gene

TWNK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TWNK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections
0Hypotheses
0Analyses
13Outgoing
28Incoming

Summary

TWNK is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Ataxia, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolTWNK
AliasesPEO1
Chromosome10q24.31
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight77 kDa
Amino Acids684 aa
UniProt IDQ96QR1
Ensembl IDENSG00000107815
OMIM604367
GeneCardsTWNK
Human Protein AtlasTWNK
Gene NameTwinkle Mitochondrial DNA Helicase
Also Known AsPEO1, TWNK
Associated DiseasesAtaxia, Ms
KG Connections41 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: TWNK — AlphaFold Q96QR1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

TWNK Gene

gene · 759 words

Alpers-Huttenlocher Syndrome

disease · 3022 words

POLG — DNA Polymerase Subunit Gamma

gene · 2250 words

SUCLA2 Gene

gene · 2080 words

RRM2B Gene

gene · 2035 words

HARS1 — Histidyl-tRNA Synthetase 1

gene · 1686 words

Pathway Diagram

graph TD
    TWNK["<b>TWNK</b>"]
    Ms{"Ms"}
    TWNK -->|"associated with"| Ms
    Ataxia{"Ataxia"}
    TWNK -->|"associated with"| Ataxia
    PNPLA6["PNPLA6"]
    TWNK -->|"associated with"| PNPLA6
    neurodegeneration["neurodegeneration"]
    TWNK -->|"implicated in"| neurodegeneration
    WFS1["WFS1"]
    WFS1 -->|"associated with"| TWNK
    HARS["HARS"]
    HARS -->|"associated with"| TWNK
    ATM["ATM"]
    ATM -->|"associated with"| TWNK
    CLPP["CLPP"]
    CLPP -->|"associated with"| TWNK
    SETX["SETX"]
    SETX -->|"associated with"| TWNK
    LARS2["LARS2"]
    LARS2 -->|"associated with"| TWNK
    POLG["POLG"]
    POLG -->|"associated with"| TWNK
    SIL1["SIL1"]
    SIL1 -->|"associated with"| TWNK
    STUB1["STUB1"]
    STUB1 -->|"associated with"| TWNK
    FMR1["FMR1"]
    FMR1 -->|"associated with"| TWNK
    style TWNK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

TargetRelationTypeStr
Msassociated_withdisease0.65
Ataxiaassociated_withdisease0.65
PNPLA6associated_withgene0.60
MPV17associated_withgene0.60
DGUOKassociated_withgene0.60

Incoming (28)

SourceRelationTypeStr
WFS1associated_withgene0.60
HARSassociated_withgene0.60
ATMassociated_withgene0.60
CLPPassociated_withgene0.60
SETXassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found