gene

FOXP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

153Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

FOXP1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Atherosclerosis. Connected to 75 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FOXP1
Chromosome	3p13
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	embryonic brain
Molecular Weight	65 kDa
Amino Acids	583 aa
Exons	23
Pathways	Cell Cycle, Complement, Oxidative Stress, Proteasome, Ubiquitin-Proteasome
UniProt ID	P0CBB3
OMIM	613670
GeneCards	FOXP1
Human Protein Atlas	FOXP1
Full name	Forkhead Box P1
Protein	583 aa
Associated Diseases	ALS, Autism, Diabetes
Known Drugs/Compounds	quercetin
Interactions	NLRP3, UBIQUITIN, AURKA, CDKN1A, STAT3, HDAC3
KG Connections	153 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FOXP1["FOXP1"] -->|"regulates"| Cancer["Cancer"]
    FOXP1["FOXP1"] -->|"activates"| Aging["Aging"]
    FOXP1["FOXP1"] -->|"associated"| Autism["Autism"]
    FOXP1["FOXP1"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    FOXP1["FOXP1"] -->|"regulates"| Multiple_Sclerosis["Multiple Sclerosis"]
    FOXP1["FOXP1"] -->|"regulates"| Inflammation["Inflammation"]
    AURKA["AURKA"] -->|"regulates"| FOXP1["FOXP1"]
    HSPA4["HSPA4"] -->|"regulates"| FOXP1["FOXP1"]
    DNA["DNA"] -->|"activates"| FOXP1["FOXP1"]
    AGING["AGING"] -->|"therapeutic target"| FOXP1["FOXP1"]
    style FOXP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (100)

Target	Relation	Type	Str
FBXL7	upregulates	gene	0.90
FBXL7	regulates	gene	0.88
Cancer	regulates	disease	0.65
Aging	activates	disease	0.65
Autism	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Ms	regulates	disease	0.65
Aging	regulates	disease	0.65
Ms	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Inflammation	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Diabetes	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Diabetes	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	regulates	disease	0.65
ALS	activates	disease	0.65
Als	encodes	disease	0.65
DNAJB1	regulates	gene	0.60
NLRP3	activates	gene	0.60
TERT	therapeutic_target	gene	0.60
BRCA2	therapeutic_target	gene	0.60
FOXM1	associated_with	gene	0.60
FOXP4	associated_with	gene	0.60
FOXO4	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
AURKA	regulates	gene	0.60
SHH	expressed_in	gene	0.60
FOXO3	associated_with	gene	0.60
FOXA2	associated_with	gene	0.60
FOXG1	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
AVP	biomarker_for	gene	0.60
CDKN1A	inhibits	gene	0.60
STAT3	activates	gene	0.60
HDAC3	activates	gene	0.60
Rb	activates	protein	0.60
NPAS4	activates	gene	0.60
BDNF	activates	gene	0.60

Incoming (53)

Source	Relation	Type	Str
AURKA	interacts_with	gene	0.85
AURKA	inhibits	gene	0.85
AURKA	regulates	gene	0.60
HSPA4	regulates	gene	0.60
CD38	therapeutic_target	gene	0.60
FOXA2	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
FOXG1	associated_with	gene	0.60
SHH	expressed_in	gene	0.60
RHOT1	associated_with	gene	0.60
MIRO1	associated_with	gene	0.60
GABRA2	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
FOXO4	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
CDKN1A	inhibits	gene	0.60
NPAS4	activates	gene	0.60
STAT3	activates	gene	0.60
HDAC3	activates	gene	0.60
BDNF	activates	gene	0.60
CRH	biomarker_for	gene	0.60
NR3C1	biomarker_for	gene	0.60
TAC1	biomarker_for	gene	0.60
FOS	activates	gene	0.60
CDKN1A	activates	gene	0.60
quercetin	targets	drug	0.60
DNA	activates	gene	0.60
AGING	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
FOXK2	associated_with	gene	0.60
FOXD3	associated_with	gene	0.60
FOXN3	associated_with	gene	0.60
CANCER	regulates	entity	0.60
FBXL7	regulates	gene	0.60
SURVIVIN	regulates	gene	0.60
AND	regulates	gene	0.60
DNA	regulates	gene	0.60
RNA	regulates	gene	0.60
C-FOS	activates	gene	0.60
AGING	regulates	gene	0.60
AND	biomarker_for	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
AND	activates	gene	0.60
DNA	encodes	gene	0.60
RNA	encodes	gene	0.60
NR3C1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FOXP1

Understanding Entity Pages

Summary

Wiki Pages (21)

FOXP1 Gene

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

X-Linked Intellectual Disability

FOXP4 — Forkhead Box P4

Globus Pallidus Externus GABAergic Neurons

Vestibular Ganglion Neurons (Scarpa's Ganglion)

Cortical Layer 5 Pyramidal Neurons in Alzheimer's Disease

FoxP2-Expressing Neurons

Medium Spiny Neurons (MSNs)

NPAS4 Gene

Pyramidal Tract Neurons

FOXP2 Protein

Red Nucleus Neurons

Foxp1 Neurons

Globus Pallidus Externus Neurons

FOXP1 Protein

Juxtapositional Cortex (J) Neurons

Ventral Horn Motor Neurons

AURKA Gene