Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CFH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CFH is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, implicated in. Associated with Aging, Als, Alzheimer. Connected to 45 entities in the SciDEX knowledge graph.
| Gene Symbol | CFH |
| Chromosome | 1q31.3 |
| Function | Factor H functions as the main soluble regulator of the alternative complement pathway |
| Amino Acids | 121 aa |
| Pathways | Complement, Autophagy, Akt, Phagocytosis, Mitochondrial Function |
| Ensembl ID | ENSG00000005381 |
| GeneCards | CFH |
| Human Protein Atlas | CFH |
| N-terminal domains (1-4) | Mediate decay-accelerating and cofactor activity |
| Central domains (5-7) | Bind C3b and C3d |
| C-terminal domains (18-20) | Mediate host surface recognition and attachment |
| Associated Diseases | Als, Alzheimer, Atherosclerosis, Heart Failure, Neurodegeneration, Senescence |
| Interactions | AKT2, TFE3, SIRT5, TFEB, TIMP1, TNF |
| KG Connections | 74 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CFH["<b>CFH</b>"]
Neurodegeneration{"Neurodegeneration"}
CFH -->|"associated with"| Neurodegeneration
Alzheimer{"Alzheimer"}
CFH -->|"associated with"| Alzheimer
Aging{"Aging"}
CFH -->|"activates"| Aging
Complement(["Complement"])
CFH -->|"associated with"| Complement
C1S["C1S"]
CFH -->|"associated with"| C1S
RS6664877["RS6664877"]
CFH -->|"associated with"| RS6664877
GENES["GENES"]
CFH -->|"associated with"| GENES
CR1["CR1"]
CFH -->|"associated with"| CR1
AKT2["AKT2"]
CFH -->|"activates"| AKT2
COMPLEMENT["COMPLEMENT"]
CFH -->|"activates"| COMPLEMENT
TFE3["TFE3"]
CFH -->|"activates"| TFE3
AUTOPHAGY["AUTOPHAGY"]
CFH -->|"activates"| AUTOPHAGY
CLU["CLU"]
CLU -->|"associated with"| CFH
C1S -->|"associated with"| CFH
CLUSTERIN["CLUSTERIN"]
CLUSTERIN -->|"associated with"| CFH
C1Q["C1Q"]
C1Q -->|"associated with"| CFH
CR1 -->|"associated with"| CFH
RS6656401["RS6656401"]
RS6656401 -->|"associated with"| CFH
RS3919533["RS3919533"]
RS3919533 -->|"associated with"| CFH
AGING["AGING"]
AGING -->|"activates"| CFH
PHAGOCYTOSIS["PHAGOCYTOSIS"]
PHAGOCYTOSIS -->|"activates"| CFH
style CFH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Heart Failure | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Atherosclerosis | associated_with | disease | 0.65 |
| Senescence | associated_with | disease | 0.65 |
| C1S | associated_with | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| AKT2 | activates | gene | 0.60 |
| TFE3 | activates | gene | 0.60 |
| SIRT5 | activates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| CLU | implicated_in | gene | 0.60 |
| CLUSTERIN | implicated_in | gene | 0.60 |
| C1Q | associated_with | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| CR1 | interacts_with | gene | 0.60 |
| complement cascade | participates_in | pathway | 0.60 |
| Complement | associated_with | pathway | 0.60 |
| RS6664877 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| COMPLEMENT | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Akt | activates | pathway | 0.60 |
| Phagocytosis | activates | pathway | 0.60 |
| Mitochondrial Function | activates | pathway | 0.60 |
| Complement | activates | pathway | 0.60 |
| COMPLEMENT | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| RS6664877 | implicated_in | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| Amyloid | associated_with | pathway | 0.60 |
| Epigenetic | associated_with | pathway | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| TIMP1 | activates | gene | 0.55 |
| TNF | activates | gene | 0.55 |
| circadian regulation | participates_in | pathway | 0.55 |
| LIMK1 | activates | gene | 0.55 |
| ROCK1 | activates | gene | 0.55 |
| oxidative stress response | participates_in | pathway | 0.55 |
| RNA | activates | gene | 0.55 |
| unfolded protein response | participates_in | pathway | 0.55 |
| astrocytes | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CLU | associated_with | gene | 0.60 |
| C1S | associated_with | gene | 0.60 |
| CLUSTERIN | associated_with | gene | 0.60 |
| C1Q | associated_with | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| IL10 | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| IL17A | associated_with | gene | 0.60 |
| C1S | interacts_with | gene | 0.60 |
| AKT2 | activates | gene | 0.60 |
| RS6656401 | associated_with | gene | 0.60 |
| RS3919533 | associated_with | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| PHAGOCYTOSIS | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| RS6656401 | implicated_in | gene | 0.60 |
| RS3919533 | implicated_in | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| RS6664877 | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| BMAL1 | activates | gene | 0.55 |
| C3 | activates | gene | 0.55 |
| CD55 | activates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||