concept

INTERNEURONS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERNEURONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

322Connections

14Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	INTERNEURONS
Summary	Page for Interneurons
Related Diseases	ACETYLCHOLINE, SYNAPTIC PLASTICITY, MICROGLIAL ACTIVATION
Linked Hypotheses	16 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Interneurons

cell · 811 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    INTERNEURONS["INTERNEURONS"]
    INTERNEURONS -->|"interacts"| NEURON["NEURON"]
    INTERNEURONS -->|"promotes"| NEURONS["NEURONS"]
    CORTEX["CORTEX"] -->|"expressed in"| INTERNEURONS
    INTERNEURON["INTERNEURON"] -->|"promotes"| INTERNEURONS
    HIPPOCAMPUS["HIPPOCAMPUS"] -->|"expressed in"| INTERNEURONS

Outgoing (88)

Target	Relation	Type	Str
NEURON	interacts_with	cell_type	0.95
ACETYLCHOLINE	inhibits	phenotype	0.70
SYNAPTIC PLASTICITY	inhibits	phenotype	0.70
SYNAPTIC PLASTICITY	produces	phenotype	0.70
SYNAPTIC PLASTICITY	protects_against	phenotype	0.70
SYNAPTIC PLASTICITY	activates	phenotype	0.70
NEURON	promotes	cell_type	0.65
NEURONS	promotes	cell_type	0.65
NEURON	reduces	cell_type	0.65
NEURONS	reduces	cell_type	0.65
NEURON	inhibits	cell_type	0.65
SEPSIS	regulates	disease	0.65
NEURON	expressed_in	cell_type	0.60
NEURONS	expressed_in	cell_type	0.60
NEURON	causes	cell_type	0.60
NEURONS	causes	cell_type	0.60
NEURON	protects_against	cell_type	0.60
NEURONS	protects_against	cell_type	0.60
NEURON	regulates	cell_type	0.60
NEURONS	regulates	cell_type	0.60
NEURON	targets	cell_type	0.60
NEURONS	targets	cell_type	0.60
NEURON	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
PREFRONTAL	activates	brain_region	0.60
PREFRONTAL	inhibits	brain_region	0.60
NEURON	contributes_to	cell_type	0.60
NEURONS	contributes_to	cell_type	0.60
NEURON	impairs	cell_type	0.60
NEURONS	impairs	cell_type	0.60
NEURODEGENERATION	biomarker_for	disease	0.60
NEURON	biomarker_for	cell_type	0.60
NEURONS	biomarker_for	cell_type	0.60
NEURON	associated_with	cell_type	0.60
NEURONS	associated_with	cell_type	0.60
PYRAMIDAL	causes	cell_type	0.60
THALAMUS	promotes	brain_region	0.60
PYRAMIDAL	regulates	cell_type	0.60
SYN1	expressed_in	gene	0.60
CORTEX	participates_in	brain_region	0.55
NEURON	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
SLEEP	co_discussed	entity	0.50
SCHIZOPHRENIA	regulates	disease	0.50
STRIATUM	therapeutic_target	brain_region	0.50
STRIATUM	regulates	brain_region	0.50
THALAMUS	regulates	brain_region	0.50
CEREBRAL CORTEX	regulates	concept	0.50
L-DOPA	associated_with	drug	0.50
CA3	associated_with	brain_region	0.50

Incoming (234)

