gene

NOTCH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOTCH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

509Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

NOTCH1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with ALS, Aging, Als. Connected to 299 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NOTCH1
Chromosome	9q34.3
Protein Type	Receptor
Function	The first cleavage is mediated by ADAM10/TACE (alpha-secretase), and the second by gamma-secretase, releasing the Notch intracellular domain (NICD).
Primary Expression	Cerebral cortex, Hippocampus, Neural stem cells, Vascular endothelium
Molecular Weight	272 kDa
Pathways	NOTCH, Notch, Notch signaling, Notch Signaling
UniProt ID	P46531
NCBI Gene ID	4851
Ensembl ID	ENSG00000148400
OMIM	190198
GeneCards	NOTCH1
Human Protein Atlas	NOTCH1
Symbol [@pierfelice2011] NOTCH1 [@grotewiel2020] [@song2022] Full Name	Neurogenic Locus Notch Homolog Protein 1
Associated Diseases	ALS, Alzheimer, Alzheimer's Disease, Autoimmune, Cancer
Interactions	DLK2, GFAP, NF1, TRPM2, FOXO1, DELTEX1
KG Connections	506 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NOTCH1 — AlphaFold P46531 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NOTCH1["NOTCH1"]
    NOTCH1 -->|"causes"| ESCC["ESCC"]
    NOTCH1 -->|"regulates"| thymocyte_specification["thymocyte specification"]
    NOTCH1 -->|"regulates"| thymocyte_development["thymocyte development"]
    NOTCH1 -->|"interacts"| DELTEX1["DELTEX1"]
    NOTCH1 -->|"upregulates"| TREM2["TREM2"]
    NOTCH1 -->|"upregulates"| MHC_I["MHC-I"]
    NOTCH1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    NOTCH1 -->|"activates"| Alzheimer["Alzheimer"]
    NOTCH1 -->|"activates"| Ms["Ms"]
    NOTCH1 -->|"activates"| Als["Als"]
    DLL4["DLL4"] -->|"activates"| NOTCH1
    KIF2A["KIF2A"] -->|"interacts"| NOTCH1
    CNTN6["CNTN6"] -->|"interacts"| NOTCH1
    PIEZO1["PIEZO1"] -->|"regulates"| NOTCH1
    HNRNPA2B1["HNRNPA2B1"] -->|"activates"| NOTCH1
    CSNK2A1["CSNK2A1"] -->|"regulates"| NOTCH1
    SOX2["SOX2"] -->|"inhibits"| NOTCH1
    EGF["EGF"] -->|"expressed in"| NOTCH1
    GFAP["GFAP"] -->|"inhibits"| NOTCH1
    NESTIN["NESTIN"] -->|"expressed in"| NOTCH1

Outgoing (318)

Target	Relation	Type	Str
ESCC	causes	disease	0.90
Notch	inhibits	pathway	0.90
DNA Damage	regulates	process	0.85
Lymphatic Sprouting	involved_in	process	0.85
Als	activates	disease	0.85
Als	expressed_in	disease	0.85
Inflammation	activates	disease	0.85
thymocyte specification	regulates	phenotype	0.80
thymocyte development	regulates	phenotype	0.80
DELTEX1	interacts_with	gene	0.80
TREM2	upregulates	gene	0.80
EGFR signalling	upstream_of	pathway	0.80
Notch signaling	participates_in	pathway	0.80
MHC-I	upregulates	protein	0.80
Alzheimer's Disease	involved_in	disease	0.80
Notch	expressed_in	pathway	0.80
Neurodegeneration	activates	disease	0.75
Ischemia	activates	disease	0.75
Als	associated_with	disease	0.75
Als	inhibits	disease	0.75
Neuroinflammation	activates	disease	0.75
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
Cancer	associated_with	disease	0.75
Als	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Alzheimer's Disease	associated_with	disease	0.75
Neural Progenitor Cells	expressed_in	cell_type	0.70
Angiogenesis	activates	pathway	0.70
Angiogenesis	regulates	pathway	0.70
Notch	activates	pathway	0.70
Differentiation	inhibits	pathway	0.70
Notch	therapeutic_target	pathway	0.70
IL-6	activates	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
T cells	expressed_in	cell_type	0.70
STING	treats	gene	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Als	regulates	disease	0.65
Autoimmune	activates	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Cirrhosis	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Lymphoma	associated_with	disease	0.65
Cancer	regulates	disease	0.65

Incoming (191)

Source	Relation	Type	Str
DLL4	activates	protein	0.90
ORAI1	downregulates	protein	0.90
PSEN1	cleaves	gene	0.85
CNTN6	interacts_with	gene	0.80
BDNF	activates	gene	0.70
PI3K	therapeutic_target	gene	0.70
VEGFA	regulates	gene	0.65
PSEN1	causes	gene	0.65
TNF	inhibits	gene	0.65
TH	activates	gene	0.65
ISCHEMIA	inhibits	disease	0.65
CYTOKINES	produces	phenotype	0.65
INFLAMMATION	inhibits	phenotype	0.65
MELATONIN	regulates	drug	0.65
MELATONIN	protects_against	drug	0.65
PIEZO1	regulates	gene	0.60
HNRNPA2B1	activates	gene	0.60
CSNK2A1	regulates	gene	0.60
SOX2	inhibits	gene	0.60
EGF	expressed_in	gene	0.60
GFAP	inhibits	gene	0.60
NESTIN	expressed_in	gene	0.60
ALDH1L1	expressed_in	gene	0.60
DLK2	inhibits	gene	0.60
NGF	activates	gene	0.60
DCX	activates	gene	0.60
HES1	expressed_in	gene	0.60
NESTIN	activates	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
ALDH1L1	inhibits	gene	0.60
EGF	inhibits	gene	0.60
NESTIN	inhibits	gene	0.60
STAT3	activates	gene	0.60
MTOR	expressed_in	gene	0.60
TLR4	activates	gene	0.60
PI3K	expressed_in	gene	0.60
SOD2	activates	gene	0.60
AKT	expressed_in	gene	0.60
SOD1	activates	gene	0.60
NOTCH3	activates	gene	0.60
FLCN	activates	gene	0.60
NSD2	inhibits	gene	0.60
TP53	associated_with	gene	0.60
MYC	inhibits	gene	0.60
AKT1	activates	gene	0.60
RBPJ	regulates	gene	0.60
LRP6	regulates	gene	0.60
IGF2BP2	activates	gene	0.60
STING	regulates	gene	0.60
ABCB1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NOTCH1

Understanding Entity Pages

Summary

Wiki Pages (21)

NOTCH1 Gene

HNRNPA2B1 Protein

Notch Signaling Pathway in Neurodegeneration

Neurogenesis

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

Remyelination in Neurodegeneration

Gamma-Secretase Complex (γ-Secretase)

GLI1 — GLI Family Zinc Finger 1

Demyelination

Neuronal Migration

NICASTRIN Gene

TRIM32 Gene

Oligodendrocyte Precursor Differentiation Failure in Neurodegeneration

Notch2 Protein

Adult Hippocampal Neurogenesis: Impaired in Alzheimer's Disease, Enhanced in Superagers

PSEN1 — Presenilin 1

NOTCH2 — Notch Receptor 2

Notch Signaling in Parkinson's Disease

KIF2A — Kinesin Family Member 2A