gene

GNAQ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNAQ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections
0Hypotheses
0Analyses
11Outgoing
11Incoming

Summary

GNAQ is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Als, Cancer, Carcinoma. Connected to 23 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGNAQ
Full NameG Protein Subunit Alpha Q
Chromosome9q21.13
FunctionThe GNAQ protein is involved in transmitting signals from G protein-coupled receptors (GPCRs) on the cell surface to intracellular effector proteins.
Primary Expressionthe central nervous system and is particularly important for neuronal signaling, synaptic plasticity, and cellular responses to neurotransmitters and
PathwaysAkt, Pi3K
UniProt ID[P50148](https://www.uniprot.org/uniprot/P50148)
Ensembl IDENSG00000156052
GeneCardsGNAQ
Human Protein AtlasGNAQ
Calcium signalingModulation of neuronal excitability and synaptic transmission
PKC activationRegulation of ion channel function and gene expression
Cytoskeletal dynamicsControl of neuronal morphology and plasticity
Associated Diseasesneurodegeneration
InteractionsSTX17, GNA11, AKT, BRAF, PI3K, ERK1
KG Connections22 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

GNAQ Gene

gene · 1049 words

CHRM3 Gene

gene · 2728 words

chrm1

gene · 2238 words

G Proteins

mechanism · 1607 words

GALR2 Gene

gene · 1271 words

PLCB4 — Phospholipase C Beta 4

gene · 1257 words

Pathway Diagram

graph TD
    GNAQ["<b>GNAQ</b>"]
    Als{"Als"}
    GNAQ -->|"activates"| Als
    Ms{"Ms"}
    GNAQ -->|"activates"| Ms
    GNAQ -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    GNAQ -->|"therapeutic target"| Cancer
    Carcinoma{"Carcinoma"}
    GNAQ -->|"therapeutic target"| Carcinoma
    STX17["STX17"]
    GNAQ -->|"activates"| STX17
    GNA11["GNA11"]
    GNAQ -->|"activates"| GNA11
    AKT["AKT"]
    GNAQ -->|"activates"| AKT
    Akt(["Akt"])
    GNAQ -->|"activates"| Akt
    Pi3K(["Pi3K"])
    GNAQ -->|"activates"| Pi3K
    Mapk(["Mapk"])
    GNAQ -->|"associated with"| Mapk
    neurodegeneration["neurodegeneration"]
    GNAQ -->|"implicated in"| neurodegeneration
    BRAF["BRAF"]
    BRAF -->|"activates"| GNAQ
    KRAS["KRAS"]
    KRAS -->|"activates"| GNAQ
    ERK["ERK"]
    ERK -->|"activates"| GNAQ
    PI3K["PI3K"]
    PI3K -->|"activates"| GNAQ
    GENES["GENES"]
    GENES -->|"activates"| GNAQ
    ERK1["ERK1"]
    ERK1 -->|"activates"| GNAQ
    FYN["FYN"]
    FYN -->|"associated with"| GNAQ
    MAPK3["MAPK3"]
    MAPK3 -->|"associated with"| GNAQ
    PAK1["PAK1"]
    PAK1 -->|"associated with"| GNAQ
    CDK2["CDK2"]
    CDK2 -->|"associated with"| GNAQ
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"associated with"| GNAQ
    style GNAQ fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

TargetRelationTypeStr
Alsactivatesdisease0.65
Msactivatesdisease0.65
Mstherapeutic_targetdisease0.65
Cancertherapeutic_targetdisease0.65
Carcinomatherapeutic_targetdisease0.65

Incoming (11)

SourceRelationTypeStr
BRAFactivatesgene0.60
PI3Kactivatesgene0.60
ERK1activatesgene0.60
FYNassociated_withgene0.60
MAPK3associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found