Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNQ3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KCNQ3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Als, Cancer, Ms. Connected to 20 entities in the SciDEX knowledge graph.
| Gene Symbol | KCNQ3 |
| Full Name | Potassium Voltage-Gated Channel Subfamily Q Member 3 |
| Chromosome | 8q24.22 |
| Protein Type | Channel |
| Function | M-channels are slowly activating and deactivating potassium channels that regulate neuronal excitability by controlling the resting membrane potential [@jentsch2000]. |
| Primary Expression | Brain, Substantia Nigra, Cortex, Hippocampus |
| Molecular Weight | 95.5 kDa |
| UniProt ID | O43525 |
| NCBI Gene ID | 3786 |
| Ensembl ID | ENSG00000184160 |
| OMIM | 121201 |
| GeneCards | KCNQ3 |
| Human Protein Atlas | KCNQ3 |
| Interactions | EGFR, ERK, RUNX1, ANXIETY, CANCER |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNQ3["<b>KCNQ3</b>"]
Als{"Als"}
KCNQ3 -->|"regulates"| Als
Tumor{"Tumor"}
KCNQ3 -->|"activates"| Tumor
Ms{"Ms"}
KCNQ3 -->|"regulates"| Ms
Cancer{"Cancer"}
KCNQ3 -->|"activates"| Cancer
EGFR["EGFR"]
KCNQ3 -->|"activates"| EGFR
KCNQ2["KCNQ2"]
KCNQ3 -->|"regulates"| KCNQ2
MECP2["MECP2"]
KCNQ3 -->|"regulates"| MECP2
ERK["ERK"]
KCNQ3 -->|"activates"| ERK
GENES["GENES"]
KCNQ3 -->|"regulates"| GENES
RUNX1["RUNX1"]
KCNQ3 -->|"activates"| RUNX1
HDAC2["HDAC2"]
KCNQ3 -->|"regulates"| HDAC2
AND["AND"]
KCNQ3 -->|"activates"| AND
ERK -->|"activates"| KCNQ3
HDAC2 -->|"regulates"| KCNQ3
EGFR -->|"activates"| KCNQ3
MECP2 -->|"regulates"| KCNQ3
CANCER["CANCER"]
CANCER -->|"activates"| KCNQ3
KCNQ2 -->|"regulates"| KCNQ3
GENES -->|"regulates"| KCNQ3
RUNX1 -->|"activates"| KCNQ3
style KCNQ3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | regulates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| EGFR | activates | gene | 0.60 |
| KCNQ2 | regulates | gene | 0.60 |
| MECP2 | regulates | gene | 0.60 |
| HDAC2 | regulates | gene | 0.60 |
| ERK | activates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| RUNX1 | activates | gene | 0.60 |
| ANXIETY | activates | gene | 0.60 |
| Neuron | activates | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||