TGF

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TGF-beta Receptor 1 (TGFβR1) Protein

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graph TD
    TGF(["TGF"])
    style TGF fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    TNF["TNF"]
    unfolded_protein_response(("unfolded protein response"))
    TGF_beta_signaling(("TGF-beta signaling"))
    neurotrophin_signaling(["neurotrophin signaling"])
    IL_10(["IL-10"])
    NF_kB_signaling(("NF-kB signaling"))
    microglia["/"microglia"/"]
    oxidative_stress_response(("oxidative stress response"))
    astrocytes["/"astrocytes"/"]
    BDNF["BDNF"]
    neurons["/"neurons"/"]
    neuroinflammation["neuroinflammation"]
    GDNF["GDNF"]
    HDAC["HDAC"]
    IL_6(["IL-6"])
    HIF["HIF"]

    TGF -->|"activates"| TNF
    TGF -->|"participates_in"| unfolded_protein_response
    TGF -->|"participates_in"| TGF_beta_signaling
    TGF -->|"participates_in"| neurotrophin_signaling
    IL_10 -->|"activates"| TGF
    TGF -->|"participates_in"| NF_kB_signaling
    TGF -->|"expressed_in"| microglia
    TGF -->|"participates_in"| oxidative_stress_response
    TGF -->|"expressed_in"| astrocytes
    BDNF -->|"activates"| TGF
    TGF -->|"biomarker_for"| TNF
    TGF -->|"expressed_in"| neurons
    TGF -->|"activates"| neuroinflammation
    GDNF -->|"activates"| TGF
    HDAC -->|"activates"| TGF
    IL_6 -->|"activates"| TGF
    HIF -->|"activates"| TGF
    IL_10 -->|"biomarker_for"| TGF

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class TNF gene
    class unfolded_protein_response pathway
    class TGF_beta_signaling pathway
    class neurotrophin_signaling protein
    class IL_10 protein
    class NF_kB_signaling pathway
    class microglia mechanism
    class oxidative_stress_response pathway
    class astrocytes mechanism
    class BDNF gene
    class neurons mechanism
    class neuroinflammation protein
    class GDNF gene
    class HDAC protein
    class IL_6 protein
    class HIF protein