Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SIL1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Ataxia, Ms. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | SIL1 |
| Full Name | SIL1 Nucleotide Exchange Factor |
| Chromosome | 5q31.2 |
| Protein Type | Chaperone |
| Function | By stimulating ATP hydrolysis and substrate release from BiP, SIL1 facilitates the protein folding cycle in the ER lumen. |
| Molecular Weight | 52 kDa |
| UniProt ID | Q9H3K5 |
| NCBI Gene ID | 22954 |
| Ensembl ID | ENSG00000135902 |
| OMIM | 608005 |
| GeneCards | SIL1 |
| Human Protein Atlas | SIL1 |
| Approach | Status |
| ER stress modulators | Research |
| Gene therapy | Preclinical |
| Associated Diseases | Ataxia, Ms |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SIL1["<b>SIL1</b>"]
Ms{"Ms"}
SIL1 -->|"associated with"| Ms
Ataxia{"Ataxia"}
SIL1 -->|"associated with"| Ataxia
STUB1["STUB1"]
SIL1 -->|"associated with"| STUB1
FMR1["FMR1"]
SIL1 -->|"associated with"| FMR1
TWNK["TWNK"]
SIL1 -->|"associated with"| TWNK
PNPLA6["PNPLA6"]
SIL1 -->|"associated with"| PNPLA6
neurodegeneration["neurodegeneration"]
SIL1 -->|"implicated in"| neurodegeneration
WFS1["WFS1"]
WFS1 -->|"associated with"| SIL1
HARS["HARS"]
HARS -->|"associated with"| SIL1
ATM["ATM"]
ATM -->|"associated with"| SIL1
CLPP["CLPP"]
CLPP -->|"associated with"| SIL1
SETX["SETX"]
SETX -->|"associated with"| SIL1
LARS2["LARS2"]
LARS2 -->|"associated with"| SIL1
POLG["POLG"]
POLG -->|"associated with"| SIL1
style SIL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| STUB1 | associated_with | gene | 0.60 |
| FMR1 | associated_with | gene | 0.60 |
| TWNK | associated_with | gene | 0.60 |
| PNPLA6 | associated_with | gene | 0.60 |
| HARS | associated_with | gene | 0.60 |
| WFS1 | associated_with | gene | 0.60 |
| SETX | associated_with | gene | 0.60 |
| RNF216 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||