protein

CASPASE-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

0Hypotheses

0Analyses

50Outgoing

47Incoming

Summary

Caspase-1 is an inflammatory caspase that executes pyroptosis and processes pro-inflammatory cytokines. It plays critical roles in neuroinflammation and is implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions.

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🔬 Protein Info

Gene Symbol	CASPASE
GeneCards	CASPASE
Human Protein Atlas	CASPASE
Associated Diseases	ferroptosis
Interactions	BCL-XL, HO-1, Proteins, ALZHEIMER, GASDERMIN, NLRP3
KG Connections	99 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CASPASE_1["<b>CASPASE-1</b>"]
    A1_Inductor_Secretion["A1 Inductor Secretion"]
    CASPASE_1 -->|"catalyzes"| A1_Inductor_Secretion
    A1_Inductor_Secretion["A1 Inductor Secretion"]
    CASPASE_1 -->|"mediates"| A1_Inductor_Secretion
    NLRP3["NLRP3"]
    NLRP3 -->|"activates"| CASPASE_1
    IL_18["IL-18"]
    CASPASE_1 -->|"co discussed"| IL_18
    IL_1_["IL-1Beta"]
    CASPASE_1 -->|"co discussed"| IL_1_
    NLRP3["NLRP3"]
    CASPASE_1 -->|"co discussed"| NLRP3
    WAS["WAS"]
    CASPASE_1 -->|"co discussed"| WAS
    ISCHEMIA["ISCHEMIA"]
    CASPASE_1 -->|"activates"| ISCHEMIA
    INFLAMMASOME["INFLAMMASOME"]
    CASPASE_1 -->|"activates"| INFLAMMASOME
    Astrocytes["Astrocytes"]
    CASPASE_1 -->|"activates"| Astrocytes
    BCL_XL["BCL-XL"]
    CASPASE_1 -->|"inhibits"| BCL_XL
    apoptosis["apoptosis"]
    CASPASE_1 -->|"inhibits"| apoptosis
    Pyroptosis["Pyroptosis"]
    CASPASE_1 -->|"inhibits"| Pyroptosis
    Necroptosis["Necroptosis"]
    CASPASE_1 -->|"inhibits"| Necroptosis
    Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    CASPASE_1 -->|"activates"| Nlrp3_Inflammasome
    HO_1["HO-1"]
    CASPASE_1 -->|"activates"| HO_1
    TNF__["TNF-alpha"]
    CASPASE_1 -->|"activates"| TNF__
    NF__B["NF-kappaB"]
    CASPASE_1 -->|"activates"| NF__B
    Astrocyte["Astrocyte"]
    CASPASE_1 -->|"activates"| Astrocyte
    Neuroinflammatory["Neuroinflammatory"]
    CASPASE_1 -->|"activates"| Neuroinflammatory
    NF__B["NF-kappaB"]
    CASPASE_1 -->|"inhibits"| NF__B
    TNF__["TNF-alpha"]
    CASPASE_1 -->|"inhibits"| TNF__
    Proteins["Proteins"]
    CASPASE_1 -->|"inhibits"| Proteins
    INFLAMMASOME["INFLAMMASOME"]
    CASPASE_1 -->|"associated with"| INFLAMMASOME
    INFLAMMASOME["INFLAMMASOME"]
    CASPASE_1 -->|"expressed in"| INFLAMMASOME
    Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    CASPASE_1 -->|"expressed in"| Nlrp3_Inflammasome
    Proteins["Proteins"]
    CASPASE_1 -->|"expressed in"| Proteins
    inflammation["inflammation"]
    CASPASE_1 -->|"activates"| inflammation
    ALZHEIMER["ALZHEIMER"]
    CASPASE_1 -->|"activates"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    CASPASE_1 -->|"activates"| Alzheimer_S_Disease

Outgoing (60)

