Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Copper Chaperone for Superoxide Dismutase - essential for SOD1 maturation and copper delivery in neurons
| Gene Symbol | CCS |
| Full Name | Copper Chaperone for Superoxide Dismutase |
| Chromosome | 11q13.2 |
| Function | CCS performs essential functions in copper homeostasis and SOD1 maturation |
| Amino Acids | 274 aa |
| Pathways | Chaperone |
| UniProt ID | O15136 |
| NCBI Gene ID | 9973 |
| Ensembl ID | ENSG00000129521 |
| OMIM | 603646 |
| GeneCards | CCS |
| Human Protein Atlas | CCS |
| Copper modulation | Modulate cellular copper to influence CCS-SOD1 interaction |
| Gene therapy | Target CCS expression for ALS |
| Antioxidant therapy | Enhance SOD1 activity through CCS pathway |
| Associated Diseases | Cardiovascular, Inflammation, Ischemia, Stroke |
| Interactions | STAT3, JARID2, UBIQUITIN, VIM, SOD1, FN1 |
| KG Connections | 52 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CCS["<b>CCS</b>"]
Ischemia{"Ischemia"}
CCS -->|"associated with"| Ischemia
Stroke{"Stroke"}
CCS -->|"associated with"| Stroke
Cardiovascular{"Cardiovascular"}
CCS -->|"associated with"| Cardiovascular
Inflammation{"Inflammation"}
CCS -->|"associated with"| Inflammation
INFLAMMATION["INFLAMMATION"]
CCS -->|"associated with"| INFLAMMATION
APOB["APOB"]
CCS -->|"associated with"| APOB
neurodegeneration["neurodegeneration"]
CCS -->|"implicated in"| neurodegeneration
IL_6["IL-6"]
IL_6 -->|"associated with"| CCS
style CCS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | inhibits | disease | 0.75 |
| Ischemia | associated_with | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Prostate Cancer | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Breast Cancer | inhibits | disease | 0.65 |
| APOB | associated_with | gene | 0.60 |
| STAT3 | inhibits | gene | 0.60 |
| JARID2 | inhibits | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| VIM | inhibits | gene | 0.60 |
| SOD1 | interacts_with | gene | 0.60 |
| CACNA1C | contributes_to | gene | 0.60 |
| CACNA2D2 | contributes_to | gene | 0.60 |
| CACNA1F | contributes_to | gene | 0.60 |
| CACNA1I | contributes_to | gene | 0.60 |
| CACNA2D1 | contributes_to | gene | 0.60 |
| CACNA1E | contributes_to | gene | 0.60 |
| CACNA1H | contributes_to | gene | 0.60 |
| CACNA1D | contributes_to | gene | 0.60 |
| CACNA1G | contributes_to | gene | 0.60 |
| CACNA1A | contributes_to | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| Oxidative Phosphorylation | associated_with | pathway | 0.60 |
| Glycolysis | inhibits | pathway | 0.60 |
| FN1 | inhibits | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| JAK | inhibits | gene | 0.60 |
| Metastasis | inhibits | pathway | 0.60 |
| Chaperone | activates | pathway | 0.60 |
| Invasion | inhibits | pathway | 0.60 |
| Jak-Stat | inhibits | pathway | 0.60 |
| AND | interacts_with | gene | 0.60 |
| Chaperone | interacts_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CACNA1A | contributes_to | gene | 0.60 |
| CACNA1G | contributes_to | gene | 0.60 |
| CACNA1E | contributes_to | gene | 0.60 |
| CACNA2D1 | contributes_to | gene | 0.60 |
| GAIN | activates | gene | 0.60 |
| CACNA1F | contributes_to | gene | 0.60 |
| CACNA1H | contributes_to | gene | 0.60 |
| CACNA1D | contributes_to | gene | 0.60 |
| CACNA1C | contributes_to | gene | 0.60 |
| CACNA1I | contributes_to | gene | 0.60 |
| IL-6 | associated_with | gene | 0.60 |
| MIRNAS | biomarker_for | gene | 0.60 |
| ATP | associated_with | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| AND | contributes_to | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||