Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about il17a: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | IL17A |
| Full Name | Interleukin 17A |
| Chromosome | 6p12.2. |
| Function | is a 155-amino acid secreted glycoprotein that forms disulfide-linked homodimers. |
| Primary Expression | non-immune cells including neurons and glia |
| Amino Acids | 155 aa |
| Pathways | NF-κB pathway, MAPK pathway, TGF-β |
| UniProt ID | [Q16552](https://www.uniprot.org/uniprot/Q16552) |
| Ensembl ID | ENSG00000112116 |
| OMIM | 603250 |
| GeneCards | IL17A |
| Human Protein Atlas | IL17A |
| Associated Diseases | Neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
IL17A["IL17A"]
IL17A -->|"inhibits"| PARKIN["PARKIN"]
IL17A -->|"promotes"| mitochondrial_dysfunction["mitochondrial dysfunction"]
IL17A -->|"involved_in"| Staphylococcus_Aureus_Infectio["Staphylococcus Aureus Infection"]
IL17A -->|"inhibits"| BMAL1["BMAL1"]
IL17A -->|"activates"| DNMT1["DNMT1"]
IL17A -->|"implicated in"| neurodegeneration["neurodegeneration"]
hyperforin["hyperforin"] -->|"inhibits"| IL17A| Target | Relation | Type | Str |
|---|---|---|---|
| PARKIN | inhibits | gene | 0.90 |
| myeloid cell immune response | mediates | process | 0.90 |
| mitochondrial dysfunction | promotes | phenotype | 0.90 |
| Staphylococcus Aureus Infection | involved_in | disease | 0.85 |
| Staphylococcus Aureus Infection | mediates | disease | 0.85 |
| BMAL1 | inhibits | protein | 0.70 |
| DNMT1 | activates | protein | 0.70 |
| Senescence | associated_with | disease | 0.65 |
| CFH | associated_with | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| IL3 | associated_with | gene | 0.60 |
| IL9 | associated_with | gene | 0.60 |
| Epigenetic | associated_with | pathway | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| hyperforin | inhibits | drug | 0.80 |
| IL10 | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||