POLG

Understanding Entity Pages

This page aggregates everything SciDEX knows about POLG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

POLG is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Aging, Als. Connected to 147 entities in the SciDEX knowledge graph.

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flowchart TD
    POLG["POLG<br/>Mitochondrial DNA<br/>Polymerase gamma"]
    MTDNA["MTDNA<br/>Mitochondrial DNA<br/>Replication"]
    DNA_REP["DNA Repair<br/> and Maintenance"]
    MITO_DYSFUNC["Mitochondrial<br/>Dysfunction"]
    AUTOPHAGY["Autophagy<br/>Pathway"]
    FERROPTOSIS["Ferroptosis<br/>Pathway"]
    ATM["ATM<br/>DNA Damage<br/>Response"]
    STING1["STING1<br/>Innate Immunity<br/>Signaling"]
    SLC7A11["SLC7A11<br/>Cystine/Glutamate<br/>Antiporter"]
    CIRCADIAN["Circadian Rhythm<br/>Regulation"]
    PARKINSON["Parkinson's<br/>Disease"]
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    MS["Multiple<br/>Sclerosis"]
    NEURODEGENERATION["Neurodegeneration<br/>Outcomes"]
    OXIDATIVE["Oxidative Stress<br/> and Cell Death"]

    POLG --|"replicates"|--> MTDNA
    POLG --|"maintains"|--> DNA_REP
    MTDNA --|"dysfunction"|--> MITO_DYSFUNC
    MITO_DYSFUNC --|"triggers"|--> OXIDATIVE
    POLG --|"activates"|--> FERROPTOSIS
    POLG --|"associated with"|--> AUTOPHAGY
    POLG --|"interacts with"|--> ATM
    POLG --|"signals through"|--> STING1
    POLG --|"regulates"|--> SLC7A11
    POLG --|"influences"|--> CIRCADIAN
    OXIDATIVE --|"leads to"|--> PARKINSON
    OXIDATIVE --|"leads to"|--> ALS
    OXIDATIVE --|"leads to"|--> MS
    FERROPTOSIS --|"contributes to"|--> NEURODEGENERATION
    PARKINSON --|"part of"|--> NEURODEGENERATION
    ALS --|"part of"|--> NEURODEGENERATION
    MS --|"part of"|--> NEURODEGENERATION

    style POLG fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style ATM fill:#4a1a6b
    style STING1 fill:#4a1a6b
    style SLC7A11 fill:#4a1a6b
    style CIRCADIAN fill:#4a1a6b
    style FERROPTOSIS fill:#ef5350
    style MITO_DYSFUNC fill:#ef5350
    style OXIDATIVE fill:#ef5350
    style PARKINSON fill:#5d4400
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style NEURODEGENERATION fill:#5d4400