pathway

Insulin Signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Insulin Signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

754Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Insulin Signaling is a biological pathway involved in neurodegeneration research. Key relationships include: activates, therapeutic target, interacts with. Associated with ALS, Aging, Als. Connected to 291 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Insulin Signaling
Summary	# [Brain Insulin Signaling](/entities/brain-insulin-signaling) ## Introduction [Brain Insulin Signaling](/entities/brain-insulin-signaling) is an important component in the neurobiology of neurodegen
Key Genes/Proteins	PI3K, INSULIN RESISTANCE, INFLAMMATION, GLP-1
Related Diseases	Als, Inflammation, Aging, Insulin Resistance, Alzheimer's Disease

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Insulin_Signaling["Insulin Signaling"] -->|"interacts"| Cholesterol["Cholesterol"]
    Insulin_Signaling["Insulin Signaling"] -->|"interacts"| Glycolysis["Glycolysis"]
    Insulin_Signaling["Insulin Signaling"] -->|"interacts"| Mtor["Mtor"]
    Insulin_Signaling["Insulin Signaling"] -->|"interacts"| Synaptic_Plasticity["Synaptic Plasticity"]
    Insulin_Signaling["Insulin Signaling"] -->|"interacts"| Nf__b["Nf-Kappab"]
    JUN["JUN"] -->|"activates"| Insulin_Signaling["Insulin Signaling"]
    MTOR["MTOR"] -->|"activates"| Insulin_Signaling["Insulin Signaling"]
    AKT["AKT"] -->|"activates"| Insulin_Signaling["Insulin Signaling"]
    GENES["GENES"] -->|"activates"| Insulin_Signaling["Insulin Signaling"]
    style Insulin_Signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (121)

Target	Relation	Type	Str
Insulin Resistance	involved_in	phenotype	0.90
Alzheimer's Disease	involved_in	disease	0.90
Parkinson's Disease	involved_in	disease	0.90
Cognitive Function	regulates	phenotype	0.90
Mitochondrial Dysfunction	regulates	process	0.90
Glucose Disposal	regulates	phenotype	0.90
NEURODEGENERATION	protects_against	process	0.88
TAU	regulates	protein	0.85
Insulin Resistance	causes	phenotype	0.80
Tau Hyperphosphorylation	inhibits	process	0.80
Autophagy	regulates	process	0.80
Retinal Ganglion Cell Neuroprotection	involved_in	mechanism	0.80
Retinal Ganglion Cell	modulates	cell_type	0.75
Cholesterol	interacts_with	pathway	0.55
Glycolysis	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Synaptic Plasticity	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
INSULIN	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
INSULIN	associated_with	concept	0.50
Proteins	associated_with	protein	0.50
AXON	protects_against	concept	0.50
INSULIN	protects_against	concept	0.50
Neuroprotection	protects_against	process	0.50
Pi3K/Akt	activates	pathway	0.50
disease	activates	disease	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
Pi3K/Akt	inhibits	pathway	0.50
INSULIN	inhibits	concept	0.50
PI3K/AKT/mTOR	inhibits	pathway	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50
INSULIN	regulates	concept	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
GLUCOSE METABOLISM	activates	concept	0.50
IRS1	activates	concept	0.50
disease	inhibits	disease	0.50
NEURONS	inhibits	concept	0.50
ALZHEIMER'S	inhibits	concept	0.50
ALZHEIMER'S	activates	concept	0.50
CHRONIC INFLAMMATION	inhibits	concept	0.50
ENDOTHELIAL	activates	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
Nephropathy	associated_with	disease	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
IRS1	associated_with	concept	0.50
GLUTAMATE	associated_with	concept	0.50

Incoming (633)

Source	Relation	Type	Str
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
PI3K	activates	gene	1.00
INSULIN RESISTANCE	activates	gene	1.00
Aging	activates	disease	1.00
Insulin Resistance	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
GLP-1	associated_with	protein	0.95
GLP-1	promotes	protein	0.95
AKT	component_of	protein	0.90
MTOR	component_of	protein	0.90
GLP-1R	activates	receptor	0.90
MTOR	activates	gene	0.90
AKT	activates	gene	0.90
GENES	activates	gene	0.90
Alzheimer	activates	disease	0.90
Aging	therapeutic_target	disease	0.90
AGING	activates	gene	0.90
Glp-1 Receptor Agonists	associated_with	drug	0.87
Obesity	activates	disease	0.80
Diabetes	activates	disease	0.80
Diabetes	contributes_to	disease	0.80
Neurodegeneration	contributes_to	disease	0.80
Cardiovascular	activates	disease	0.80
Diabetes	therapeutic_target	disease	0.80
INSULIN RESISTANCE	therapeutic_target	gene	0.80
OXIDATIVE STRESS	contributes_to	gene	0.80
AKT	regulates	gene	0.80
NEURODEGENERATION	contributes_to	gene	0.80
INSULIN RESISTANCE	contributes_to	gene	0.80
Insulin Resistance	contributes_to	disease	0.80
TAU	activates	gene	0.80
APOPTOSIS	activates	gene	0.80
ALZHEIMER	activates	gene	0.80
ALZHEIMER'S DISEASE	activates	gene	0.80
ALZHEIMER	associated_with	gene	0.80
AMYLOID	activates	gene	0.80
Alzheimer	associated_with	disease	0.80
Neurodegeneration	activates	disease	0.75
Alzheimer	contributes_to	disease	0.70
Inflammation	contributes_to	disease	0.70
PI3K	therapeutic_target	gene	0.70
AKT	therapeutic_target	gene	0.70
PI3K	associated_with	gene	0.70
AKT	associated_with	gene	0.70
Inflammation	therapeutic_target	disease	0.70
Alzheimer	therapeutic_target	disease	0.70
MTORC1	activates	gene	0.70
MTOR	inhibits	gene	0.70
AMPK	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Insulin Signaling

Understanding Entity Pages

Summary

Wiki Pages (21)

Brain Insulin Signaling

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