Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COGNITIVE DYSFUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | COGNITIVE DYSFUNCTION |
Knowledge base pages for this entity
graph TD
COGNITIVE_DYSFUNCTION["COGNITIVE DYSFUNCTION"]
Rg1["Rg1"] -->|"treats"| COGNITIVE_DYSFUNCTION
Aloe_Emodin["Aloe-Emodin"] -->|"treats"| COGNITIVE_DYSFUNCTION
Uremic_Toxins["Uremic Toxins"] -->|"causes"| COGNITIVE_DYSFUNCTION
Neuroinflammation["Neuroinflammation"] -->|"causes"| COGNITIVE_DYSFUNCTION
HCRTR1["HCRTR1"] -->|"promotes"| COGNITIVE_DYSFUNCTION
Creutzfeldt_Jakob_Disease["Creutzfeldt-Jakob Disease"] -->|"causes"| COGNITIVE_DYSFUNCTION
E4A["E4A"] -->|"treats"| COGNITIVE_DYSFUNCTION| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson's Disease | associated_with | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Rg1 | treats | compound | 0.95 |
| Western Diet | causes | process | 0.95 |
| Aloe-Emodin | treats | compound | 0.90 |
| Uremic Toxins | causes | compound | 0.90 |
| amyloid beta aggregation | causes | process | 0.90 |
| Parkinson'S Disease | causes | disease | 0.90 |
| Dimethyl Fumarate | treats | drug | 0.88 |
| CELF2 | contributes_to | protein | 0.88 |
| Rg1 | protects_against | compound | 0.85 |
| HCRTR1 | promotes | gene | 0.85 |
| Creutzfeldt-Jakob Disease | causes | disease | 0.85 |
| E4A | treats | drug | 0.85 |
| DISULFIDE HMGB1 | mediates | protein | 0.85 |
| synaptic elimination | contributes_to | process | 0.85 |
| Gut-Brain Axis | involved_in | pathway | 0.85 |
| Neuroinflammation | causes | process | 0.85 |
| Mitophagy | treats | process | 0.85 |
| Prion | causes | protein | 0.85 |
| Microglia | contributes_to | cell_type | 0.85 |
| Neuroinflammation | contributes_to | process | 0.85 |
| Brain Oxidative Stress | contributes_to | process | 0.80 |
| MTOR | associated_with | pathway | 0.80 |
| Microtubule Instability | causes | phenotype | 0.80 |
| Hydrogen sulfide | protects_against | compound | 0.80 |
| Aucubin | protects_against | compound | 0.80 |
| PRKAA2 | protects_against | gene | 0.80 |
| cytoskeletal protein dysfunction | contributes_to | process | 0.80 |
| Hnrnp Mutations | contributes_to | mechanism | 0.78 |
| Blood Lipopolysaccharide | correlates_with | biomarker | 0.75 |
| Crocetin | treats | compound | 0.75 |
| Amyloid-β and tau | causes | protein | 0.70 |
| obesity | causes | disease | 0.70 |
| BMAL1 | regulates | gene | 0.70 |
| tau protein | associated_with | protein | 0.70 |
| gut microbiome dysbiosis | activates | process | 0.70 |
| neuroinflammation | causes | process | 0.70 |
| Oxidative Stress | causes | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589
neurodegeneration | 2026-04-08 | 0 hypotheses
neuroinflammation | 2026-04-08 | 0 hypotheses
synaptic biology | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||