concept

DNA DAMAGE RESPONSE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNA DAMAGE RESPONSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

246Connections

0Hypotheses

0Analyses

40Outgoing

19Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	DNA DAMAGE RESPONSE
Key Genes/Proteins	C9orf72, PARP1, SIRT6, MYC
Related Diseases	SENESCENCE, ALS, AGING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DNA_DAMAGE_RESPONSE["DNA DAMAGE RESPONSE"]
    DNA_DAMAGE_RESPONSE -->|"interacts"| Cell_Death["Cell Death"]
    DNA_DAMAGE_RESPONSE -->|"activates"| Apoptosis["Apoptosis"]
    PRMT["PRMT"] -->|"regulates"| DNA_DAMAGE_RESPONSE
    DRAGO["DRAGO"] -->|"involved_in"| DNA_DAMAGE_RESPONSE
    APE2["APE2"] -->|"participates in"| DNA_DAMAGE_RESPONSE
    SETX["SETX"] -->|"involved_in"| DNA_DAMAGE_RESPONSE
    H2AX["H2AX"] -->|"involved_in"| DNA_DAMAGE_RESPONSE
    TP53["TP53"] -->|"regulates"| DNA_DAMAGE_RESPONSE
    Autophagy["Autophagy"] -->|"interacts"| DNA_DAMAGE_RESPONSE
    ATM["ATM"] -->|"inhibits"| DNA_DAMAGE_RESPONSE
    P53["P53"] -->|"inhibits"| DNA_DAMAGE_RESPONSE
    AND["AND"] -->|"inhibits"| DNA_DAMAGE_RESPONSE

Outgoing (51)

Target	Relation	Type	Str
ALS	causes	disease	0.65
AGING	implicated_in	phenotype	0.60
AGING	stabilizes	phenotype	0.60
PARP1	associated_with	gene	0.50
C9orf72	associated_with	gene	0.50
APOPTOSIS	associated_with	phenotype	0.50
SIRT6	associated_with	gene	0.50
MYC	associated_with	gene	0.50
SIRT1	associated_with	gene	0.50
CHLOROQUINE	associated_with	drug	0.45
RAPAMYCIN	associated_with	drug	0.45
CELL DEATH	associated_with	phenotype	0.45
SLC7A11	associated_with	gene	0.45
CANCER	associated_with	disease	0.45
GPX4	associated_with	gene	0.45
CGAS	associated_with	gene	0.45
ROS	associated_with	phenotype	0.45
HUNTINGTIN	associated_with	protein	0.45
DEMENTIA	associated_with	disease	0.45
SQSTM1	associated_with	gene	0.45
NEURON	associated_with	cell_type	0.45
BECN1	associated_with	gene	0.45
DNMT1	associated_with	gene	0.45
TFEB	associated_with	gene	0.45
ATG7	associated_with	gene	0.45
ULK1	associated_with	gene	0.45
GABA	associated_with	phenotype	0.45
ALS	associated_with	disease	0.45
AGING	associated_with	phenotype	0.45
LYMPHOMA	associated_with	disease	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
OLIGODENDROCYTES	associated_with	cell_type	0.45
NEURONS	associated_with	cell_type	0.45
MACROPHAGE	associated_with	cell_type	0.45
INFLAMMATION	associated_with	phenotype	0.45
RELA	associated_with	gene	0.45
MOTOR NEURONS	associated_with	cell_type	0.45
MITOPHAGY	associated_with	phenotype	0.45
VCP	associated_with	gene	0.45
TP53	associated_with	gene	0.45

Incoming (195)

Source	Relation	Type	Str
PARP1	involved_in	entity	0.90
PRMT1	regulates	entity	0.85
PRMT5	regulates	entity	0.85
C9orf72	causes	gene	0.70
C9orf72	inhibits	gene	0.70
PARP1	regulates	gene	0.70
SENESCENCE	causes	phenotype	0.70
SIRT6	interacts_with	gene	0.70
PARP1	activates	gene	0.70
MYC	activates	gene	0.65
SIRT6	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	phenotype	0.50
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
CHLOROQUINE	associated_with	drug	0.45
SPINAL MUSCULAR ATROPHY	associated_with	disease	0.45
CHROMATIN REMODELING	associated_with	phenotype	0.45
AXONAL DEGENERATION	associated_with	phenotype	0.45
SPINOCEREBELLAR ATAXIA	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DNA DAMAGE RESPONSE

Understanding Entity Pages

Wiki Pages (20)

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