Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FBXL7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | FBXL7 |
| Key Genes/Proteins | Survivin, UBIQUITIN, FOXP1, DNA, AURKA, AND |
| Related Diseases | Cancer, Aging |
| Related Pathways | Ubiquitin-Proteasome, Proteasome |
Knowledge base pages for this entity
graph TD
FBXL7["FBXL7"]
FBXL7 -->|"degrades"| Survivin["Survivin"]
FBXL7 -->|"regulates"| Cancer["Cancer"]
FBXL7 -->|"activates"| Aging["Aging"]
FBXL7 -->|"activates"| DNA["DNA"]
FBXL7 -->|"regulates"| AURKA["AURKA"]
FBXL7 -->|"regulates"| AND["AND"]
FBXL7 -->|"activates"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
AURKA -->|"regulates"| FBXL7
Survivin -->|"binds"| FBXL7
FOXP1["FOXP1"] -->|"regulates"| FBXL7
CANCER["CANCER"] -->|"regulates"| FBXL7
UBIQUITIN["UBIQUITIN"] -->|"activates"| FBXL7
DNA -->|"activates"| FBXL7
SURVIVIN["SURVIVIN"] -->|"regulates"| FBXL7
AND -->|"regulates"| FBXL7| Target | Relation | Type | Str |
|---|---|---|---|
| Survivin | binds | protein | 0.95 |
| UBIQUITIN | mediates | protein | 0.95 |
| Survivin | targets | protein | 0.92 |
| Cancer | regulates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| DNA | activates | gene | 0.60 |
| AURKA | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| Ubiquitin-Proteasome | activates | pathway | 0.60 |
| Proteasome | activates | pathway | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| SURVIVIN | regulates | gene | 0.60 |
| FOXP1 | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| Cell Cycle | activates | pathway | 0.60 |
| UBIQUITIN | degrades | gene | 0.60 |
| Ubiquitin-Proteasome | degrades | pathway | 0.60 |
| Actin | activates | protein | 0.60 |
| Rb | activates | protein | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||