gene

BCL2L13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL2L13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

723Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

BCL2L13 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 323 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolBCL2L13
Full NameBCL2 Like 13
Chromosome22q11.21
Protein TypeMitochondrial Outer Membrane Protein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight32 kDa
PathwaysApoptosis, Er Stress, Immune Response, MAPK signaling, Mitochondrial Function
UniProt ID[Q9HAW5](https://www.uniprot.org/uniprot/Q9HAW5)
GeneCardsBCL2L13
Human Protein AtlasBCL2L13
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
InteractionsNLRP3, ABCD3, FIP200, RTN3, SESN2, SNCAIP
KG Connections723 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

BCL2L13

gene · 640 words

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

clinical · 4511 words

GBA Gene Mutations and Parkinson's Disease Risk

mechanism · 3113 words

TUFM Gene

gene · 2437 words

LAMA2 — Laminin Subunit Alpha 2

gene · 1707 words

COX4I1

gene · 1587 words

Pathway Diagram

graph TD
    BCL2L13["BCL2L13"] -->|"Interacts With"| Dementia["Dementia"]
    BCL2L13["BCL2L13"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    BCL2L13["BCL2L13"] -->|"Interacts With"| Als["Als"]
    BCL2L13["BCL2L13"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    BCL2L13["BCL2L13"] -->|"Interacts With"| Parkinson["Parkinson"]
    BCL2L13["BCL2L13"] -->|"Interacts With"| Ms["Ms"]
    BCL2L13["BCL2L13"] -->|"Associated With"| Ischemia["Ischemia"]
    BCL2L13["BCL2L13"] -->|"Inhibits"| Aging["Aging"]
    CAT["CAT"] -->|"Interacts With"| BCL2L13["BCL2L13"]
    OPTN["OPTN"] -->|"Interacts With"| BCL2L13["BCL2L13"]
    DNM1L["DNM1L"] -->|"Interacts With"| BCL2L13["BCL2L13"]
    CANX["CANX"] -->|"Interacts With"| BCL2L13["BCL2L13"]
    LGALS3["LGALS3"] -->|"Interacts With"| BCL2L13["BCL2L13"]
    style BCL2L13 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Ischemia fill:#b71c1c,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (499)

TargetRelationTypeStr
autophagy pathwayparticipates_inpathway0.70
ubiquitin-proteasomeparticipates_inpathway0.70
apoptosis pathwayparticipates_inpathway0.70
Dementiainteracts_withdisease0.65
Cardiovascularinteracts_withdisease0.65

Incoming (224)

SourceRelationTypeStr
CATinteracts_withgene0.60
OPTNinteracts_withgene0.60
DNM1Linteracts_withgene0.60
CANXinteracts_withgene0.60
LGALS3interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found