gene

ICAM5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ICAM5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

15Outgoing

13Incoming

Summary

Page for ICAM5 (Intercellular Adhesion Molecule 5)

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🧬 Gene Info

Gene Symbol	ICAM5
Full Name	Intercellular Adhesion Molecule 5
Chromosome	19p13.2
Function	ICAM5 (Intercellular Adhesion Molecule 5), also known as Telencephalin, is a neuron-specific cell adhesion molecule belonging to the immunoglobulin superfamily.
UniProt ID	[Q9UMF0](https://www.uniprot.org/uniprot/Q9UMF0)
Ensembl ID	ENSG00000196376
GeneCards	ICAM5
Human Protein Atlas	ICAM5
Associated Diseases	neurodegeneration
KG Connections	28 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ICAM5["<b>ICAM5</b>"]
    Cancer{"Cancer"}
    ICAM5 -->|"expressed_in"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    ICAM5 -->|"expressed_in"| Neurodegeneration
    JAG1(["JAG1"])
    ICAM5 -->|"expressed_in"| JAG1
    PENK(["PENK"])
    ICAM5 -->|"expressed_in"| PENK
    T_Cell["T Cell"]
    ICAM5 -->|"expressed_in"| T_Cell
    Neuron["Neuron"]
    ICAM5 -->|"expressed_in"| Neuron
    ICAM1(["ICAM1"])
    ICAM1 -->|"expressed_in"| ICAM5
    TNF(["TNF"])
    TNF -->|"expressed_in"| ICAM5
    TDP_43(["TDP-43"])
    TDP_43 -->|"expressed_in"| ICAM5
    SYP(["SYP"])
    SYP -->|"expressed_in"| ICAM5
    style ICAM5 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (15)

Target	Relation	Type	Str
Cancer	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
JAG1	expressed_in	gene	0.60
PENK	expressed_in	gene	0.60
SYP	expressed_in	gene	0.60
JAG1	associated_with	gene	0.60
PENK	associated_with	gene	0.60
TNF	associated_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
T Cell	expressed_in	cell_type	0.60
Neuron	expressed_in	cell_type	0.60
AND	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
Tdp-43	expressed_in	pathway	0.60
Proteins	associated_with	protein	0.50

Incoming (13)

Source	Relation	Type	Str
ICAM1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
TDP-43	expressed_in	gene	0.60
SYP	expressed_in	gene	0.60
JAG1	expressed_in	gene	0.60
PENK	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
ICAM1	associated_with	gene	0.50
PENK	associated_with	gene	0.50
JAG1	associated_with	gene	0.50
Neurodegeneration	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found