathology, Intermediate Coronary Lesions
Interactions	CACNA1I, CACNA2D1, CACNA1E, CACNA1H, CACNA1G, CACNA1A
KG Connections	60 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CACNA2D2 — AlphaFold Q9YXG3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CACNA2D2["CACNA2D2"]
    Epileptic_Encephalopathy["Epileptic Encephalopathy"]
    Cerebellar_Atrophy["Cerebellar Atrophy"]
    microRNA_423_5p["microRNA-423-5p"]
    Frontotemporal_Dementia_with_T["Frontotemporal Dementia with Tau Pathology"]
    Neuronal_Excitability["Neuronal Excitability"]
    Lung_Cancer["Lung Cancer"]
    Breast_Cancer["Breast Cancer"]
    Kidney_Cancer["Kidney Cancer"]
    Intermediate_Coronary_Lesions["Intermediate Coronary Lesions"]
    Alzheimer_s_Disease["Alzheimer's Disease"]
    CACNA1F["CACNA1F"]
    CACNA1I["CACNA1I"]
    CACNA2D1["CACNA2D1"]
    CACNA1E["CACNA1E"]
    CACNA1H["CACNA1H"]
    CACNA1D["CACNA1D"]
    CACNA1G["CACNA1G"]
    CACNA1A["CACNA1A"]
    CCS["CCS"]
    CACNA1C["CACNA1C"]
    CACNA2D2 -.-|"associated"| Epileptic_Encephalopathy
    CACNA2D2 -.-|"associated"| Cerebellar_Atrophy
    CACNA2D2 -->|"targets"| microRNA_423_5p
    CACNA2D2 -.-|"associated"| Frontotemporal_Dementia_with_T
    CACNA2D2 -->|"regulates"| Neuronal_Excitability
    CACNA2D2 -->|"implicated_in"| Lung_Cancer
    CACNA2D2 -->|"implicated_in"| Breast_Cancer
    CACNA2D2 -->|"implicated_in"| Kidney_Cancer
    CACNA2D2 -.-|"associated"| Intermediate_Coronary_Lesions
    CACNA2D2 -.-|"associated"| Alzheimer_s_Disease
    CACNA2D2 -.-|"associated"| CACNA1F
    CACNA2D2 -.-|"associated"| CACNA1I
    CACNA2D2 -.-|"associated"| CACNA2D1
    CACNA2D2 -.-|"associated"| CACNA1E
    CACNA2D2 -.-|"associated"| CACNA1H
    CACNA2D2 -.-|"associated"| CACNA1D
    CACNA2D2 -.-|"associated"| CACNA1G
    CACNA1A -.-|"associated"| CACNA2D2
    CCS -->|"contributes_to"| CACNA2D2
    CACNA1C -.-|"associated"| CACNA2D2
    style CACNA2D2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (28)

Target	Relation	Type	Str
Epileptic Encephalopathy	associated_with	disease	0.90
Cerebellar Atrophy	associated_with	phenotype	0.90
microRNA-423-5p	targets	entity	0.80
Frontotemporal Dementia with Tau Pathology	associated_with	disease	0.80
Neuronal Excitability	regulates	biological_process	0.80
Kidney Cancer	implicated_in	disease	0.70
Intermediate Coronary Lesions	associated_with	disease	0.70
Lung Cancer	implicated_in	disease	0.70
Breast Cancer	implicated_in	disease	0.70
Aging	therapeutic_target	disease	0.65
CACNA1F	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
Rb	associated_with	protein	0.60
Alzheimer's Disease	associated_with	disease	0.60
CACNA1I	interacts_with	gene	0.50
CACNA2D1	interacts_with	gene	0.50
CACNA1E	interacts_with	protein	0.50
CACNA1H	interacts_with	protein	0.50
CACNA1G	interacts_with	protein	0.50
CACNA1A	interacts_with	gene	0.50
CACNA1C	interacts_with	gene	0.50

Incoming (32)

Source	Relation	Type	Str
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
GAIN	contributes_to	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
CACNB3	associated_with	gene	0.60
ADRB1	associated_with	gene	0.60
CPT2	associated_with	gene	0.60
CACNA1A	interacts_with	gene	0.60
CACNA1C	interacts_with	gene	0.60
CACNA1E	interacts_with	gene	0.60
CACNA1F	interacts_with	gene	0.60
CACNA1G	interacts_with	gene	0.60
CACNA1H	interacts_with	gene	0.60
CACNA1I	interacts_with	gene	0.60
CACNA2D1	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
CDH1	therapeutic_target	gene	0.60
PER	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
CPT1A	associated_with	gene	0.60
CACNA1D	interacts_with	gene	0.50
CACNA1I	co_expressed_with	gene	0.50
CACNA2D1	co_expressed_with	gene	0.50
cacna1f	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CACNA2D2

Understanding Entity Pages

Summary

Wiki Pages (11)

CACNA2D2 Gene

CACNA1D Gene

CACNA2D1 Gene - Calcium Channel Voltage-Dependent Subunit Alpha2 Delta 1

CACNA1H Gene

CACNA1A — Calcium Channel Alpha-1A Subunit

CACNA1I Gene - Calcium Voltage-Gated Channel Subunit Alpha1 I

CACNA2D2 Protein (Alpha2delta-2 Subunit)

CACNA1D Protein

CACNB3