drug

dasatinib

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about dasatinib: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

98Connections

0Hypotheses

1Analyses

26Outgoing

27Incoming

No summary available yet. View on Wiki →

💊 Drug Info

Name	dasatinib
Summary	Dasatinib quercetin senolytic combination for Alzheimer's and Parkinson's disease
Key Genes/Proteins	PIK3CD, PDGFRB, ABL1, ABL2, CSF1R, NTRK3
Related Diseases	Alzheimer's disease
Related Pathways	senescence

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    dasatinib["dasatinib"] -->|"associated"| senolytic_therapy["senolytic_therapy"]
    style senolytic_therapy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -.->|"inhibits"| PDGFRB["PDGFRB"]
    style PDGFRB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -.->|"inhibits"| ABL1["ABL1"]
    style ABL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -.->|"inhibits"| ABL2["ABL2"]
    style ABL2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -.->|"inhibits"| CSF1R["CSF1R"]
    style CSF1R fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -.->|"inhibits"| senescent_cells["senescent cells"]
    style senescent_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    dasatinib["dasatinib"] -->|"treats"| epilepsy["epilepsy"]
    style epilepsy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    CSF1R_1["CSF1R"] -->|"expressed in"| dasatinib["dasatinib"]
    style CSF1R_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style dasatinib fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (71)

Target	Relation	Type	Str
senescent cells	associated_with	cell_type	0.85
senolytic_therapy	associated_with	drug	0.75
senescence	modulates	pathway	0.75
PIK3CD	targets	gene	0.75
PDGFRB	inhibits	gene	0.72
ABL1	inhibits	gene	0.72
ABL2	inhibits	gene	0.72
CSF1R	inhibits	gene	0.72
Alzheimer's disease	treats	disease	0.70
NTRK3	targets	gene	0.60
ABL2	targets	gene	0.60
PDGFRB	targets	gene	0.60
JAK2	targets	gene	0.60
ABL1	targets	gene	0.60
CSF1R	targets	gene	0.60
EPOR	targets	gene	0.60
ETV6	targets	gene	0.60
LOX	targets	gene	0.60
neurodegeneration	treats	disease	0.60
SFN	targets	gene	0.60
multiple sclerosis	treats	disease	0.60
AKT	targets	gene	0.60
APP	targets	gene	0.60
AQP4	targets	gene	0.55
BCL-2	targets	gene	0.55
STING	targets	gene	0.55

Incoming (27)

Source	Relation	Type	Str
STING PATHWAY	inhibits	pathway	0.70
APP	treats	gene	0.65
MICROGLIAL ACTIVATION	associated_with	phenotype	0.50
COGNITIVE DECLINE	associated_with	phenotype	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.50
SYNAPTIC LOSS	associated_with	phenotype	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
SENESCENCE	associated_with	phenotype	0.50
ASTROCYTES	associated_with	cell_type	0.50
PHAGOCYTOSIS	associated_with	phenotype	0.50
CGAS-STING PATHWAY	associated_with	pathway	0.50
STING PATHWAY	associated_with	pathway	0.50
RUXOLITINIB	associated_with	drug	0.45
CSF1R	associated_with	gene	0.45
ENDOTHELIAL CELLS	associated_with	cell_type	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
AMYLOID	associated_with	protein	0.45
ABL1	associated_with	gene	0.45
MITOCHONDRIAL DYSFUNCTION	associated_with	phenotype	0.45
SULFORAPHANE	associated_with	drug	0.45
DEMYELINATION	associated_with	phenotype	0.45
METFORMIN	associated_with	drug	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
RAPAMYCIN	associated_with	drug	0.45
SYNAPTIC PLASTICITY	associated_with	phenotype	0.45
INFLAMMATION	associated_with	phenotype	0.45
CSF1R	expressed_in	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

dasatinib

Understanding Entity Pages

Wiki Pages (21)

Dasatinib + Quercetin (D+Q) for Neurodegeneration

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Device Therapies Comparison for CBS/PSP

Therapeutics

Neuroprotection Strategies in Neurodegeneration

Microglial Senescence Pathway in Neurodegeneration

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Cellular Senescence in Neurodegeneration

Longevity and Rejuvenation Therapies Landscape

AD Therapeutic Approaches Ranked Scorecard

Aging vs Neurodegeneration: Mechanistic Comparison Matrix

Cellular Senescence in Neurodegeneration

Reactive Oxygen Species (ROS) Pathway

NIH Drug Repurposing Program for Neurodegenerative Diseases

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

AD Combination Therapy Matrix

Arcuate Nucleus POMC Neurons

Astrocyte Senescence Pathway in Neurodegeneration