concept

JAK/STAT PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK/STAT PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

1Hypotheses

2Analyses

24Outgoing

8Incoming

0Experiments

4Debates

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💡 Concept Info

Name	JAK/STAT PATHWAY
Key Genes/Proteins	IL6, JAK2, STAT3, TNF
Related Diseases	APOPTOSIS, INFLAMMATION, MULTIPLE SCLEROSIS, NEURODEGENERATION, NEUROINFLAMMATION

Pathway Diagram

graph TD
    JAK_STAT_PATHWAY[JAK/STAT PATHWAY]
    JAK_STAT_PATHWAY -->|regulates| Gene_Expression[Gene Expression]
    JAK_STAT_PATHWAY -->|involved_in| Hematologic_Malignancies[Hematologic Malignancies]
    JAK_STAT_PATHWAY -.protects against.-> NEUROINFLAMMATION[NEUROINFLAMMATION]
    JAK_STAT_PATHWAY -->|activates| MICROGLIA[MICROGLIA]
    JAK_STAT_PATHWAY -.protects against.-> DOPAMINERGIC_NEURONS[DOPAMINERGIC NEURONS]
    JAK_STAT_PATHWAY -->|causes| APOPTOSIS[APOPTOSIS]
    RLN[RLN] -->|activates| JAK_STAT_PATHWAY

Outgoing (24)

Target	Relation	Type	Str
Gene Expression	regulates	process	0.95
Hematologic Malignancies	involved_in	disease	0.90
hidradenitis suppurativa	associated_with	disease	0.75
Motor neuron apoptosis	causes	phenotype	0.70
astrocyte modulation	therapeutic_target_for	mechanism	0.70
NEUROINFLAMMATION	protects_against	phenotype	0.65
NEUROINFLAMMATION	activates	phenotype	0.65
MICROGLIA	activates	cell_type	0.65
DOPAMINERGIC NEURONS	protects_against	cell_type	0.65
MICROGLIA	inhibits	cell_type	0.65
APOPTOSIS	causes	phenotype	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
NEURONS	associated_with	cell_type	0.45
APOPTOSIS	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
MACROPHAGES	associated_with	cell_type	0.45
MACROPHAGE	associated_with	cell_type	0.45
INFLAMMATION	associated_with	phenotype	0.45
STAT3	associated_with	gene	0.45
TNF	associated_with	gene	0.45
IL6	associated_with	gene	0.45
JAK2	associated_with	gene	0.45
VEGFA	associated_with	gene	0.45
TP53	associated_with	gene	0.45

Incoming (8)

Source	Relation	Type	Str
RLN	activates	protein	0.85
IL-6	activates	protein	0.70
41918508	involved in	paper	0.60
NEUROINFLAMMATION	associated_with	phenotype	0.45
PARKINSON'S DISEASE	associated_with	disease	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45
DOPAMINERGIC NEURONS	associated_with	cell_type	0.45
NEURODEGENERATION	associated_with	disease	0.45