gene

SIL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections
0Hypotheses
0Analyses
10Outgoing
9Incoming

Summary

SIL1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Ataxia, Ms. Connected to 14 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolSIL1
Full NameSIL1 Nucleotide Exchange Factor
Chromosome5q31.2
Protein TypeChaperone
FunctionBy stimulating ATP hydrolysis and substrate release from BiP, SIL1 facilitates the protein folding cycle in the ER lumen.
Molecular Weight52 kDa
UniProt IDQ9H3K5
NCBI Gene ID22954
Ensembl IDENSG00000135902
OMIM608005
GeneCardsSIL1
Human Protein AtlasSIL1
ApproachStatus
ER stress modulatorsResearch
Gene therapyPreclinical
Associated DiseasesAtaxia, Ms
KG Connections19 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SIL1 — AlphaFold Q9H3K5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

SIL1 Gene

gene · 747 words

HARS1 — Histidyl-tRNA Synthetase 1

gene · 1686 words

Presubiculum

cell · 801 words

TWNK Gene

gene · 759 words

SIL1 Protein

protein · 710 words

WFS1 — Wolfram Syndrome 1

gene · 679 words

Pathway Diagram

graph TD
    SIL1["<b>SIL1</b>"]
    Ms{"Ms"}
    SIL1 -->|"associated with"| Ms
    Ataxia{"Ataxia"}
    SIL1 -->|"associated with"| Ataxia
    STUB1["STUB1"]
    SIL1 -->|"associated with"| STUB1
    FMR1["FMR1"]
    SIL1 -->|"associated with"| FMR1
    TWNK["TWNK"]
    SIL1 -->|"associated with"| TWNK
    PNPLA6["PNPLA6"]
    SIL1 -->|"associated with"| PNPLA6
    neurodegeneration["neurodegeneration"]
    SIL1 -->|"implicated in"| neurodegeneration
    WFS1["WFS1"]
    WFS1 -->|"associated with"| SIL1
    HARS["HARS"]
    HARS -->|"associated with"| SIL1
    ATM["ATM"]
    ATM -->|"associated with"| SIL1
    CLPP["CLPP"]
    CLPP -->|"associated with"| SIL1
    SETX["SETX"]
    SETX -->|"associated with"| SIL1
    LARS2["LARS2"]
    LARS2 -->|"associated with"| SIL1
    POLG["POLG"]
    POLG -->|"associated with"| SIL1
    style SIL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

TargetRelationTypeStr
Msassociated_withdisease0.65
Ataxiaassociated_withdisease0.65
STUB1associated_withgene0.60
FMR1associated_withgene0.60
TWNKassociated_withgene0.60

Incoming (9)

SourceRelationTypeStr
WFS1associated_withgene0.60
HARSassociated_withgene0.60
ATMassociated_withgene0.60
CLPPassociated_withgene0.60
SETXassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found