gene

FGF13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

0Analyses

39Outgoing

23Incoming

Summary

Gene profile: FGF13 - neuronal FGF family member involved in brain development, synaptic function, and implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions through neurotrophic signaling, neuroprotection, and excitotoxicity mechanisms.

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🧬 Gene Info

Gene Symbol	FGF13
Full Name	Fibroblast Growth Factor 13
Aliases	Gene profile: FGF13
Chromosome	Xq26.3
Protein Type	Channel
Function	is a member of the FGF family that is predominantly expressed in neuronal tissues, distinguishing it from many other FGFs with broader expression patterns.
Primary Expression	neuronal tissues, distinguishing it from many other FGFs with broader expression patterns
Gene Type	Protein coding
Pathways	Calcium Signaling
UniProt ID	P15532
NCBI Gene ID	2253
GeneCards	FGF13
Human Protein Atlas	FGF13
Alternative Names	FGF13, FHF-1, FGF13A
Mechanism	Effect
Associated Diseases	Inflammation
Interactions	CDK5R2, SLC17A7, GRM5, ISG15, SCN2B, SCN8A
KG Connections	62 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FGF13 — AlphaFold P15532 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FGF13["<b>FGF13</b>"]
    Inflammation["Inflammation"]
    FGF13 -->|"associated with"| Inflammation
    SCN2B["SCN2B"]
    FGF13 -->|"therapeutic target"| SCN2B
    CDK5R2["CDK5R2"]
    FGF13 -->|"therapeutic target"| CDK5R2
    ISG15["ISG15"]
    FGF13 -->|"therapeutic target"| ISG15
    INFLAMMATION["INFLAMMATION"]
    FGF13 -->|"associated with"| INFLAMMATION
    SLC17A7["SLC17A7"]
    FGF13 -->|"associated with"| SLC17A7
    AND["AND"]
    FGF13 -->|"associated with"| AND
    CDK5R2["CDK5R2"]
    FGF13 -->|"associated with"| CDK5R2
    HUB_GENES["HUB GENES"]
    FGF13 -->|"associated with"| HUB_GENES
    GRM5["GRM5"]
    FGF13 -->|"associated with"| GRM5
    SLC17A7["SLC17A7"]
    SLC17A7 -->|"therapeutic target"| FGF13
    GRM5["GRM5"]
    GRM5 -->|"therapeutic target"| FGF13
    SCN8A["SCN8A"]
    SCN8A -->|"therapeutic target"| FGF13
    STAT1["STAT1"]
    STAT1 -->|"therapeutic target"| FGF13
    SCN2B["SCN2B"]
    SCN2B -->|"associated with"| FGF13
    STAT1["STAT1"]
    STAT1 -->|"associated with"| FGF13
    GENES["GENES"]
    GENES -->|"associated with"| FGF13
    ISG15["ISG15"]
    ISG15 -->|"associated with"| FGF13
    SCN8A["SCN8A"]
    SCN8A -->|"associated with"| FGF13
    CDK5R2["CDK5R2"]
    FGF13 -->|"interacts with"| CDK5R2
    SLC17A7["SLC17A7"]
    FGF13 -->|"interacts with"| SLC17A7
    Genes["Genes"]
    FGF13 -->|"interacts with"| Genes
    ISG15["ISG15"]
    ISG15 -->|"interacts with"| FGF13
    STAT1["STAT1"]
    STAT1 -->|"interacts with"| FGF13
    SCN2B["SCN2B"]
    SCN2B -->|"interacts with"| FGF13
    SCN8A["SCN8A"]
    SCN8A -->|"interacts with"| FGF13
    GRM5["GRM5"]
    GRM5 -->|"interacts with"| FGF13
    GRM5["GRM5"]
    GRM5 -->|"associated with"| FGF13
    neurodegeneration["neurodegeneration"]
    FGF13 -->|"implicated in"| neurodegeneration

Outgoing (39)

Target	Relation	Type	Str
Encephalitis	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
SCN2B	therapeutic_target	gene	0.60
CDK5R2	therapeutic_target	gene	0.60
ISG15	therapeutic_target	gene	0.60
SLC17A7	associated_with	gene	0.60
CDK5R2	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
SCN8A	therapeutic_target	gene	0.60
SLC17A7	therapeutic_target	gene	0.60
GRM5	therapeutic_target	gene	0.60
Cdk5	therapeutic_target	protein	0.60
GRM5	interacts_with	gene	0.60
ISG15	interacts_with	gene	0.60
SCN2B	interacts_with	gene	0.60
SCN8A	interacts_with	gene	0.60
STAT1	interacts_with	gene	0.60
GRM5	targets	gene	0.60
ISG15	targets	gene	0.60
SCN2B	targets	gene	0.60
SCN8A	targets	gene	0.60
SLC17A7	targets	gene	0.60
STAT1	targets	gene	0.60
ISG15	associated_with	gene	0.60
SCN2B	associated_with	gene	0.60
SCN8A	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AND	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
Interferon	therapeutic_target	protein	0.60
Interferon Signaling	therapeutic_target	pathway	0.60
App	therapeutic_target	protein	0.60
Fgf	therapeutic_target	protein	0.60
Calcium Signaling	regulates	pathway	0.60
Fibroblast	regulates	cell_type	0.60
Fgf	inhibits	protein	0.60
CDK5R2	interacts_with	protein	0.50
SLC17A7	interacts_with	protein	0.50

Incoming (23)

Source	Relation	Type	Str
SLC17A7	therapeutic_target	gene	0.60
GRM5	therapeutic_target	gene	0.60
SCN8A	therapeutic_target	gene	0.60
STAT1	therapeutic_target	gene	0.60
SCN2B	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
ISG15	associated_with	gene	0.60
SCN8A	associated_with	gene	0.60
CDK5R2	therapeutic_target	gene	0.60
SCN2B	therapeutic_target	gene	0.60
ISG15	therapeutic_target	gene	0.60
CAV1	activates	gene	0.60
CDK5R2	interacts_with	gene	0.60
CDK5R2	targets	gene	0.60
CDK5R2	associated_with	gene	0.60
GENES	associated_with	gene	0.60
MICROTUBULES	activates	gene	0.60
ISG15	interacts_with	gene	0.50
STAT1	interacts_with	gene	0.50
SCN2B	interacts_with	gene	0.50
SCN8A	interacts_with	gene	0.50
GRM5	interacts_with	gene	0.50
GRM5	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FGF13

Understanding Entity Pages

Summary

Wiki Pages (12)

FGF13 — Fibroblast Growth Factor 13

Fibroblast Growth Factor Signaling in Neurodegeneration

GRM5 Gene - Metabotropic Glutamate Receptor 5

FGF13-MTCH2 Neuroprotection in Parkinson's Disease

SCN7A Gene

Rostral Interstitial Nucleus of MLF (riMLF) Neurons

mGluR5 (Metabotropic Glutamate Receptor 5)

FGF14 — Fibroblast Growth Factor 14

FGF22 — Fibroblast Growth Factor 22

SCN2B Gene - Sodium Channel Beta Subunit