Target	Relation	Type	Str
IL-18	co_discussed	protein	0.50
IL-1Β	co_discussed	protein	0.50
NLRP3	co_discussed	protein	0.50
WAS	co_discussed	protein	0.50
ISCHEMIA	activates	disease	0.50
Astrocytes	activates	cell_type	0.50
BCL-XL	inhibits	protein	0.50
apoptosis	inhibits	process	0.50
Pyroptosis	inhibits	pathway	0.50
Necroptosis	inhibits	pathway	0.50
Nlrp3 Inflammasome	activates	pathway	0.50
HO-1	activates	protein	0.50
TNF-α	activates	concept	0.50
NF-κB	activates	concept	0.50
Astrocyte	activates	cell_type	0.50
Neuroinflammatory	activates	pathway	0.50
NF-κB	inhibits	concept	0.50
TNF-α	inhibits	concept	0.50
Proteins	inhibits	protein	0.50
Nlrp3 Inflammasome	expressed_in	pathway	0.50
Proteins	expressed_in	protein	0.50
inflammation	activates	pathway	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
CYTOKINES	activates	concept	0.50
Pyroptosis	activates	pathway	0.50
PROINFLAMMATORY CYTOKINES	activates	concept	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
GASDERMIN	activates	gene	0.50
apoptosis	interacts_with	process	0.50
Substantia Nigra	interacts_with	entity	0.50
CELL DEATH	activates	concept	0.50
inflammation	interacts_with	pathway	0.50
ALZHEIMER	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
Infection	interacts_with	disease	0.50
Proteins	interacts_with	protein	0.50
inflammation	associated_with	pathway	0.50
MAPK	associated_with	gene	0.50
NF-κB	associated_with	concept	0.50
CYTOKINES	associated_with	concept	0.50
Proteins	associated_with	protein	0.50
CYTOKINES	regulates	concept	0.50
Cortex	regulates	brain_region	0.50
Nlrp3 Inflammasome	regulates	pathway	0.50
IL-1	regulates	concept	0.50
ferroptosis	associated_with	phenotype	0.50

Incoming (51)

Source	Relation	Type	Str
NLRP3	activates	protein	0.80
C1Q	co_discussed	gene	0.50
ALZHEIMER	activates	gene	0.50
AMYLOID	activates	gene	0.50
WAS	causes	protein	0.50
microglia	activates	cell_type	0.50
IL-1Β	activates	protein	0.50
IL-18	activates	protein	0.50
MLKL	inhibits	gene	0.50
GSDMD	inhibits	protein	0.50
TREM2	activates	gene	0.50
GSDMD	activates	protein	0.50
KEAP1	activates	gene	0.50
NRF2	activates	gene	0.50
NQO1	activates	gene	0.50
IL-6	activates	protein	0.50
NQO1 PROTEIN	activates	protein	0.50
DEPRESSION	activates	disease	0.50
IL-6	inhibits	protein	0.50
IL-1Β	inhibits	protein	0.50
Neurodegeneration	inhibits	disease	0.50
NLRP3	inhibits	protein	0.50
NAIP	associated_with	gene	0.50
NLRC4	associated_with	gene	0.50
CARD8	associated_with	gene	0.50
GSDMD	associated_with	protein	0.50
NLRP1	associated_with	protein	0.50
NLRP3	associated_with	protein	0.50
microglia	expressed_in	cell_type	0.50
NLRP3	expressed_in	protein	0.50
GASDERMIN D	activates	protein	0.50
STROKE	interacts_with	gene	0.50
PYCARD	interacts_with	gene	0.50
NLRP3	interacts_with	protein	0.50
DRD2	activates	gene	0.50
IL-10	associated_with	protein	0.50
IL-6	associated_with	protein	0.50
IL-1Β	associated_with	protein	0.50
TLR4	activates	gene	0.50
GFAP	regulates	gene	0.50
IL-18	regulates	protein	0.50
NLRP3	regulates	protein	0.50
BDNF	associated_with	gene	0.50
GPX4	associated_with	gene	0.50
GFAP	associated_with	gene	0.50
CREB	associated_with	protein	0.50
GASDERMIN D	associated_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CASPASE-1

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Novel Therapy Index

calcium-dysregulation-comparison

neuroinflammation

nlrc5-protein

Glia-Neuron Crosstalk in Alzheimer's Disease

Neuroinflammation-Mitochondria Crosstalk Pathway

GBA1→GCase→Lysosome→PD Causal Chain

Frontotemporal Dementia

Pannexin 1 and P2X7 Receptor Signaling in Neurodegeneration

er-stress-neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

autophagy-lysosomal-alzheimers

Ferroptosis in Neurodegeneration

Advanced Glycation End Products in Neurodegeneration

Neuroinflammation in Amyotrophic Lateral Sclerosis

Neuroinflammation in Parkinson's Disease

Cytochrome c Protein