Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MBNL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | MBNL1 |
| Function | MBNL1 is a zinc finger RNA-binding protein that regulates alternative splicing, RNA localization, and RNA stability through binding to specific sequence motifs[@charizanis2012]: |
| Primary Expression | White Matter |
| Pathways | insulin signaling |
| Ensembl ID | ENSG00000138700 |
| GeneCards | MBNL1 |
| Human Protein Atlas | MBNL1 |
| Associated Diseases | Huntington's disease |
| Interactions | MBNL2, DMPK, RNA, AND, Proteins |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MBNL1["MBNL1"]
MBNL1 -->|"interacts"| MBNL2["MBNL2"]
MBNL1 -->|"interacts"| RNA["RNA"]
MBNL1 -->|"interacts"| DMPK["DMPK"]
MBNL1 -->|"inhibits"| AND["AND"]
MBNL1 -->|"expressed in"| White_Matter["White Matter"]
DMPK -->|"interacts"| MBNL1
BDNF["BDNF"] -->|"regulates"| MBNL1
MBNL2 -->|"interacts"| MBNL1
RNA -->|"interacts"| MBNL1| Target | Relation | Type | Str |
|---|---|---|---|
| BDNF | regulates_retrograde_signaling_of | gene | 0.80 |
| MBNL2 | interacts_with | gene | 0.60 |
| DMPK | interacts_with | gene | 0.60 |
| DMPK | inhibits | gene | 0.60 |
| MBNL2 | expressed_in | gene | 0.60 |
| RNA | interacts_with | gene | 0.60 |
| RNA | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| insulin signaling | participates_in | pathway | 0.55 |
| White Matter | expressed_in | brain_region | 0.55 |
| Huntington's disease | causes | disease | 0.55 |
| neurons | expressed_in | cell_type | 0.55 |
| RNA | biomarker_for | gene | 0.55 |
| Proteins | interacts_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CLCN1 | associated_with | gene | 0.60 |
| DMPK | interacts_with | gene | 0.60 |
| BDNF | regulates | gene | 0.60 |
| MBNL2 | interacts_with | gene | 0.60 |
| DMPK | expressed_in | gene | 0.60 |
| RNA | interacts_with | gene | 0.60 |
| CACNA1G | causes | gene | 0.55 |
| GRIN1 | causes | gene | 0.55 |
| HTT | causes | gene | 0.55 |
| CLCN1 | causes | gene | 0.55 |
| DMPK | causes | gene | 0.55 |
| INSR | causes | gene | 0.55 |
| BDNF | co_expressed_with | gene | 0.50 |
| DMPK | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||