gene

CXCR5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCR5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

15Outgoing

1Incoming

Summary

CXCR5 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Autoimmune, Cancer, Colorectal Cancer. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CXCR5
Full Name	C-X-C Chemokine Receptor Type 5
Aliases	CD185, BLR1, Munchen's, RB1
Chromosome	11q23.3
Protein Family	Chemokine receptors (GPCR family)
Protein Type	Receptor
Function	is a G protein-coupled receptor that binds specifically to the chemokine CXCL13 (also known as BLC, BCA-1, and B lymphocyte chemoattractant).
Amino Acids	372 aa
Exons	5
Gene Type	Protein coding
Pathways	NF-κB
UniProt ID	P41970
NCBI Gene ID	935
Ensembl ID	ENSG00000169679
OMIM	601745
GeneCards	CXCR5
Human Protein Atlas	CXCR5
Associated Diseases	Cancer, Colorectal Cancer
Interactions	CX3CL1, CCL25, CX3CR1, TGF, CD4
KG Connections	16 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CXCR5 — AlphaFold P41970 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CXCR5["<b>CXCR5</b>"]
    Tumor{"Tumor"}
    CXCR5 -->|"therapeutic target"| Tumor
    Autoimmune{"Autoimmune"}
    CXCR5 -->|"therapeutic target"| Autoimmune
    CX3CL1["CX3CL1"]
    CXCR5 -->|"activates"| CX3CL1
    CCL25["CCL25"]
    CXCR5 -->|"activates"| CCL25
    CX3CR1["CX3CR1"]
    CXCR5 -->|"activates"| CX3CR1
    neurodegeneration["neurodegeneration"]
    CXCR5 -->|"implicated in"| neurodegeneration
    style CXCR5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
CX3CL1	activates	gene	0.60
CCL25	activates	gene	0.60
CX3CR1	activates	gene	0.60
DNA	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	regulates	gene	0.60
Dna Methylation	associated_with	pathway	0.60
Epigenetic	regulates	pathway	0.60
TGF	activates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60

Incoming (1)

Source	Relation	Type	Str
CD4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CXCR5

Understanding Entity Pages

Summary

Wiki Pages (6)

CXCR5 Gene

G-Protein Coupled Receptor Signaling in Parkinson's Disease

CCR7 Gene (C-C Chemokine Receptor Type 7)

CXCR4 Gene