gene

WFS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WFS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections
0Hypotheses
0Analyses
20Outgoing
18Incoming

Summary

WFS1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Ataxia, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolWFS1
Full NameWolframin ER Calcium Channel
AliasesPage for WFS1 Protein
Chromosome4p16.1
FunctionThe WFS1 gene encodes wolframin, a transmembrane protein localized primarily to the endoplasmic reticulum (ER).
Primary ExpressionPancreas, Brain, Heart, Kidney, Eye
Molecular Weight100.3 kDa
Amino Acids890 aa
Pathwayssignaling: - Activates Akt pathway
UniProt IDO76024
NCBI Gene ID7466
Ensembl IDENSG00000109501
OMIM222300
GeneCardsWFS1
Human Protein AtlasWFS1
Associated DiseasesAtaxia, Ms
InteractionsSRPK1
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: WFS1 — AlphaFold O76024 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Parasubiculum

cell · 635 words

LARS2 — Leucyl-tRNA Synthetase 2, Mitochondrial

gene · 2642 words

Wolfram Syndrome

disease · 2454 words

Entorhinal Cortex Layer III Neurons

cell · 2097 words

PNPLA6 Gene — Neuropathy Target Esterase (NTE) in Neurodegeneration

gene · 2026 words

HARS1 — Histidyl-tRNA Synthetase 1

gene · 1686 words

Pathway Diagram

graph TD
    WFS1["<b>WFS1</b>"]
    Ms{"Ms"}
    WFS1 -->|"associated with"| Ms
    Ataxia{"Ataxia"}
    WFS1 -->|"associated with"| Ataxia
    HARS["HARS"]
    WFS1 -->|"associated with"| HARS
    ATM["ATM"]
    WFS1 -->|"associated with"| ATM
    CLPP["CLPP"]
    WFS1 -->|"associated with"| CLPP
    SETX["SETX"]
    WFS1 -->|"associated with"| SETX
    LARS2["LARS2"]
    WFS1 -->|"associated with"| LARS2
    POLG["POLG"]
    WFS1 -->|"associated with"| POLG
    SIL1["SIL1"]
    WFS1 -->|"associated with"| SIL1
    STUB1["STUB1"]
    WFS1 -->|"associated with"| STUB1
    FMR1["FMR1"]
    WFS1 -->|"associated with"| FMR1
    TWNK["TWNK"]
    WFS1 -->|"associated with"| TWNK
    style WFS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

TargetRelationTypeStr
Msassociated_withdisease0.65
Ataxiaassociated_withdisease0.65
Diabetestherapeutic_targetdisease0.65
Alstherapeutic_targetdisease0.65
Neurodegenerationtherapeutic_targetdisease0.65

Incoming (18)

SourceRelationTypeStr
CLPPassociated_withgene0.60
ATMassociated_withgene0.60
PNPLA6associated_withgene0.60
POLGassociated_withgene0.60
TWNKassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found