Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHROMATIN REMODELING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | CHROMATIN REMODELING |
| Key Genes/Proteins | SIRT1, AMYLOID, BDNF, P300, HDAC3, TET2 |
| Related Diseases | SENESCENCE |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
CHROMATIN_REMODELING["CHROMATIN REMODELING"]
CHROMATIN_REMODELING -->|"mediates"| Smooth_Muscle_Cell_Phenotypic_["Smooth Muscle Cell Phenotypic Alterations"]
CHROMATIN_REMODELING -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
CHROMATIN_REMODELING -->|"activates"| alcohol_use_disorder["alcohol use disorder"]
CHROMATIN_REMODELING -->|"activates"| EXTRACELLULAR_MATRIX["EXTRACELLULAR MATRIX"]
NCL["NCL"] -->|"involved_in"| CHROMATIN_REMODELING
Histone_Acetylation["Histone Acetylation"] -->|"involved_in"| CHROMATIN_REMODELING
STAT3["STAT3"] -->|"modulates"| CHROMATIN_REMODELING
NUCLEOLIN["NUCLEOLIN"] -->|"involved_in"| CHROMATIN_REMODELING
PBRM1["PBRM1"] -->|"involved_in"| CHROMATIN_REMODELING
HDAC_Inhibitors["HDAC Inhibitors"] -->|"modulates"| CHROMATIN_REMODELING
CLASS_I_HDACS["CLASS I HDACS"] -->|"regulates"| CHROMATIN_REMODELING
alcohol["alcohol"] -->|"regulates"| CHROMATIN_REMODELING| Target | Relation | Type | Str |
|---|---|---|---|
| INTERNEURONS | regulates | cell_type | 0.65 |
| ASTROCYTE | activates | cell_type | 0.60 |
| ASTROCYTE | regulates | cell_type | 0.60 |
| SENESCENCE | activates | phenotype | 0.60 |
| SENESCENCE | causes | phenotype | 0.60 |
| BDNF | inhibits | gene | 0.60 |
| BDNF | causes | gene | 0.60 |
| INFLAMMATION | implicated_in | phenotype | 0.55 |
| INTERNEURONS | expressed_in | cell_type | 0.55 |
| HIPPOCAMPUS | associated_with | brain_region | 0.50 |
| SPERMIDINE | associated_with | drug | 0.50 |
| RAPAMYCIN | associated_with | drug | 0.50 |
| DNA DAMAGE RESPONSE | associated_with | pathway | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Chromatin Remodeling-Mediated Nutrient Sensing Restoration | 0.619 | neurodegeneration | Epigenetic reprogramming in aging neuron |
| Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat | 0.517 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
epigenetics | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||