XPF

Understanding Entity Pages

This page aggregates everything SciDEX knows about XPF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

ERCC4 (XPF) - a critical DNA repair endonuclease involved in nucleotide excision repair, with links to xeroderma pigmentosum and neurodegenerative diseases

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graph TD
    XPF["<b>XPF</b>"]
    Cancer{"Cancer"}
    XPF -->|"activates"| Cancer
    Als{"Als"}
    XPF -->|"activates"| Als
    ALS{"ALS"}
    XPF -->|"activates"| ALS
    XRCC1["XRCC1"]
    XPF -->|"activates"| XRCC1
    PNKP["PNKP"]
    XPF -->|"activates"| PNKP
    XPG["XPG"]
    XPF -->|"inhibits"| XPG
    TDP1["TDP1"]
    XPF -->|"inhibits"| TDP1
    FEN1["FEN1"]
    XPF -->|"inhibits"| FEN1
    DNA["DNA"]
    XPF -->|"inhibits"| DNA
    SETX["SETX"]
    XPF -->|"activates"| SETX
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    XPF -->|"activates"| NEURODEGENERATIVE_DISEASES
    CANCER["CANCER"]
    XPF -->|"activates"| CANCER
    XPG -->|"inhibits"| XPF
    SETX -->|"activates"| XPF
    TDP1 -->|"inhibits"| XPF
    PNKP -->|"activates"| XPF
    FEN1 -->|"inhibits"| XPF
    DNA -->|"inhibits"| XPF
    AND["AND"]
    AND -->|"inhibits"| XPF
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    NEURODEGENERATIVE_DISORDERS -->|"activates"| XPF
    NEURODEGENERATIVE_DISEASES -->|"activates"| XPF
    style XPF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0