Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WFS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
WFS1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Ataxia, Ms. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | WFS1 |
| Full Name | Wolframin ER Calcium Channel |
| Aliases | Page for WFS1 Protein |
| Chromosome | 4p16.1 |
| Function | The WFS1 gene encodes wolframin, a transmembrane protein localized primarily to the endoplasmic reticulum (ER). |
| Primary Expression | Pancreas, Brain, Heart, Kidney, Eye |
| Molecular Weight | 100.3 kDa |
| Amino Acids | 890 aa |
| Pathways | signaling: - Activates Akt pathway |
| UniProt ID | O76024 |
| NCBI Gene ID | 7466 |
| Ensembl ID | ENSG00000109501 |
| OMIM | 222300 |
| GeneCards | WFS1 |
| Human Protein Atlas | WFS1 |
| Associated Diseases | Ataxia, Ms |
| Interactions | SRPK1 |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
WFS1["<b>WFS1</b>"]
Ms{"Ms"}
WFS1 -->|"associated with"| Ms
Ataxia{"Ataxia"}
WFS1 -->|"associated with"| Ataxia
HARS["HARS"]
WFS1 -->|"associated with"| HARS
ATM["ATM"]
WFS1 -->|"associated with"| ATM
CLPP["CLPP"]
WFS1 -->|"associated with"| CLPP
SETX["SETX"]
WFS1 -->|"associated with"| SETX
LARS2["LARS2"]
WFS1 -->|"associated with"| LARS2
POLG["POLG"]
WFS1 -->|"associated with"| POLG
SIL1["SIL1"]
WFS1 -->|"associated with"| SIL1
STUB1["STUB1"]
WFS1 -->|"associated with"| STUB1
FMR1["FMR1"]
WFS1 -->|"associated with"| FMR1
TWNK["TWNK"]
WFS1 -->|"associated with"| TWNK
style WFS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| Diabetes | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| HARS | associated_with | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| CLPP | associated_with | gene | 0.60 |
| SETX | associated_with | gene | 0.60 |
| LARS2 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| SIL1 | associated_with | gene | 0.60 |
| STUB1 | associated_with | gene | 0.60 |
| FMR1 | associated_with | gene | 0.60 |
| TWNK | associated_with | gene | 0.60 |
| PNPLA6 | associated_with | gene | 0.60 |
| Oxidative Stress | therapeutic_target | pathway | 0.60 |
| Apoptosis | protects_against | pathway | 0.60 |
| Mitochondrial Function | therapeutic_target | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CLPP | associated_with | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| PNPLA6 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| TWNK | associated_with | gene | 0.60 |
| LARS2 | associated_with | gene | 0.60 |
| SIL1 | associated_with | gene | 0.60 |
| HARS | associated_with | gene | 0.60 |
| STUB1 | associated_with | gene | 0.60 |
| SRPK1 | interacts_with | gene | 0.60 |
| SRPK1 | associated_with | gene | 0.60 |
| APOPTOSIS | protects_against | gene | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
| NEURODEGENERATION | therapeutic_target | gene | 0.60 |
| DIABETES MELLITUS | therapeutic_target | gene | 0.60 |
| RNF216 | associated_with | gene | 0.60 |
| HLA | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||