gene

JAG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

202Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Comprehensive coverage of JAG1 in Notch signaling, neurodevelopment, Alzheimer's disease, and Notch ligand biology in neurodegeneration

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🧬 Gene Info

Gene Symbol	JAG1
Full Name	Jagged 1 (Notch Ligand)
Chromosome	20p12.2
Function	is a critical member of the Notch ligand family that plays essential roles in cell fate determination, embryonic development, tissue homeostasis, and increasingly recognized functions in neurodegen...
Primary Expression	Cerebral cortex, Cochlea, Liver, Heart
Molecular Weight	~134 kDa
Amino Acids	218 aa
Pathways	Notch, NOTCH, Notch signaling
UniProt ID	P78504
NCBI Gene ID	1950
Ensembl ID	ENSG00000101384
OMIM	184756
GeneCards	JAG1
Human Protein Atlas	JAG1
Protein Length	1,218 amino acids
Associated Diseases	ALS, neurodegeneration
Interactions	NOTCH1, ULK1, Rb, NOTCH, RNA, APOPTOSIS
KG Connections	202 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: JAG1 — AlphaFold P78504 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    JAG1["JAG1"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    JAG1["JAG1"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    JAG1["JAG1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    JAG1["JAG1"] -->|"therapeutic target"| Cancer["Cancer"]
    JAG1["JAG1"] -->|"therapeutic target"| Als["Als"]
    JAG1["JAG1"] -->|"therapeutic target"| Inflammation["Inflammation"]
    JAG1["JAG1"] -->|"therapeutic target"| Ms["Ms"]
    JAG1["JAG1"] -->|"therapeutic target"| Cardiac["Cardiac"]
    JAG1["JAG1"] -->|"therapeutic target"| MITF["MITF"]
    JAG1["JAG1"] -->|"therapeutic target"| GAIN["GAIN"]
    JAG1["JAG1"] -->|"therapeutic target"| AXIN2["AXIN2"]
    JAG1["JAG1"] -->|"therapeutic target"| CD44["CD44"]
    style JAG1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiac fill:#ef5350,stroke:#333,color:#e0e0e0
    style MITF fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GAIN fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style AXIN2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CD44 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (126)

Target	Relation	Type	Str
Apoptosis	mediates	process	0.90
Autophagy	associated_with	process	0.90
Carcinoma	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Prostate Cancer	therapeutic_target	disease	0.75
Notch signaling	participates_in	pathway	0.70
CANCER	therapeutic_target	gene	0.70
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Tumor	interacts_with	disease	0.65
Als	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
ALS	activates	disease	0.65
MITF	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
AXIN2	therapeutic_target	gene	0.60
CD44	therapeutic_target	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
ATF3	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
DKK1	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60

Incoming (76)

Source	Relation	Type	Str
HSV-1	upregulates	disease	0.92
FGF20	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
AXIN2	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
DKK1	therapeutic_target	gene	0.60
ULK1	inhibits	gene	0.60
ICAM1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
TDP-43	expressed_in	gene	0.60
SYP	expressed_in	gene	0.60
ICAM5	expressed_in	gene	0.60
NOTCH1	inhibits	gene	0.60
PENK	expressed_in	gene	0.60
ICAM5	associated_with	gene	0.60
ABCB1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
ATF3	targets	gene	0.60
AXIN2	targets	gene	0.60
CD44	targets	gene	0.60
CLDN1	targets	gene	0.60
DKK1	targets	gene	0.60
FGF18	targets	gene	0.60
FGF20	targets	gene	0.60
FZD7	targets	gene	0.60
IL10	targets	gene	0.60
CDH1	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

JAG1

Understanding Entity Pages

Summary

Wiki Pages (21)

JAG1 — Jagged 1

Notch Signaling Pathway in Neurodegeneration

Meningeal Lymphatics

NICASTRIN Gene

Intercellular Adhesion Molecule-5 Protein

LEF1

HES1 Gene

NOTCH2 — Notch Receptor 2

PENK Gene

Notch Signaling Modulation Therapy for Neurodegeneration

Notch Signaling in 4R-Tauopathies

RBPJ Gene

NOTCH3 Protein

DLL4 Gene

HEY1 — Hairy/Enhancer-of-Split Related with YRPW Motif 1

NOTCH3 — Notch Receptor 3

mfng

DLL3 — Delta-Like 3

JAG2 Gene