Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BCL2L13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BCL2L13 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 323 entities in the SciDEX knowledge graph.
| Gene Symbol | BCL2L13 |
| Full Name | BCL2 Like 13 |
| Chromosome | 22q11.21 |
| Protein Type | Mitochondrial Outer Membrane Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 32 kDa |
| Pathways | Apoptosis, Er Stress, Immune Response, MAPK signaling, Mitochondrial Function |
| UniProt ID | [Q9HAW5](https://www.uniprot.org/uniprot/Q9HAW5) |
| GeneCards | BCL2L13 |
| Human Protein Atlas | BCL2L13 |
| Associated Diseases | AD, ALI, ALS, Aging, Alzheimer |
| Interactions | NLRP3, ABCD3, FIP200, RTN3, SESN2, SNCAIP |
| KG Connections | 723 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BCL2L13["BCL2L13"] -->|"Interacts With"| Dementia["Dementia"]
BCL2L13["BCL2L13"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
BCL2L13["BCL2L13"] -->|"Interacts With"| Als["Als"]
BCL2L13["BCL2L13"] -->|"Interacts With"| Alzheimer["Alzheimer"]
BCL2L13["BCL2L13"] -->|"Interacts With"| Parkinson["Parkinson"]
BCL2L13["BCL2L13"] -->|"Interacts With"| Ms["Ms"]
BCL2L13["BCL2L13"] -->|"Associated With"| Ischemia["Ischemia"]
BCL2L13["BCL2L13"] -->|"Inhibits"| Aging["Aging"]
CAT["CAT"] -->|"Interacts With"| BCL2L13["BCL2L13"]
OPTN["OPTN"] -->|"Interacts With"| BCL2L13["BCL2L13"]
DNM1L["DNM1L"] -->|"Interacts With"| BCL2L13["BCL2L13"]
CANX["CANX"] -->|"Interacts With"| BCL2L13["BCL2L13"]
LGALS3["LGALS3"] -->|"Interacts With"| BCL2L13["BCL2L13"]
style BCL2L13 fill:#8d4900,color:#e0e0e0
style Dementia fill:#b71c1c,color:#e0e0e0
style Cardiovascular fill:#b71c1c,color:#e0e0e0
style Als fill:#b71c1c,color:#e0e0e0
style Alzheimer fill:#b71c1c,color:#e0e0e0
style Parkinson fill:#b71c1c,color:#e0e0e0
style Ms fill:#b71c1c,color:#e0e0e0
style Ischemia fill:#b71c1c,color:#e0e0e0
style Aging fill:#b71c1c,color:#e0e0e0
style CAT fill:#8d4900,color:#e0e0e0
style OPTN fill:#8d4900,color:#e0e0e0
style DNM1L fill:#8d4900,color:#e0e0e0
style CANX fill:#8d4900,color:#e0e0e0
style LGALS3 fill:#8d4900,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| autophagy pathway | participates_in | pathway | 0.70 |
| ubiquitin-proteasome | participates_in | pathway | 0.70 |
| apoptosis pathway | participates_in | pathway | 0.70 |
| Dementia | interacts_with | disease | 0.65 |
| Cardiovascular | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Ischemia | associated_with | disease | 0.65 |
| Aging | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Cardiovascular | inhibits | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | interacts_with | disease | 0.65 |
| Cardiovascular | therapeutic_target | disease | 0.65 |
| Frontotemporal Dementia | interacts_with | disease | 0.65 |
| Ftd | interacts_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Lymphoma | inhibits | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Glioblastoma | therapeutic_target | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Glioblastoma | inhibits | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Ischemia | regulates | disease | 0.65 |
| Stroke | expressed_in | disease | 0.65 |
| Ischemia | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Carcinoma | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | biomarker_for | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Aging | degrades | disease | 0.65 |
| Cardiovascular | degrades | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| NLRP3 | interacts_with | gene | 0.60 |
| ABCD3 | interacts_with | gene | 0.60 |
| FIP200 | interacts_with | gene | 0.60 |
| RTN3 | interacts_with | gene | 0.60 |
| SESN2 | interacts_with | gene | 0.60 |
| TOMM20 | associated_with | gene | 0.60 |
| ATG7 | associated_with | gene | 0.60 |
| GAPDH | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CAT | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| LGALS3 | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| PEX3 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| BCL2 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| SNCAIP | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| FAM134B | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| EPAS1 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| BCL2L11 | interacts_with | gene | 0.60 |
| MUL1 | interacts_with | gene | 0.60 |
| BNIP3 | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
| EIF2S1 | interacts_with | gene | 0.60 |
| RIPK3 | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| CHOP | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| NBR1 | interacts_with | gene | 0.60 |
| EMD | interacts_with | gene | 0.60 |
| MAPK8 | interacts_with | gene | 0.60 |
| RHOT1 | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| HIF1A | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| GBA | interacts_with | gene | 0.60 |
| FUNDC1 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||