Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNAQ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GNAQ is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Als, Cancer, Carcinoma. Connected to 23 entities in the SciDEX knowledge graph.
| Gene Symbol | GNAQ |
| Full Name | G Protein Subunit Alpha Q |
| Chromosome | 9q21.13 |
| Function | The GNAQ protein is involved in transmitting signals from G protein-coupled receptors (GPCRs) on the cell surface to intracellular effector proteins. |
| Primary Expression | the central nervous system and is particularly important for neuronal signaling, synaptic plasticity, and cellular responses to neurotransmitters and |
| Pathways | Akt, Pi3K |
| UniProt ID | [P50148](https://www.uniprot.org/uniprot/P50148) |
| Ensembl ID | ENSG00000156052 |
| GeneCards | GNAQ |
| Human Protein Atlas | GNAQ |
| Calcium signaling | Modulation of neuronal excitability and synaptic transmission |
| PKC activation | Regulation of ion channel function and gene expression |
| Cytoskeletal dynamics | Control of neuronal morphology and plasticity |
| Associated Diseases | neurodegeneration |
| Interactions | STX17, GNA11, AKT, BRAF, PI3K, ERK1 |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GNAQ["<b>GNAQ</b>"]
Als{"Als"}
GNAQ -->|"activates"| Als
Ms{"Ms"}
GNAQ -->|"activates"| Ms
GNAQ -->|"therapeutic target"| Ms
Cancer{"Cancer"}
GNAQ -->|"therapeutic target"| Cancer
Carcinoma{"Carcinoma"}
GNAQ -->|"therapeutic target"| Carcinoma
STX17["STX17"]
GNAQ -->|"activates"| STX17
GNA11["GNA11"]
GNAQ -->|"activates"| GNA11
AKT["AKT"]
GNAQ -->|"activates"| AKT
Akt(["Akt"])
GNAQ -->|"activates"| Akt
Pi3K(["Pi3K"])
GNAQ -->|"activates"| Pi3K
Mapk(["Mapk"])
GNAQ -->|"associated with"| Mapk
neurodegeneration["neurodegeneration"]
GNAQ -->|"implicated in"| neurodegeneration
BRAF["BRAF"]
BRAF -->|"activates"| GNAQ
KRAS["KRAS"]
KRAS -->|"activates"| GNAQ
ERK["ERK"]
ERK -->|"activates"| GNAQ
PI3K["PI3K"]
PI3K -->|"activates"| GNAQ
GENES["GENES"]
GENES -->|"activates"| GNAQ
ERK1["ERK1"]
ERK1 -->|"activates"| GNAQ
FYN["FYN"]
FYN -->|"associated with"| GNAQ
MAPK3["MAPK3"]
MAPK3 -->|"associated with"| GNAQ
PAK1["PAK1"]
PAK1 -->|"associated with"| GNAQ
CDK2["CDK2"]
CDK2 -->|"associated with"| GNAQ
MAP1LC3B["MAP1LC3B"]
MAP1LC3B -->|"associated with"| GNAQ
style GNAQ fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| STX17 | activates | gene | 0.60 |
| GNA11 | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| Akt | activates | pathway | 0.60 |
| Pi3K | activates | pathway | 0.60 |
| Mapk | associated_with | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||