| Gene Symbol | GRM5PROTEIN |
| Full Name | Metabotropic Glutamate Receptor 5 |
| Protein Family | Class C GPCR, mGluR family |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | cerebellum (unlike mGluR1) |
| Molecular Weight | ~143 kDa (1211 aa) |
| Amino Acids | 1211 aa |
| UniProt ID | P41594 |
| GeneCards | GRM5PROTEIN |
| Human Protein Atlas | GRM5PROTEIN |
| Large VFT Domain | Binds glutamate and related ligands |
| Cysteine-Rich Domain | Links extracellular and transmembrane domains |
| 7-TM Domain | Seven transmembrane helices (TM1-TM7) |
| C-terminal Tail | Long intracellular tail with multiple interaction motifs |
| Associated Diseases | Alzheimer, Autism, Bipolar, Cancer, Inflammation, Ms |
| Interactions | CACNA1B, CACNA1H, CDK5R2, DRD1, DRD2, FGF13 |
| SciDEX Hypotheses | Metabotropic Glutamate Receptor-Based Sleep Stabil |
| KG Connections | 118 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!