protein

GBA1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GBA1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Glucocerebrosidase is a 59.7 kDa enzyme essential for glycolipid metabolism in the lysosome.

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🔬 Protein Info

Gene Symbol	GBA1PROTEIN
Protein Type	Hydrolase
Function	is a lysosomal hydrolase encoded by the GBA1 gene that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose.
Subcellular Localization	</th><td>Lysosome</td></tr>
Amino Acids	536 aa
GeneCards	GBA1PROTEIN
Human Protein Atlas	GBA1PROTEIN
Associated Diseases	ALS, Aging, Alzheimer, Cancer, Gaucher Disease
Known Drugs/Compounds	BI-hTFR1, Bi-Htfr1, AAV5, AAV9, levodopa, rapamycin
Interactions	TFRC, LRRK2, JUN, TFR1, SNCA, MLKL
KG Connections	435 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GBA1 (Glucocerebrosidase) Protein

protein · 1352 words

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Pathway Diagram

graph TD
    GBA1PROTEIN["GBA1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GBA1PROTEIN -->|"implicated_in"| neurodegeneration
    style GBA1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity