gene 1,686 words KG: HARS 2026-03-27
kind:genesection:genesstate:published
Contents

HARS1 — Histidyl-tRNA Synthetase 1

🧬 Gene Info
Gene SymbolHARS1
Full NameHistidyl-tRNA Synthetase 1
AliasesHARS
Chromosome5q31.3
FunctionHARS1 encodes histidyl-tRNA synthetase 1 (HisRS), an essential enzyme in protein synthesis that catalyzes the attachment of histidine to its cognate tRNA (tRNA<sup>His</sup>) 1.
Molecular Weight56 kDa
Amino Acids509 aa
Exons19
GeneCardsHARS1
Human Protein AtlasHARS1
Associated DiseasesAtaxia, Ms
KG Connections22 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
R-Loop Resolution Enhancement Therapy
Score: 0.43

Related Analyses (3)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (12)

WFS1 — Wolfram Syndrome 1
gene · KG edge: associated_with
TWNK Gene
gene · KG edge: associated_with
STUB1 — CHIP
gene · KG edge: associated_with
SIL1 Gene
gene · KG edge: associated_with
SETX Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

HARS associated_with ATM
HARS associated_with CLPP
HARS associated_with SETX
HARS associated_with LARS2
HARS associated_with POLG
HARS associated_with SIL1
HARS associated_with STUB1
HARS associated_with FMR1
HARS associated_with TWNK
HARS associated_with PNPLA6