concept

CD2AP DEFICIENCY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD2AP DEFICIENCY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

35Outgoing

25Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CD2AP DEFICIENCY
Key Genes/Proteins	TAU PATHOLOGY, P38, ALZHEIMER, AND, NEURON, CD2AP
Related Diseases	Alzheimer, Ms, ALS
Related Pathways	Apoptosis, Mapk

Wiki Pages (2)

Knowledge base pages for this entity

CD2AP Gene — CD2-Associated Protein

gene · 2828 words

→

CD2AP Synaptic Dysfunction Alzheimer's Disease Causal Chain

mechanism · 1351 words

→

Pathway Diagram

graph TD
    CD2AP_DEFICIENCY["CD2AP DEFICIENCY"]
    CD2AP_DEFICIENCY -.protects against.-> Cognitive_Deficits["Cognitive Deficits"]
    CD2AP_DEFICIENCY -->|"activates"| p38_MAPK["p38 MAPK"]
    CD2AP_DEFICIENCY -->|"activates"| neuronal_apoptosis["neuronal apoptosis"]
    CD2AP_DEFICIENCY -->|"activates"| Alzheimer["Alzheimer"]
    CD2AP_DEFICIENCY -->|"activates"| Ms["Ms"]
    CD2AP_DEFICIENCY -->|"activates"| Apoptosis["Apoptosis"]
    CD2AP_DEFICIENCY -->|"target for"| Mapk["Mapk"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| CD2AP_DEFICIENCY
    APOPTOSIS["APOPTOSIS"] -->|"activates"| CD2AP_DEFICIENCY
    AND["AND"] -->|"target for"| CD2AP_DEFICIENCY
    APP_PS1["APP/PS1"] -->|"activates"| CD2AP_DEFICIENCY
    APP["APP"] -->|"activates"| CD2AP_DEFICIENCY
    TAU["TAU"] -->|"activates"| CD2AP_DEFICIENCY
    CD2AP["CD2AP"] -->|"target for"| CD2AP_DEFICIENCY
    MAPK["MAPK"] -->|"target for"| CD2AP_DEFICIENCY

Outgoing (38)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	protects_against	disease	0.65
ALS	associated_with	disease	0.65
Apoptosis	activates	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
TAU PATHOLOGY	activates	gene	0.60
P38	therapeutic_target	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	therapeutic_target	gene	0.60
NEURON	activates	gene	0.60
CD2AP	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
TAU	activates	gene	0.60
APP	activates	gene	0.60
APP/PS1	activates	gene	0.60
Tau Phosphorylation	activates	pathway	0.60
RNA	associated_with	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
MICROGLIA	protects_against	gene	0.60
Phagocytosis	associated_with	pathway	0.60
Amyloid	protects_against	pathway	0.60
Complement	associated_with	pathway	0.60
MAPK	activates	gene	0.60
AND	activates	gene	0.60
P38	activates	gene	0.60
Mapk	activates	pathway	0.60
CD2AP	protects_against	gene	0.60
COMPLEMENT	associated_with	gene	0.60
GENES	regulates	gene	0.60
Microglia	expressed_in	cell_type	0.55
Endothelial Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (25)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	therapeutic_target	gene	0.60
APP/PS1	activates	gene	0.60
APP	activates	gene	0.60
TAU	activates	gene	0.60
CD2AP	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
P38	therapeutic_target	gene	0.60
NEURON	activates	gene	0.60
SYNAPSE	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
GENES	regulates	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
CD2AP	protects_against	gene	0.60
COMPLEMENT	associated_with	gene	0.60
ALZHEIMER	protects_against	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	associated_with	gene	0.60
CSF1R	associated_with	gene	0.60
CD2AP	activates	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
MICROGLIA	protects_against	gene	0.60
CD2AP GENE	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found