protein

Prion

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Prion: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

325Connections

1Hypotheses

7Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	PRION
Chromosome	20p13
Molecular Weight	35 kDa
Amino Acids	253 aa
Pathways	Blood-Brain Barrier, Mapk, Protein Aggregation, Amyloid, Akt
GeneCards	PRION
Human Protein Atlas	PRION
Associated Diseases	Behavioral Abnormalities, Cognitive Dysfunction, Creutzfeldt-Jakob Disease, Dysbiosis, Motor Disorder, Neurodegenerative Diseases
Interactions	ALZHEIMER, HUNTINGTON, Proteins, PARKINSON, amyotrophic lateral sclerosis, AMYLOID
KG Connections	296 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Prion["Prion"] -->|"causes"| Creutzfeldt_Jakob_Disease["Creutzfeldt-Jakob Disease"]
    style Creutzfeldt_Jakob_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Prion["Prion"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    style Blood_Brain_Barrier fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Prion["Prion"] -->|"therapeutic target"| Mapk["Mapk"]
    style Mapk fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Prion["Prion"] -->|"regulates"| Protein_Aggregation["Protein Aggregation"]
    style Protein_Aggregation fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Prion["Prion"] -->|"activates"| Amyloid["Amyloid"]
    style Amyloid fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Prion["Prion"] -->|"causes"| Akt["Akt"]
    style Akt fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Prion["Prion"] -->|"associated"| Autophagy["Autophagy"]
    style Autophagy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PARKINSON["PARKINSON"] -->|"expressed in"| Prion["Prion"]
    style PARKINSON fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SOX2["SOX2"] -->|"therapeutic target"| Prion["Prion"]
    style SOX2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SNAP25["SNAP25"] -->|"therapeutic target"| Prion["Prion"]
    style SNAP25 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SOD1["SOD1"] -->|"therapeutic target"| Prion["Prion"]
    style SOD1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CCT2["CCT2"] -->|"therapeutic target"| Prion["Prion"]
    style CCT2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Prion fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (133)

Target	Relation	Type	Str
Creutzfeldt-Jakob Disease	causes	disease	0.95
Cognitive Dysfunction	causes	phenotype	0.85
Motor Disorder	causes	phenotype	0.85
Behavioral Abnormalities	causes	phenotype	0.85
Blood-Brain Barrier	therapeutic_target	pathway	0.55
Mapk	therapeutic_target	pathway	0.55
Protein Aggregation	regulates	pathway	0.55
Amyloid	activates	pathway	0.55
Protein Aggregation	activates	pathway	0.55
Amyloid	therapeutic_target	pathway	0.55
Akt	causes	pathway	0.55
Autophagy	associated_with	pathway	0.55
Protein Aggregation	associated_with	pathway	0.55
Mitochondrial Function	regulates	pathway	0.55
Mitophagy	associated_with	pathway	0.55
Oxidative Stress	contributes_to	pathway	0.55
Toll-Like Receptor	contributes_to	pathway	0.55
Akt	regulates	pathway	0.55
Pi3K	regulates	pathway	0.55
Protein Aggregation	causes	pathway	0.55
Apoptosis	causes	pathway	0.55
ALZHEIMER	interacts_with	gene	0.50
HUNTINGTON	interacts_with	gene	0.50
NEURODEGENERATIVE DISORDERS	interacts_with	concept	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
HUNTINGTON'S	interacts_with	concept	0.50
SYNUCLEIN	interacts_with	concept	0.50
disease	associated_with	disease	0.50
inflammation	regulates	pathway	0.50
ALZHEIMER	regulates	gene	0.50
PARKINSON	regulates	gene	0.50
DEMENTIA	regulates	gene	0.50
amyotrophic lateral sclerosis	regulates	gene	0.50
HUNTINGTON	regulates	gene	0.50
FRONTOTEMPORAL DEMENTIA	regulates	disease	0.50
NEURONS	regulates	concept	0.50
ALZHEIMER'S	regulates	concept	0.50
PARKINSON'S	regulates	concept	0.50
FRONTOTEMPORAL	regulates	concept	0.50
HUNTINGTON'S	regulates	concept	0.50
Prion Disease	associated_with	disease	0.50
ALZHEIMER	expressed_in	gene	0.50
PARKINSON	expressed_in	gene	0.50
HUNTINGTON	expressed_in	gene	0.50
disease	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
PARKINSON'S	expressed_in	concept	0.50
HUNTINGTON'S	expressed_in	concept	0.50
disease	causes	disease	0.50

Incoming (192)

