Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DLGAP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DLGAP2 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, associated with, implicated in. Associated with Ms. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | DLGAP2 |
| Chromosome | 8p23.3 |
| Protein Type | Scaffold Protein |
| Function | DLGAP2 is a core component of the postsynaptic density complex, where it mediates interactions between glutamate receptors, particularly AMPA receptors, and the underlying cytoskeleton. |
| Primary Expression | the brain, particularly in: - Cerebral cortex - Hippocampus - Striatum (for DLGAP3) - [Cerebell |
| UniProt ID | O75179 |
| NCBI Gene ID | 9228 |
| Ensembl ID | ENSG00000198010 |
| GeneCards | DLGAP2 |
| Human Protein Atlas | DLGAP2 |
| Autism Spectrum Disorder | Rare variants in DLGAP2 have been identified in patients with ASD. |
| Intellectual Disability | Loss-of-function mutations contribute to intellectual disability phenotypes. |
| Obsessive-Compulsive Disorder | DLGAP2 (particularly SAPAP3/DLGAP3) has been linked to OCD-like behaviors in mouse models. |
| Associated Diseases | Ms |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DLGAP2["<b>DLGAP2</b>"]
Ms{"Ms"}
DLGAP2 -->|"associated with"| Ms
STAT3["STAT3"]
DLGAP2 -->|"expressed in"| STAT3
ARG1["ARG1"]
DLGAP2 -->|"expressed in"| ARG1
DRD2["DRD2"]
DLGAP2 -->|"expressed in"| DRD2
DNMT3A["DNMT3A"]
DLGAP2 -->|"expressed in"| DNMT3A
Epigenetic(["Epigenetic"])
DLGAP2 -->|"associated with"| Epigenetic
Akt(["Akt"])
DLGAP2 -->|"expressed in"| Akt
neurodegeneration["neurodegeneration"]
DLGAP2 -->|"implicated in"| neurodegeneration
PENK["PENK"]
PENK -->|"expressed in"| DLGAP2
NCAM1["NCAM1"]
NCAM1 -->|"expressed in"| DLGAP2
DNMT1["DNMT1"]
DNMT1 -->|"expressed in"| DLGAP2
AKT1["AKT1"]
AKT1 -->|"expressed in"| DLGAP2
COMT["COMT"]
COMT -->|"expressed in"| DLGAP2
style DLGAP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||