gene

CFH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CFH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections
0Hypotheses
0Analyses
46Outgoing
28Incoming

Summary

CFH is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, implicated in. Associated with Aging, Als, Alzheimer. Connected to 45 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolCFH
Chromosome1q31.3
FunctionFactor H functions as the main soluble regulator of the alternative complement pathway
Amino Acids121 aa
PathwaysComplement, Autophagy, Akt, Phagocytosis, Mitochondrial Function
Ensembl IDENSG00000005381
GeneCardsCFH
Human Protein AtlasCFH
N-terminal domains (1-4)Mediate decay-accelerating and cofactor activity
Central domains (5-7)Bind C3b and C3d
C-terminal domains (18-20)Mediate host surface recognition and attachment
Associated DiseasesAls, Alzheimer, Atherosclerosis, Heart Failure, Neurodegeneration, Senescence
InteractionsAKT2, TFE3, SIRT5, TFEB, TIMP1, TNF
KG Connections74 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

CFH

gene · 882 words

Epigenetic Mechanisms in Alzheimer's Disease

mechanism · 3425 words

Complement Activation in Corticobasal Degeneration

mechanism · 3025 words

Non-coding RNAs in Neurodegeneration

mechanism · 2937 words

Retinal Rod Photoreceptors Neurodegeneration

cell_type · 2604 words

C2 (Complement Component 2)

gene · 1670 words

Pathway Diagram

graph TD
    CFH["<b>CFH</b>"]
    Neurodegeneration{"Neurodegeneration"}
    CFH -->|"associated with"| Neurodegeneration
    Alzheimer{"Alzheimer"}
    CFH -->|"associated with"| Alzheimer
    Aging{"Aging"}
    CFH -->|"activates"| Aging
    Complement(["Complement"])
    CFH -->|"associated with"| Complement
    C1S["C1S"]
    CFH -->|"associated with"| C1S
    RS6664877["RS6664877"]
    CFH -->|"associated with"| RS6664877
    GENES["GENES"]
    CFH -->|"associated with"| GENES
    CR1["CR1"]
    CFH -->|"associated with"| CR1
    AKT2["AKT2"]
    CFH -->|"activates"| AKT2
    COMPLEMENT["COMPLEMENT"]
    CFH -->|"activates"| COMPLEMENT
    TFE3["TFE3"]
    CFH -->|"activates"| TFE3
    AUTOPHAGY["AUTOPHAGY"]
    CFH -->|"activates"| AUTOPHAGY
    CLU["CLU"]
    CLU -->|"associated with"| CFH
    C1S -->|"associated with"| CFH
    CLUSTERIN["CLUSTERIN"]
    CLUSTERIN -->|"associated with"| CFH
    C1Q["C1Q"]
    C1Q -->|"associated with"| CFH
    CR1 -->|"associated with"| CFH
    RS6656401["RS6656401"]
    RS6656401 -->|"associated with"| CFH
    RS3919533["RS3919533"]
    RS3919533 -->|"associated with"| CFH
    AGING["AGING"]
    AGING -->|"activates"| CFH
    PHAGOCYTOSIS["PHAGOCYTOSIS"]
    PHAGOCYTOSIS -->|"activates"| CFH
    style CFH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

TargetRelationTypeStr
Neurodegenerationassociated_withdisease0.65
Alzheimerassociated_withdisease0.65
Agingactivatesdisease0.65
Heart Failureassociated_withdisease0.65
Alsassociated_withdisease0.65

Incoming (28)

SourceRelationTypeStr
CLUassociated_withgene0.60
C1Sassociated_withgene0.60
CLUSTERINassociated_withgene0.60
C1Qassociated_withgene0.60
CR1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found