pathway

TGF-beta signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGF-beta signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

242Connections

0Hypotheses

0Analyses

22Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	TGF-beta signaling
Key Genes/Proteins	AMBRA1, ALK5, SMAD2, TGF, IL-10, SNCA
Related Pathways	unfolded protein response, NF-kB signaling, miRNA

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TGF_beta_signaling["TGF-beta signaling"] -.->|"inhibits"| Mgnd_Response["Mgnd Response"]
    style Mgnd_Response fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"active in"| macrophages["macrophages"]
    style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"active in"| endothelial_cells["endothelial cells"]
    style endothelial_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TGF_beta_signaling["TGF-beta signaling"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AMBRA1["AMBRA1"] -->|"activates"| TGF_beta_signaling["TGF-beta signaling"]
    style AMBRA1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"crosstalk with"| TGF_beta_signaling["TGF-beta signaling"]
    style NF_kB_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ITGB8["ITGB8"] -->|"activates"| TGF_beta_signaling["TGF-beta signaling"]
    style ITGB8 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    miRNA["miRNA"] -->|"regulates"| TGF_beta_signaling["TGF-beta signaling"]
    style miRNA fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    EGFR["EGFR"] -->|"participates in"| TGF_beta_signaling["TGF-beta signaling"]
    style EGFR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style TGF_beta_signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (25)

Target	Relation	Type	Str
unfolded protein response	crosstalk_with	pathway	0.90
microglia	active_in	cell_type	0.90
neurons	active_in	cell_type	0.90
neural stem cells	active_in	cell_type	0.90
macrophages	active_in	cell_type	0.80
SNCA	upregulates	gene	0.80
endothelial cells	active_in	cell_type	0.70
astrocytes	active_in	cell_type	0.70
hippocampus	active_in	brain_region	0.70
epigenetic regulation	crosstalk_with	pathway	0.60
pericytes	active_in	cell_type	0.60
blood-brain barrier	active_in	brain_region	0.60
dopaminergic neurons	active_in	cell_type	0.60
thalamus	active_in	brain_region	0.60
hypothalamus	active_in	brain_region	0.60
oligodendrocytes	active_in	cell_type	0.60
spinal cord	active_in	brain_region	0.60
white matter	active_in	brain_region	0.60
mast cells	active_in	cell_type	0.60
Wnt signaling	crosstalk_with	pathway	0.60
lipid metabolism	crosstalk_with	pathway	0.60
T cells	active_in	cell_type	0.60

Incoming (217)

Source	Relation	Type	Str
AMBRA1	activates	protein	0.90
NF-kB signaling	crosstalk_with	pathway	0.90
ALK5	component_of	protein	0.90
SMAD2	component_of	protein	0.90
TGF	participates_in	gene	0.85
IL-10	participates_in	gene	0.85
miRNA	regulates	biological_process	0.80
EGFR	participates_in	gene	0.80
APP	participates_in	gene	0.80
JAK	participates_in	gene	0.80
JAK-STAT signaling	crosstalk_with	pathway	0.80
Alzheimer's disease	involves	disease	0.80
TNF	participates_in	gene	0.80
RNA	participates_in	gene	0.80
SMAD3	participates_in	gene	0.80
DYNLRB1	component_of	protein	0.80
spinal muscular atrophy	involves	disease	0.80
GDNF	participates_in	gene	0.75
IL-6	participates_in	gene	0.75
microglia	active_in	cell_type	0.75
aging	involves	disease	0.70
HMGB1	participates_in	gene	0.70
TGM2	participates_in	gene	0.70
PI3K	participates_in	gene	0.70
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.70
Parkinson's disease	involves	disease	0.70
MAPK	participates_in	gene	0.70
PRKN	participates_in	gene	0.70
neurodegeneration	involves	disease	0.70
APOE	participates_in	gene	0.70
SMAD2	participates_in	gene	0.70
FGF	participates_in	gene	0.70
SORL1	participates_in	gene	0.70
AQP1	participates_in	gene	0.70
TET2	participates_in	gene	0.70
HDAC	participates_in	gene	0.65
HIF	participates_in	gene	0.65
astrocytes	active_in	cell_type	0.65
CREB	participates_in	gene	0.65
ARG1	participates_in	gene	0.65
BACE1	participates_in	gene	0.60
FOXP3	participates_in	gene	0.60
IL10	participates_in	gene	0.60
BMAL1	participates_in	gene	0.60
C1Q	participates_in	gene	0.60
C3	participates_in	gene	0.60
TH	participates_in	gene	0.60
PPARGC1A	participates_in	gene	0.60
AKT	participates_in	gene	0.60
GBM	participates_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TGF-beta signaling

Understanding Entity Pages

Wiki Pages (20)

Therapeutics

TGF-β Signaling in Parkinson's Disease

UCHL1 (PARK5) Pathway in Parkinson's Disease

SMAD3 — SMAD Family Member 3