gene

CCS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections
0Hypotheses
1Analyses
37Outgoing
15Incoming

Summary

Copper Chaperone for Superoxide Dismutase - essential for SOD1 maturation and copper delivery in neurons

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🧬 Gene Info
Gene SymbolCCS
Full NameCopper Chaperone for Superoxide Dismutase
Chromosome11q13.2
FunctionCCS performs essential functions in copper homeostasis and SOD1 maturation
Amino Acids274 aa
PathwaysChaperone
UniProt IDO15136
NCBI Gene ID9973
Ensembl IDENSG00000129521
OMIM603646
GeneCardsCCS
Human Protein AtlasCCS
Copper modulationModulate cellular copper to influence CCS-SOD1 interaction
Gene therapyTarget CCS expression for ALS
Antioxidant therapyEnhance SOD1 activity through CCS pathway
Associated DiseasesCardiovascular, Inflammation, Ischemia, Stroke
InteractionsSTAT3, JARID2, UBIQUITIN, VIM, SOD1, FN1
KG Connections52 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CCS — AlphaFold O15136 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

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Pathway Diagram

graph TD
    CCS["<b>CCS</b>"]
    Ischemia{"Ischemia"}
    CCS -->|"associated with"| Ischemia
    Stroke{"Stroke"}
    CCS -->|"associated with"| Stroke
    Cardiovascular{"Cardiovascular"}
    CCS -->|"associated with"| Cardiovascular
    Inflammation{"Inflammation"}
    CCS -->|"associated with"| Inflammation
    INFLAMMATION["INFLAMMATION"]
    CCS -->|"associated with"| INFLAMMATION
    APOB["APOB"]
    CCS -->|"associated with"| APOB
    neurodegeneration["neurodegeneration"]
    CCS -->|"implicated in"| neurodegeneration
    IL_6["IL-6"]
    IL_6 -->|"associated with"| CCS
    style CCS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (37)

TargetRelationTypeStr
Alsinhibitsdisease0.75
Ischemiaassociated_withdisease0.65
Strokeassociated_withdisease0.65
Cardiovascularassociated_withdisease0.65
Inflammationassociated_withdisease0.65

Incoming (15)

SourceRelationTypeStr
CACNA1Acontributes_togene0.60
CACNA1Gcontributes_togene0.60
CACNA1Econtributes_togene0.60
CACNA2D1contributes_togene0.60
GAINactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the specific circulating factors in exercise-conditioned plasma that me

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found