Source	Relation	Type	Str
PARKINSON	expressed_in	gene	0.65
SOX2	therapeutic_target	gene	0.65
SNAP25	therapeutic_target	gene	0.65
SOD1	therapeutic_target	gene	0.65
CCT2	therapeutic_target	gene	0.65
GAPDH	therapeutic_target	gene	0.65
HUNTINGTON	expressed_in	gene	0.65
GFAP	therapeutic_target	gene	0.65
CDC42	therapeutic_target	gene	0.65
HSP90AB1	therapeutic_target	gene	0.65
ACTB	therapeutic_target	gene	0.65
ALZHEIMER	therapeutic_target	gene	0.65
PSMD14	therapeutic_target	gene	0.65
FN1	therapeutic_target	gene	0.65
SNCA	therapeutic_target	gene	0.65
EGFR	therapeutic_target	gene	0.65
PSMA3	therapeutic_target	gene	0.65
AND	expressed_in	gene	0.65
GENES	expressed_in	gene	0.65
ATP5A1	therapeutic_target	gene	0.65
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.65
GRIA1	therapeutic_target	gene	0.65
MAPK1	therapeutic_target	gene	0.65
ACTG1	therapeutic_target	gene	0.65
YWHAZ	therapeutic_target	gene	0.65
MYC	associated_with	gene	0.65
ALZHEIMER	interacts_with	gene	0.65
AND	associated_with	gene	0.65
NEURODEGENERATIVE DISEASES	associated_with	gene	0.65
TAU	associated_with	gene	0.65
ALZHEIMER DISEASE	interacts_with	gene	0.65
NEUROTOXICITY	associated_with	gene	0.65
AND	contributes_to	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.65
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.65
OPTN	associated_with	gene	0.65
ALS	regulates	gene	0.65
MOTOR NEURONS	associated_with	gene	0.65
AND	regulates	gene	0.65
FUS	associated_with	gene	0.65
C9ORF72	associated_with	gene	0.65
GENES	associated_with	gene	0.65
UBQLN2	associated_with	gene	0.65
GAIN	associated_with	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.65
ALS	activates	gene	0.65
PARKINSON	activates	gene	0.65
AMYLOID	activates	gene	0.65
ALZHEIMER	activates	gene	0.65
AND	activates	gene	0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Enteric Nervous System Prion-Like Propagation Blockade	0.440	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (7)

Scientific analyses that reference this entity

What are the specific molecular determinants that govern tau strain selection du

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.583

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

neurodegeneration | 2026-04-14 | 0 hypotheses

Investigate prion-like spreading of tau pathology through connected brain region

neurodegeneration | 2026-04-04 | 0 hypotheses

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-03 | 1 hypotheses Top: 0.512

Related Papers (18)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symp [PMID:36965781]	["Ishola IO", "Awogbindin IO", "Olubodun	Neurotoxicology	2023	1
Toll-like receptor expression in the blood and brain of patients and a mouse mod [PMID:25522431]	Drouin-Ouellet J, St-Amour I, Saint-Pier	The international journal of n	2014	1
Glial Cells in the Early Stages of Neurodegeneration: Pathogenesis and Therapeut [PMID:41465422]	Ahremenko E, Andreev A, Apushkin D, Kork	International journal of molec	2025	0
Co-exposure to polystyrene nanoplastics and glyphosate exacerbates NETs-mediated [PMID:40554107]	["Zeng H", "Qi J", "Chen Q", "Zhang R",	Ecotoxicology and environmenta	2025	0
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431]	Wang W, Wang Y, Wang F, Xie G, Liu S, Li	Phytomedicine : international	2024	0
Limonin (LM) and its derivatives: Unveiling the neuroprotective and anti-inflamm [PMID:39117089]	["Panda S", "Kesharwani A", "Singh M", "	Fitoterapia	2024	0
The role of the microbiota in glaucoma. [PMID:37866106]	Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa	Molecular aspects of medicine	2023	0
Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut micr [PMID:35652241]	["Liu S", "Kang W", "Mao X", "Ge L", "Du	Journal of pineal research	2022	0
Contriving multi-epitope vaccine ensemble for monkeypox disease using an immunoi [PMID:36311762]	["Aziz S", "Almajhdi F", "Waqas M", "Ull	Frontiers in immunology	2022	0
Galectin-3, a rising star in modulating microglia activation under conditions of [PMID:35859075]	["Garc\u00eda-Revilla J", "Boza-Serrano	Cell death & disease	2022	0
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocyt [PMID:31790685]	["Wu S", "Zhao M", "Sun Y", "Xie M", "Le	Life sciences	2020	0
Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061]	Choi I, Zhang Y, Seegobin SP	Nat Commun	2020	0
Neuroprotection by dihydrotestosterone in LPS-induced neuroinflammation. [PMID:32087283]	Yang L, Zhou R, Tong Y, Chen P, Shen Y,	Neurobiology of disease	2020	0
Synucleinphagy: a microglial "community cleanup program" for neuroprotection. [PMID:32453651]	["Choi I", "Seegobin S", "Liang D", "Yue	Autophagy	2020	0
Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in m [PMID:30962497]	["Zhao J", "Bi W", "Xiao S", "Lan X", "C	Scientific reports	2019	0
TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Pa [PMID:31388087]	["Shao Q", "Chen Y", "Li F", "Wang S", "	Acta pharmacologica Sinica	2019	0
RETRACTED: Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammat [PMID:30884890]	["Muhammad T", "Ikram M", "Ullah R", "Re	Nutrients	2019	0
Potential safety concerns of TLR4 antagonism with irinotecan: a preclinical obse [PMID:28011980]	["Coller J", "Bowen J", "Ball I", "Wardi	Cancer chemotherapy and pharma	2017	0

Prion

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Device Therapies Comparison for CBS/PSP

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

Therapeutics

Frontotemporal Dementia (FTD) Mechanistic Pathway

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

PD Cure Roadmap

GSK-3β in Neurodegeneration

HNRNPA2B1 Protein

Synucleinopathy Mechanism

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Tau Spreading Mechanism

APOC4 — Apolipoprotein C-IV

Pathway Diagram

Outgoing (133)

Incoming (192)

Targeting Hypotheses (1)

Mentioning Analyses (7)

What are the specific molecular determinants that govern tau strain selection du

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

Investigate prion-like spreading of tau pathology through connected brain region

Tau propagation mechanisms and therapeutic interception points

Tau propagation mechanisms and therapeutic interception points

Tau propagation mechanisms and therapeutic interception points

Tau propagation mechanisms and therapeutic interception points

Related Papers (18)