gene

KCNQ3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNQ3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections
0Hypotheses
0Analyses
13Outgoing
8Incoming

Summary

KCNQ3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Als, Cancer, Ms. Connected to 20 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolKCNQ3
Full NamePotassium Voltage-Gated Channel Subfamily Q Member 3
Chromosome8q24.22
Protein TypeChannel
FunctionM-channels are slowly activating and deactivating potassium channels that regulate neuronal excitability by controlling the resting membrane potential [@jentsch2000].
Primary ExpressionBrain, Substantia Nigra, Cortex, Hippocampus
Molecular Weight95.5 kDa
UniProt IDO43525
NCBI Gene ID3786
Ensembl IDENSG00000184160
OMIM121201
GeneCardsKCNQ3
Human Protein AtlasKCNQ3
InteractionsEGFR, ERK, RUNX1, ANXIETY, CANCER
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: KCNQ3 — AlphaFold O43525 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

KCNQ3 Gene

gene · 1086 words

Kv7.3 Potassium Channel

protein · 3781 words

Kv7.2 Potassium Channel

protein · 3469 words

KCNQ2 Encephalopathy

disease · 3173 words

Voltage-Gated Potassium (Kv) Channel Neurons

cell · 1885 words

MECP2 — Methyl-CpG Binding Protein 2

gene · 1655 words

Pathway Diagram

graph TD
    KCNQ3["<b>KCNQ3</b>"]
    Als{"Als"}
    KCNQ3 -->|"regulates"| Als
    Tumor{"Tumor"}
    KCNQ3 -->|"activates"| Tumor
    Ms{"Ms"}
    KCNQ3 -->|"regulates"| Ms
    Cancer{"Cancer"}
    KCNQ3 -->|"activates"| Cancer
    EGFR["EGFR"]
    KCNQ3 -->|"activates"| EGFR
    KCNQ2["KCNQ2"]
    KCNQ3 -->|"regulates"| KCNQ2
    MECP2["MECP2"]
    KCNQ3 -->|"regulates"| MECP2
    ERK["ERK"]
    KCNQ3 -->|"activates"| ERK
    GENES["GENES"]
    KCNQ3 -->|"regulates"| GENES
    RUNX1["RUNX1"]
    KCNQ3 -->|"activates"| RUNX1
    HDAC2["HDAC2"]
    KCNQ3 -->|"regulates"| HDAC2
    AND["AND"]
    KCNQ3 -->|"activates"| AND
    ERK -->|"activates"| KCNQ3
    HDAC2 -->|"regulates"| KCNQ3
    EGFR -->|"activates"| KCNQ3
    MECP2 -->|"regulates"| KCNQ3
    CANCER["CANCER"]
    CANCER -->|"activates"| KCNQ3
    KCNQ2 -->|"regulates"| KCNQ3
    GENES -->|"regulates"| KCNQ3
    RUNX1 -->|"activates"| KCNQ3
    style KCNQ3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

TargetRelationTypeStr
Alsregulatesdisease0.65
Tumoractivatesdisease0.65
Msregulatesdisease0.65
Canceractivatesdisease0.65
EGFRactivatesgene0.60

Incoming (8)

SourceRelationTypeStr
HDAC2regulatesgene0.60
EGFRactivatesgene0.60
MECP2regulatesgene0.60
KCNQ2regulatesgene0.60
ERKactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found