Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCL25: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CCL25 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, activates. Associated with Aging, Alzheimer, Autoimmune. Connected to 26 entities in the SciDEX knowledge graph.
| Gene Symbol | CCL25 |
| Chromosome | 19p13.2 |
| Protein Type | Chemokine |
| Function | CCL25 has distinct functions in immune development and homeostasis: |
| Primary Expression | High on small intestinal T cells, thymocytes, and some inflammatory cells |
| Molecular Weight | ~9.4 kDa |
| Pathways | PI3K, MAPK |
| NCBI Gene ID | 6374 |
| GeneCards | CCL25 |
| Human Protein Atlas | CCL25 |
| Protein Class | Chemokine |
| Cell Type | Expression Level |
| Thymic epithelial cells | High |
| Small intestine | High |
| Dendritic cells | Moderate |
| Associated Diseases | Depression, Inflammation, Neuroinflammation |
| Interactions | CX3CR1, CXCR5, CX3CL1 |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
CCL25["<b>CCL25</b>"]
Ms{"Ms"}
CCL25 -->|"biomarker for"| Ms
Inflammation{"Inflammation"}
CCL25 -->|"biomarker for"| Inflammation
Depression{"Depression"}
CCL25 -->|"associated with"| Depression
Tumor{"Tumor"}
CCL25 -->|"therapeutic target"| Tumor
Autoimmune{"Autoimmune"}
CCL25 -->|"therapeutic target"| Autoimmune
INFLAMMATION["INFLAMMATION"]
CCL25 -->|"biomarker for"| INFLAMMATION
CXCL10["CXCL10"]
CCL25 -->|"biomarker for"| CXCL10
Immune_Response(["Immune Response"])
CCL25 -->|"biomarker for"| Immune_Response
CX3CR1["CX3CR1"]
CCL25 -->|"activates"| CX3CR1
neurodegeneration["neurodegeneration"]
CCL25 -->|"implicated in"| neurodegeneration
CCL3["CCL3"]
CCL3 -->|"biomarker for"| CCL25
CYTOKINES["CYTOKINES"]
CYTOKINES -->|"biomarker for"| CCL25
CXCR5["CXCR5"]
CXCR5 -->|"activates"| CCL25
CX3CL1["CX3CL1"]
CX3CL1 -->|"activates"| CCL25
style CCL25 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | biomarker_for | disease | 0.65 |
| Inflammation | biomarker_for | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Autoimmune | therapeutic_target | disease | 0.65 |
| Aging | biomarker_for | disease | 0.65 |
| Neuroinflammation | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Alzheimer | biomarker_for | disease | 0.65 |
| Neurodegeneration | biomarker_for | disease | 0.65 |
| CXCL10 | biomarker_for | gene | 0.60 |
| CX3CR1 | activates | gene | 0.60 |
| CNP | associated_with | gene | 0.60 |
| MMP1 | associated_with | gene | 0.60 |
| NEFL | associated_with | gene | 0.60 |
| RBFOX3 | associated_with | gene | 0.60 |
| INFLAMMATION | biomarker_for | gene | 0.60 |
| Immune Response | biomarker_for | pathway | 0.60 |
| NEUROINFLAMMATION | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CCL3 | biomarker_for | gene | 0.60 |
| CXCR5 | activates | gene | 0.60 |
| CX3CL1 | activates | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| CYTOKINES | biomarker_for | gene | 0.60 |
| NEURODEGENERATION | biomarker_for | gene | 0.60 |
| ALZHEIMER | biomarker_for | gene | 0.60 |
| AMYLOID | biomarker_for | gene | 0.60 |
| TAU PATHOLOGY | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | biomarker_for | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||