protein

GRM5PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRM5PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Mglur5 Protein — Glutamate Metabotropic Receptor 5 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	GRM5PROTEIN
Full Name	Metabotropic Glutamate Receptor 5
Protein Family	Class C GPCR, mGluR family
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	cerebellum (unlike mGluR1)
Molecular Weight	~143 kDa (1211 aa)
Amino Acids	1211 aa
UniProt ID	P41594
GeneCards	GRM5PROTEIN
Human Protein Atlas	GRM5PROTEIN
Large VFT Domain	Binds glutamate and related ligands
Cysteine-Rich Domain	Links extracellular and transmembrane domains
7-TM Domain	Seven transmembrane helices (TM1-TM7)
C-terminal Tail	Long intracellular tail with multiple interaction motifs
Associated Diseases	Alzheimer, Autism, Bipolar, Cancer, Inflammation, Ms
Interactions	CACNA1B, CACNA1H, CDK5R2, DRD1, DRD2, FGF13
SciDEX Hypotheses	Metabotropic Glutamate Receptor-Based Sleep Stabil
KG Connections	118 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GRM5PROTEIN — AlphaFold P41594 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mGluR5 Protein — Glutamate Metabotropic Receptor 5

protein · 866 words

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Pathway Diagram

graph TD
    GRM5PROTEIN["GRM5PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GRM5PROTEIN -->|"implicated_in"| neurodegeneration
    style GRM5PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRM5PROTEIN in their description or question text

No additional research found