PEN2

Understanding Entity Pages

This page aggregates everything SciDEX knows about PEN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PEN2 (Presenilin Enhancer 2) is a component of the gamma-secretase complex that cleaves APP to generate amyloid-beta

View on Wiki →

graph TD
    PEN2["<b>PEN2</b>"]
    Alzheimer{"Alzheimer"}
    PEN2 -->|"interacts with"| Alzheimer
    Tumor{"Tumor"}
    PEN2 -->|"interacts with"| Tumor
    Als{"Als"}
    PEN2 -->|"interacts with"| Als
    ALS{"ALS"}
    PEN2 -->|"interacts with"| ALS
    PSEN1["PSEN1"]
    PEN2 -->|"interacts with"| PSEN1
    DAPK1["DAPK1"]
    PEN2 -->|"interacts with"| DAPK1
    HSPG2["HSPG2"]
    PEN2 -->|"interacts with"| HSPG2
    IL1B["IL1B"]
    PEN2 -->|"interacts with"| IL1B
    APP["APP"]
    PEN2 -->|"interacts with"| APP
    EIF2AK2["EIF2AK2"]
    PEN2 -->|"interacts with"| EIF2AK2
    Cholesterol(["Cholesterol"])
    PEN2 -->|"interacts with"| Cholesterol
    Apoptosis(["Apoptosis"])
    PEN2 -->|"interacts with"| Apoptosis
    NCSTN["NCSTN"]
    NCSTN -->|"interacts with"| PEN2
    FAS["FAS"]
    FAS -->|"interacts with"| PEN2
    TNF["TNF"]
    TNF -->|"interacts with"| PEN2
    LMNA["LMNA"]
    LMNA -->|"interacts with"| PEN2
    APH1B["APH1B"]
    APH1B -->|"interacts with"| PEN2
    APOE["APOE"]
    APOE -->|"interacts with"| PEN2
    IL6["IL6"]
    IL6 -->|"interacts with"| PEN2
    SREBF1["SREBF1"]
    SREBF1 -->|"interacts with"| PEN2
    PSEN2["PSEN2"]
    PSEN2 -->|"interacts with"| PEN2
    A2M["A2M"]
    A2M -->|"interacts with"| PEN2
    DHCR24["DHCR24"]
    DHCR24 -->|"interacts with"| PEN2
    HMGCR["HMGCR"]
    HMGCR -->|"interacts with"| PEN2
    style PEN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0