NCSTN

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCSTN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Nicastrin - component of the gamma-secretase complex

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graph TD
    NCSTN["<b>NCSTN</b>"]
    Alzheimer{"Alzheimer"}
    NCSTN -->|"interacts with"| Alzheimer
    Tumor{"Tumor"}
    NCSTN -->|"interacts with"| Tumor
    Als{"Als"}
    NCSTN -->|"interacts with"| Als
    ALS{"ALS"}
    NCSTN -->|"interacts with"| ALS
    FAS["FAS"]
    NCSTN -->|"interacts with"| FAS
    TNF["TNF"]
    NCSTN -->|"interacts with"| TNF
    LMNA["LMNA"]
    NCSTN -->|"interacts with"| LMNA
    APH1B["APH1B"]
    NCSTN -->|"interacts with"| APH1B
    APOE["APOE"]
    NCSTN -->|"interacts with"| APOE
    IL6["IL6"]
    NCSTN -->|"interacts with"| IL6
    SREBF1["SREBF1"]
    NCSTN -->|"interacts with"| SREBF1
    PSEN2["PSEN2"]
    NCSTN -->|"interacts with"| PSEN2
    DHCR24["DHCR24"]
    DHCR24 -->|"interacts with"| NCSTN
    EIF2AK2["EIF2AK2"]
    EIF2AK2 -->|"interacts with"| NCSTN
    LMNA -->|"interacts with"| NCSTN
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"interacts with"| NCSTN
    IL1B["IL1B"]
    IL1B -->|"interacts with"| NCSTN
    DAPK1["DAPK1"]
    DAPK1 -->|"interacts with"| NCSTN
    HMGCR["HMGCR"]
    HMGCR -->|"interacts with"| NCSTN
    GENES["GENES"]
    GENES -->|"interacts with"| NCSTN
    PARP1["PARP1"]
    PARP1 -->|"interacts with"| NCSTN
    TNF -->|"interacts with"| NCSTN
    HSPG2["HSPG2"]
    HSPG2 -->|"interacts with"| NCSTN
    A2M["A2M"]
    A2M -->|"interacts with"| NCSTN
    style NCSTN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0