protein

MECP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MECP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

240Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Methyl-CpG Binding Protein 2 (MECP2) is a transcriptional regulator critical for neuronal development and function. MECP2 mutations cause Rett syndrome and are implicated in MECP2 duplication syndrome and other neuropsychiatric disorders.

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🔬 Protein Info

Gene Symbol	MECP2
Full Name	Methyl-CpG Binding Protein 2
Protein Family	Methyl-CpG binding domain (MBD) family
Function	In neurons, MeCP2 binds broadly across the genome, preferentially at methylated CpG dinucleotides and non-CpG methylation sites (particularly mCA), which are highly abundant in mature neurons [@birdse
Primary Expression	Cerebral cortex, Hippocampus, Cerebellum, Brainstem, Basal ganglia, Thalamus
Subcellular Localization	Nucleus (chromatin-associated)
Molecular Weight	53 kDa
Amino Acids	80 aa
Pathways	Akt, Epigenetic, Mapk, Mitophagy
UniProt ID	P51608
Ensembl ID	ENSG00000169057
GeneCards	MECP2
Human Protein Atlas	MECP2
Symbol [@preclinical2024] MECP2 [@vashi2019] [@lyst2013] [@chahrour2008] Full Name [@ramocki2010] Methyl-CpG Binding Protein 2 [@ncbi] [@omim] [@allen] Chromosome [@allena] Xq28 [@allenb] [@brainspan] [@genes] NCBI Gene [@proteins] 4204 [@bdnf] [@httpswwwncbinlmnihgovgene] [@httpsensemblorghomosapiensgenesummarygensg] Ensembl [@httpsomimorgentry] ENSG00000169057 [@httpswwwuniprotorguniprotp] [@mecp] [@mecpa] OMIM	300005
Associated Diseases	Als, Autism, Epilepsy, Rett syndrome
Interactions	SIRT1, JUN, TRKB, BDNF, NRF2, CASP3
KG Connections	239 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MECP2 — AlphaFold P51608 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MECP2["MECP2"] -->|"regulates"| MMP9["MMP9"]
    MECP2["MECP2"] -->|"interacts"| SIRT1["SIRT1"]
    MECP2["MECP2"] -->|"causes"| Rett_syndrome["Rett syndrome"]
    MECP2["MECP2"] -->|"regulates"| BDNF["BDNF"]
    MECP2["MECP2"] -.->|"inhibits"| Ms["Ms"]
    MECP2["MECP2"] -.->|"inhibits"| Depression["Depression"]
    FUS["FUS"] -->|"regulates"| MECP2["MECP2"]
    NRBP1["NRBP1"] -.->|"inhibits"| MECP2["MECP2"]
    BDNF_1["BDNF"] -->|"activates"| MECP2["MECP2"]
    CSF1R["CSF1R"] -.->|"inhibits"| MECP2["MECP2"]
    style MECP2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (157)

Target	Relation	Type	Str
APOPTOSIS	represses	process	0.80
SYP	co_expressed_with	protein	0.75
MMP9	regulates	protein	0.70
SIRT1	interacts_with	protein	0.70
Rett syndrome	causes	disease	0.70
BDNF	regulates	protein	0.70
Ms	inhibits	disease	0.65
Depression	inhibits	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Depression	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Aging	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Ischemia	activates	disease	0.65
Stroke	regulates	disease	0.65
ALS	activates	disease	0.65
Als	expressed_in	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Epilepsy	causes	disease	0.65
Als	inhibits	disease	0.65
Epilepsy	encodes	disease	0.65
Autism	associated_with	disease	0.65
HDAC2	regulates	gene	0.60
KCNQ3	regulates	gene	0.60
KCNQ2	regulates	gene	0.60
JUN	activates	gene	0.60
TRKB	activates	gene	0.60
BDNF	activates	gene	0.60
NRF2	activates	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
SYNCRIP	therapeutic_target	gene	0.60
G3BP1	therapeutic_target	gene	0.60
CASP3	activates	gene	0.60
RPS6KB1	regulates	gene	0.60
HDAC1	regulates	gene	0.60
JUN	regulates	gene	0.60
PLA2G6	associated_with	entity	0.60
NT3	activates	gene	0.60
NEPRILYSIN	activates	gene	0.60
SIRT1	activates	gene	0.60
APP	activates	gene	0.60

Incoming (83)

Source	Relation	Type	Str
FUS	regulates	protein	0.80
NRBP1	inhibits	gene	0.60
BDNF	activates	gene	0.60
CSF1R	inhibits	gene	0.60
KCNQ3	regulates	gene	0.60
EGFR	regulates	gene	0.60
KCNQ2	regulates	gene	0.60
HDAC2	regulates	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
EWSR1	therapeutic_target	gene	0.60
YBX1	therapeutic_target	gene	0.60
BNIP3L	expressed_in	gene	0.60
IL6	regulates	gene	0.60
FAS	activates	gene	0.60
MAPK1	regulates	gene	0.60
IL1B	regulates	gene	0.60
MYC	regulates	gene	0.60
AKT	regulates	gene	0.60
HDAC3	regulates	entity	0.60
NT4	activates	gene	0.60
PLA2G6	inhibits	gene	0.60
HTT	activates	gene	0.60
HUNTINGTIN	regulates	gene	0.60
CALCINEURIN	activates	gene	0.60
CREB1	expressed_in	gene	0.60
MEF2C	expressed_in	gene	0.60
GAIN	regulates	gene	0.60
HUNTINGTIN	phosphorylates	gene	0.60
NGF	associated_with	gene	0.60
POLE	causes	gene	0.60
POLE	encodes	gene	0.60
POLE	therapeutic_target	gene	0.60
ACSL4	associated_with	gene	0.60
GRIN1	associated_with	gene	0.60
HCN1	associated_with	gene	0.60
KMT2D	associated_with	gene	0.60
DNMT3A	regulates	gene	0.60
ERK	regulates	gene	0.60
ERK	activates	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
NATURAL COMPOUNDS	therapeutic_target	gene	0.60
MITOPHAGY	regulates	gene	0.60
NEURON	inhibits	gene	0.60
ERK	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
ASTROCYTE	inhibits	gene	0.60
CREB	activates	gene	0.60
GENES	regulates	gene	0.60
CANCER	regulates	gene	0.60
RUNX1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.469

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MECP2

Understanding Entity Pages

Summary

Wiki Pages (21)

MECP2 — Methyl-CpG Binding Protein 2

GRIA3 Gene

Epigenetic Dysregulation in Neurodegeneration

PTBP2 - Polypyrimidine Tract Binding Protein 2

aav-gene-therapy-neurodegeneration

LIN7B — Lin-7 Homolog B

MYT1L Gene

X-Linked Intellectual Disability

H3F3B Gene — H3.3 Histone B

PDLIM7 Epigenetic Activation in Parkinson's Disease

Sex-Specific Mechanisms in Alzheimer's Disease

Epigenetics in Amyotrophic Lateral Sclerosis

Howard Hughes Medical Institute

Epigenetics in Parkinson's Disease

CRISPRi Epigenetic Silencing of SNCA for Parkinson's Disease

GABRE Gene

crispr-gene-editing

TET1 Gene

GRID2 — Glutamate Ionotropic Receptor Delta Type Subunit 2

Brain-Derived Neurotrophic Factor in Neurodegeneration