GAMMA-SECRETASE

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAMMA-SECRETASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    GAMMA_SECRETASE["GAMMA-SECRETASE"]
    GAMMA_SECRETASE -->|"interacts"| HSPG2["HSPG2"]
    GAMMA_SECRETASE -->|"activates"| ALZHEIMER["ALZHEIMER"]
    GAMMA_SECRETASE -->|"activates"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    GAMMA_SECRETASE -->|"activates"| disease["disease"]
    GAMMA_SECRETASE -->|"activates"| ALZHEIMER_S["ALZHEIMER'S"]
    GAMMA_SECRETASE -->|"inhibits"| NEURONS["NEURONS"]
    PSEN1["PSEN1"] -->|"involved_in"| GAMMA_SECRETASE
    APH1B["APH1B"] -->|"interacts"| GAMMA_SECRETASE
    PEN2["PEN2"] -->|"interacts"| GAMMA_SECRETASE
    NCSTN["NCSTN"] -->|"interacts"| GAMMA_SECRETASE
    PSEN2["PSEN2"] -->|"interacts"| GAMMA_SECRETASE
    GSK3B["GSK3B"] -->|"regulates"| GAMMA_SECRETASE
    LRP1["LRP1"] -->|"regulates"| GAMMA_SECRETASE