| Gene Symbol | FOXO1 |
| Full Name | Forkhead Box O1 |
| Aliases | Forkhead Box O1 transcription factor |
| Chromosome | 13q14.11 |
| Protein Type | Transcription Factor |
| Target Class | Transcription Factor |
| Function | It functions as both an activator and repressor depending on cellular context and interacting partners. |
| Mechanism of Action | Small molecule modulation of protein-DNA interactions or cofactor binding |
| Druggability | Medium (0.55) |
| Clinical Stage | Phase I |
| Molecular Weight | 70 kDa |
| Amino Acids | 655 aa |
| Exons | 4 coding exons |
| Pathways | PI3K |
| UniProt ID | Q12778 |
| NCBI Gene ID | 2308 |
| Ensembl ID | ENSG00000150907 |
| OMIM | 136351 |
| GeneCards | FOXO1 |
| Human Protein Atlas | FOXO1 |
| Associated Diseases | ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Cancer |
| Known Drugs/Compounds | RESVERATROL, RAPAMYCIN, Epigallocatechin gallate, Cinobufagin, resveratrol, SDHHQ |
| Interactions | CCL4, NR1H3, MAP3K5, SREBF2, NFE2L2, C1Q |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Transcriptional Autophagy-Lysosome Coupling |
| KG Connections | 1291 knowledge graph edges |
| Databases | GeneCardsHPASTRING |