Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLP-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| GLP-1R | binds | receptor | 0.95 |
| Insulin Signaling | associated_with | pathway | 0.95 |
| Insulin Signaling | promotes | pathway | 0.95 |
| synaptic function | protects_against | biological_process | 0.80 |
| cognition | improves | biological_process | 0.80 |
| learning | improves | biological_process | 0.80 |
| motor function | improves | biological_process | 0.80 |
| α-synuclein | ameliorates | protein | 0.80 |
| Ca2+ deregulation | suppresses | biological_process | 0.80 |
| ER stress | suppresses | biological_process | 0.80 |
| neuronal insulin sensitivity | enhances | biological_process | 0.80 |
| energy metabolism | enhances | biological_process | 0.80 |
| BDNF | upregulates | protein | 0.80 |
| GDNF | upregulates | protein | 0.80 |
| NEURODEGENERATION | treats | disease | 0.80 |
| Alzheimer's disease | protects_against | disease | 0.80 |
| Parkinson's disease | protects_against | disease | 0.80 |
| neurons | protects_against | cell_type | 0.80 |
| microglia | protects_against | cell_type | 0.80 |
| astrocytes | protects_against | cell_type | 0.80 |
| Aβ | ameliorates | protein | 0.80 |
| Tau | ameliorates | protein | 0.80 |
| PPARGC1A | regulates | protein | 0.70 |
| mitochondrial function | regulates | process | 0.70 |
| Alzheimer's Disease | protects_against | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Tirzepatide | activates | drug | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675
neurodegeneration | 2026-04-14 | 0 hypotheses
neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.398
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||