Source	Relation	Type	Str
CORTEX	expressed_in	brain_region	0.95
NEURONS	produces	cell_type	0.70
CA3	activates	brain_region	0.70
MICROGLIAL ACTIVATION	causes	phenotype	0.70
INTERNEURON	promotes	cell_type	0.65
INTERNEURON	reduces	cell_type	0.65
CORTEX	targets	brain_region	0.65
HIPPOCAMPUS	expressed_in	brain_region	0.65
NEUROGENESIS	produces	phenotype	0.65
GABA	produces	phenotype	0.65
BDNF	targets	gene	0.65
GDNF	produces	gene	0.65
VALPROATE	modifies	drug	0.65
CHROMATIN REMODELING	regulates	phenotype	0.65
CA3	targets	brain_region	0.65
LRRK2	inhibits	gene	0.65
CORTEX	regulates	brain_region	0.60
INTERNEURON	expressed_in	cell_type	0.60
INTERNEURON	causes	cell_type	0.60
INTERNEURON	protects_against	cell_type	0.60
INTERNEURON	regulates	cell_type	0.60
APP	targets	gene	0.60
GABAERGIC	targets	cell_type	0.60
INTERNEURON	targets	cell_type	0.60
CORTEX	activates	brain_region	0.60
GABAERGIC	activates	cell_type	0.60
INTERNEURON	activates	cell_type	0.60
FRONTAL	activates	brain_region	0.60
FRONTAL	inhibits	brain_region	0.60
CORTEX	contributes_to	brain_region	0.60
INTERNEURON	contributes_to	cell_type	0.60
INTERNEURON	impairs	cell_type	0.60
CORTEX	biomarker_for	brain_region	0.60
GABAERGIC	expressed_in	cell_type	0.60
AUTISM	contributes_to	disease	0.60
BDNF	mediates	gene	0.60
GABAERGIC	associated_with	cell_type	0.60
CHOLINERGIC	expressed_in	cell_type	0.60
CHOLINERGIC	contributes_to	cell_type	0.60
NEUROGENESIS	stabilizes	phenotype	0.60
L-DOPA	expressed_in	drug	0.60
NEUROINFLAMMATION	implicated_in	phenotype	0.60
AUTISM	depleted_in	disease	0.55
CHROMATIN REMODELING	expressed_in	phenotype	0.55
MICROGLIA	expressed_in	cell_type	0.55
INTERNEURON	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
GABA	co_discussed	entity	0.50
GABAergic	co_discussed	entity	0.50
CORTEX	inhibits	brain_region	0.50

Targeting Hypotheses (14)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.660	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop optogenetic targeting PV interneurons to restore	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.578	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.568	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.538	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026
Duloxetine Improves Early Clinical Outcomes Including Range of Motion, Functiona [PMID:41934361]	Han SC, Han J, Min YK, Han JW, Jeong HJ	Am J Sports Med	2026
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987]	Vadalà A, Benelli C, Suraci F, Carta B,	Arch Orthop Trauma Surg	2026
Modeling and simulation of conducting airways during continuous high-frequency o [PMID:41941967]	Huang X, Francis I, Gu Y, Saha SC	Respir Physiol Neurobiol	2026
Potential antidepressant properties of aminophylline in male mice exposed to chr [PMID:41945313]	Samante FI, Galangue CG, Avelino DC, Bel	Pharmacol Rep	2026
Robot-assisted immediate implant placement with the socket shield technique in t [PMID:41963213]	Wu J, Lin B, Yang S, Xu S, Li S	J Prosthet Dent	2026
Fate plasticity of interneuron specification. [PMID:40264797]	Mostajo-Radji MA, Leon WRM, Breevoort A,	iScience	2025
Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475]	Bershteyn M, Zhou H, Fuentealba L, Chen	Neuron	2025
Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284]	Walsh RM, Crabtree GW, Kalpana K, Jubier	Neuron	2025
Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404]	Qi C, Sima W, Mao H, Hu E, Ge J et al.	Nat Commun	2025
Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329]	Morabito A, Zerlaut Y, Dhanasobhon D, Be	Neuron	2025
Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040]	Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK	Autophagy	2024
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nat Neurosci	2024
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656]	Wang W, Lu J, Pan N, Zhang H, Dai J et a	Front Immunol	2024
Cortical assembloids support the development of fast-spiking human PVALB+ cortic [PMID:39651135]	Walsh RM, Crabtree GW, Kalpana K, Jubier	bioRxiv	2024
Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373]	Fisher J, Verhagen M, Long Z, Moissidis	Neuron	2024
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473]	Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a	Adv Sci (Weinh)	2024
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024
Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213]	Mòdol L, Moissidis M, Selten M, Oozeer F	Neuron	2024
De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258]	Tang S, Conte V, Zhang DJ, Žedaveinytė R	Science	2024

INTERNEURONS

Understanding Entity Pages

Wiki Pages (21)

Interneurons

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Atypical Parkinsonism

calcium-dysregulation-comparison

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Therapeutics

Neurons — Cell Type Hierarchy

Frontotemporal Dementia (FTD) Mechanistic Pathway

GRIA3 Gene

Alzheimer's Disease

CNTN5 — Contactin 5

CLCN10 — Chloride Voltage-Gated Channel 10

Oligodendrocytes

ncam2

gabaergic-dysfunction

CNTN6 — Contactin 6

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

protective-strategies-cbs-psp

CNTN4 — Contactin 4