Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about INTERLEUKIN-18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | INTERLEUKIN |
| GeneCards | INTERLEUKIN |
| Human Protein Atlas | INTERLEUKIN |
| Associated Diseases | Fibrosis, Als, Cancer, Multiple Sclerosis, Neuroinflammation, Neurodegeneration |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
INTERLEUKIN_18(["INTERLEUKIN-18"])
INFLAMMASOME("INFLAMMASOME")
CYTOKINES("CYTOKINES")
Pyroptosis["Pyroptosis"]
GENE_EXPRESSION("GENE EXPRESSION")
Insulin_Resistance["Insulin Resistance"]
ANGPT1("ANGPT1")
Differentiation("Differentiation")
INSULIN("INSULIN")
LDLR(["LDLR"])
INTERLEUKIN_18 -->|"activates"| INFLAMMASOME
INTERLEUKIN_18 -->|"activates"| CYTOKINES
INTERLEUKIN_18 -->|"activates"| Pyroptosis
INTERLEUKIN_18 -->|"expressed in"| GENE_EXPRESSION
INTERLEUKIN_18 -->|"activates"| Insulin_Resistance
INTERLEUKIN_18 -->|"activates"| ANGPT1
INTERLEUKIN_18 -->|"activates"| Differentiation
INTERLEUKIN_18 -->|"activates"| INSULIN
LDLR -->|"expressed in"| INTERLEUKIN_18
style INTERLEUKIN_18 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| CYTOKINES | activates | concept | 0.50 |
| Pyroptosis | activates | pathway | 0.50 |
| GENE EXPRESSION | expressed_in | concept | 0.50 |
| Insulin Resistance | activates | disease | 0.50 |
| ANGPT1 | activates | concept | 0.50 |
| INSULIN | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LDLR | expressed_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||