PENK

Understanding Entity Pages

This page aggregates everything SciDEX knows about PENK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PENK (Proenkephalin) encodes the precursor protein for enkephalin opioid peptides, which are critical for pain modulation, reward processing, and stress responses. The enkephalin-delta opioid receptor system is implicated in Alzheimer's disease, Parkinson's disease, and mood disorders.

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graph TD
    PENK["<b>PENK</b>"]
    Ms{"Ms"}
    PENK -->|"associated with"| Ms
    NCAM1["NCAM1"]
    PENK -->|"expressed in"| NCAM1
    DNMT1["DNMT1"]
    PENK -->|"expressed in"| DNMT1
    AKT1["AKT1"]
    PENK -->|"expressed in"| AKT1
    COMT["COMT"]
    PENK -->|"expressed in"| COMT
    DLGAP2["DLGAP2"]
    PENK -->|"expressed in"| DLGAP2
    STAT3["STAT3"]
    PENK -->|"expressed in"| STAT3
    ARG1["ARG1"]
    PENK -->|"expressed in"| ARG1
    DRD2["DRD2"]
    PENK -->|"expressed in"| DRD2
    DNMT3A["DNMT3A"]
    PENK -->|"expressed in"| DNMT3A
    Epigenetic(["Epigenetic"])
    PENK -->|"associated with"| Epigenetic
    Akt(["Akt"])
    PENK -->|"expressed in"| Akt
    style PENK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0