gene

HARS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HARS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections
0Hypotheses
0Analyses
14Outgoing
8Incoming

Summary

HARS is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Ataxia, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolHARS1
Full NameHistidyl-tRNA Synthetase 1
AliasesHARS
Chromosome5q31.3
FunctionHARS1 encodes histidyl-tRNA synthetase 1 (HisRS), an essential enzyme in protein synthesis that catalyzes the attachment of histidine to its cognate tRNA (tRNA<sup>His</sup>) 1.
Molecular Weight56 kDa
Amino Acids509 aa
Exons19
GeneCardsHARS1
Human Protein AtlasHARS1
Associated DiseasesAtaxia, Ms
KG Connections22 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

HARS1 — Histidyl-tRNA Synthetase 1

gene · 1686 words

Autophagy Mechanisms

mechanism · 4866 words

amyloid-beta-metalloproteinases

mechanism · 4656 words

AI and Machine Learning in Neurodegeneration

mechanism · 4541 words

protective-strategies-cbs-psp

therapeutic · 4501 words

Section 152: Advanced Robotics and Assistive Devices in CBS/PSP

therapeutic · 4341 words

Pathway Diagram

graph TD
    HARS["<b>HARS</b>"]
    Ms{"Ms"}
    HARS -->|"associated with"| Ms
    Ataxia{"Ataxia"}
    HARS -->|"associated with"| Ataxia
    ATM["ATM"]
    HARS -->|"associated with"| ATM
    CLPP["CLPP"]
    HARS -->|"associated with"| CLPP
    SETX["SETX"]
    HARS -->|"associated with"| SETX
    LARS2["LARS2"]
    HARS -->|"associated with"| LARS2
    POLG["POLG"]
    HARS -->|"associated with"| POLG
    SIL1["SIL1"]
    HARS -->|"associated with"| SIL1
    STUB1["STUB1"]
    HARS -->|"associated with"| STUB1
    FMR1["FMR1"]
    HARS -->|"associated with"| FMR1
    TWNK["TWNK"]
    HARS -->|"associated with"| TWNK
    PNPLA6["PNPLA6"]
    HARS -->|"associated with"| PNPLA6
    WFS1["WFS1"]
    WFS1 -->|"associated with"| HARS
    style HARS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

TargetRelationTypeStr
Msassociated_withdisease0.65
Ataxiaassociated_withdisease0.65
ATMassociated_withgene0.60
CLPPassociated_withgene0.60
SETXassociated_withgene0.60

Incoming (8)

SourceRelationTypeStr
WFS1associated_withgene0.60
CLPPassociated_withgene0.60
ATMassociated_withgene0.60
PNPLA6associated_withgene0.60
POLGassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found