Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TWNK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TWNK is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Ataxia, Ms. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | TWNK |
| Aliases | PEO1 |
| Chromosome | 10q24.31 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 77 kDa |
| Amino Acids | 684 aa |
| UniProt ID | Q96QR1 |
| Ensembl ID | ENSG00000107815 |
| OMIM | 604367 |
| GeneCards | TWNK |
| Human Protein Atlas | TWNK |
| Gene Name | Twinkle Mitochondrial DNA Helicase |
| Also Known As | PEO1, TWNK |
| Associated Diseases | Ataxia, Ms |
| KG Connections | 41 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TWNK["<b>TWNK</b>"]
Ms{"Ms"}
TWNK -->|"associated with"| Ms
Ataxia{"Ataxia"}
TWNK -->|"associated with"| Ataxia
PNPLA6["PNPLA6"]
TWNK -->|"associated with"| PNPLA6
neurodegeneration["neurodegeneration"]
TWNK -->|"implicated in"| neurodegeneration
WFS1["WFS1"]
WFS1 -->|"associated with"| TWNK
HARS["HARS"]
HARS -->|"associated with"| TWNK
ATM["ATM"]
ATM -->|"associated with"| TWNK
CLPP["CLPP"]
CLPP -->|"associated with"| TWNK
SETX["SETX"]
SETX -->|"associated with"| TWNK
LARS2["LARS2"]
LARS2 -->|"associated with"| TWNK
POLG["POLG"]
POLG -->|"associated with"| TWNK
SIL1["SIL1"]
SIL1 -->|"associated with"| TWNK
STUB1["STUB1"]
STUB1 -->|"associated with"| TWNK
FMR1["FMR1"]
FMR1 -->|"associated with"| TWNK
style TWNK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| PNPLA6 | associated_with | gene | 0.60 |
| MPV17 | associated_with | gene | 0.60 |
| DGUOK | associated_with | gene | 0.60 |
| LARS2 | associated_with | gene | 0.60 |
| SIL1 | associated_with | gene | 0.60 |
| HARS | associated_with | gene | 0.60 |
| STUB1 | associated_with | gene | 0.60 |
| WFS1 | associated_with | gene | 0.60 |
| SETX | associated_with | gene | 0.60 |
| FMR1 | associated_with | gene | 0.60 |
| RNF216 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| WFS1 | associated_with | gene | 0.60 |
| HARS | associated_with | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| CLPP | associated_with | gene | 0.60 |
| SETX | associated_with | gene | 0.60 |
| LARS2 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| SIL1 | associated_with | gene | 0.60 |
| STUB1 | associated_with | gene | 0.60 |
| FMR1 | associated_with | gene | 0.60 |
| POLG2 | associated_with | gene | 0.60 |
| SLC25A4 | associated_with | gene | 0.60 |
| MFN2 | associated_with | gene | 0.60 |
| TYMP | associated_with | gene | 0.60 |
| RRM2B | associated_with | gene | 0.60 |
| TK2 | associated_with | gene | 0.60 |
| SUCLA2 | associated_with | gene | 0.60 |
| SUCLG1 | associated_with | gene | 0.60 |
| TFAM | associated_with | gene | 0.60 |
| RNASEH1 | associated_with | gene | 0.60 |
| OPA1 | associated_with | gene | 0.60 |
| PNPLA6 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||