Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HARS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HARS is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Ataxia, Ms. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | HARS1 |
| Full Name | Histidyl-tRNA Synthetase 1 |
| Aliases | HARS |
| Chromosome | 5q31.3 |
| Function | HARS1 encodes histidyl-tRNA synthetase 1 (HisRS), an essential enzyme in protein synthesis that catalyzes the attachment of histidine to its cognate tRNA (tRNA<sup>His</sup>) 1. |
| Molecular Weight | 56 kDa |
| Amino Acids | 509 aa |
| Exons | 19 |
| GeneCards | HARS1 |
| Human Protein Atlas | HARS1 |
| Associated Diseases | Ataxia, Ms |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HARS["<b>HARS</b>"]
Ms{"Ms"}
HARS -->|"associated with"| Ms
Ataxia{"Ataxia"}
HARS -->|"associated with"| Ataxia
ATM["ATM"]
HARS -->|"associated with"| ATM
CLPP["CLPP"]
HARS -->|"associated with"| CLPP
SETX["SETX"]
HARS -->|"associated with"| SETX
LARS2["LARS2"]
HARS -->|"associated with"| LARS2
POLG["POLG"]
HARS -->|"associated with"| POLG
SIL1["SIL1"]
HARS -->|"associated with"| SIL1
STUB1["STUB1"]
HARS -->|"associated with"| STUB1
FMR1["FMR1"]
HARS -->|"associated with"| FMR1
TWNK["TWNK"]
HARS -->|"associated with"| TWNK
PNPLA6["PNPLA6"]
HARS -->|"associated with"| PNPLA6
WFS1["WFS1"]
WFS1 -->|"associated with"| HARS
style HARS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| ATM | associated_with | gene | 0.60 |
| CLPP | associated_with | gene | 0.60 |
| SETX | associated_with | gene | 0.60 |
| LARS2 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| SIL1 | associated_with | gene | 0.60 |
| STUB1 | associated_with | gene | 0.60 |
| FMR1 | associated_with | gene | 0.60 |
| TWNK | associated_with | gene | 0.60 |
| PNPLA6 | associated_with | gene | 0.60 |
| WFS1 | associated_with | gene | 0.60 |
| RNF216 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||